Imperial College London
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ProfessorTimothyHallett

Faculty of Medicine, School of Public Health

Professor of Global Health
 
 
 
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Contact

 

+44 (0)20 7594 1150timothy.hallett

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schmit:2021:ije/dyaa253,
author = {Schmit, N and Nayagam, S and Thursz, M and Hallett, T},
doi = {ije/dyaa253},
journal = {International Journal of Epidemiology},
pages = {560--569},
title = {The global burden of chronic hepatitis B virus infection: comparison of country-level prevalence estimates from four research groups},
url = {http://dx.doi.org/10.1093/ije/dyaa253},
volume = {50},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Progress towards viral hepatitis elimination goals relies on accurate estimates of chronic hepatitis B virus  (HBV)  infection  prevalence.  We  compared  existing  sources  of  the  most  recent  country-level estimates  from  2013-2017  to  investigate  the  extent  and  underlying  drivers  of  differences  between them. Methods: The four commonly cited sources of global prevalence estimates, the Institute for Health Metrics and Evaluation, Schweitzer et al, World Health Organization (WHO) and CDA Foundation, were compared by  calculating  pairwise  differences  between  sets  of  estimates  and  assessing  their  within-country variation.  Differences  in  underlying  empirical  data  and  modelling  methods  were  investigated  as contributors to differences in sub-Saharan African estimates. Results: The  four  sets  of  estimates  across  all  ages  were  comparable  overall  and  agreed  on  the  global distribution of HBV burden. WHO and CDA produced the most similar estimates, differing by a median of 0.8 percentage points. Larger discrepancies were seen in estimates of prevalence in children under 5 years of age and in sub-Saharan African countries, where the median pairwise differences were 2.7 and  2.4  percentage  points  for  all  age  prevalence  and  in  children,  respectively.  Recency  and representativeness of included data, and different modelling assumptions of the age distribution of HBV burden, seemed to contribute to these differences. Conclusion: Current prevalence estimates, particularly those from WHO and CDA based on more recent empirical data,  provide  a  useful  resource  to  assess  the  population-level  burden  of  chronic  HBV  infection. However, further seroprevalence data in young children is needed particularly in sub-Saharan Africa. This  is  a  priority  as  monitoring  progress  towards  elimination  depends  on  improved  knowledge  of prevalence in this age group.
AU  - Schmit,N
AU  - Nayagam,S
AU  - Thursz,M
AU  - Hallett,T
DO  - ije/dyaa253
EP  - 569
PY  - 2021///
SN  - 0300-5771
SP  - 560
TI  - The global burden of chronic hepatitis B virus infection: comparison of country-level prevalence estimates from four research groups
T2  - International Journal of Epidemiology
UR  - http://dx.doi.org/10.1093/ije/dyaa253
UR  - https://academic.oup.com/ije/article/50/2/560/6053478
UR  - http://hdl.handle.net/10044/1/85081
VL  - 50
ER  -
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