Imperial College London
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ProfessorTimothyHallett

Faculty of Medicine, School of Public Health

Professor of Global Health
 
 
 
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Contact

 

+44 (0)20 7594 1150timothy.hallett

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Birger:2017:10.1371/journal.pone.0177195,
author = {Birger, RB and Thuy, L and Kouyos, RD and Grenfell, BT and Hallett, TB},
doi = {10.1371/journal.pone.0177195},
journal = {PLoS ONE},
title = {The impact of HCV therapy in a high HIV-HCV prevalence population: A modeling study on people who inject drugs in Ho Chi Minh City, Vietnam},
url = {http://dx.doi.org/10.1371/journal.pone.0177195},
volume = {12},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundHuman Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) coinfection is a majorglobal health problem especially among people who inject drugs (PWID), with significantclinical implications. Mathematical models have been used to great effect to shape HIVcare, but few have been proposed for HIV/HCV.MethodsWe constructed a deterministic compartmental ODE model that incorporated layers for HIVdisease progression, HCV disease progression and PWID demography. Antiretroviral therapy(ART) and Methadone Maintenance Therapy (MMT) scale-ups were modeled as from2016 and projected forward 10 years. HCV treatment roll-out was modeled beginning in2026, after a variety of MMT scale-up scenarios, and projected forward 10 years.ResultsOur results indicate that scale-up of ART has a major impact on HIV though not on HCV burden.MMT scale-up has an impact on incidence of both infections. HCV treatment roll-outhas a measurable impact on reductions of deaths, increasing multifold the mortality reductionsafforded by just ART/MMT scale-ups. ConclusionHCV treatment roll-out can have major and long-lasting effects on averting PWID deaths ontop of those averted by ART/MMT scale-up. Efficient intervention scale-up of HCV alongsideHIV interventions is critical in Vietnam.
AU  - Birger,RB
AU  - Thuy,L
AU  - Kouyos,RD
AU  - Grenfell,BT
AU  - Hallett,TB
DO  - 10.1371/journal.pone.0177195
PY  - 2017///
SN  - 1932-6203
TI  - The impact of HCV therapy in a high HIV-HCV prevalence population: A modeling study on people who inject drugs in Ho Chi Minh City, Vietnam
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0177195
UR  - http://hdl.handle.net/10044/1/56568
VL  - 12
ER  -
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