I am a Lecturer in Environmental Toxicology & Biomarkers in the Department of Metabolism, Digestion, and Reproduction. My main research interests are in the application of molecular profiling technologies – primarily metabolic profiling using NMR and MS based platforms – to study aspects of human health and disease. A key research question of importance is how to improve exposure assessment in individuals, small area studies and molecular epidemiology projects investigating environmental exposures. I am also interested in addressing the need for a more comprehensive understanding of the toxicological implications of emerging materials such as nanoparticles. At present, a number of large-scale projects focused on developing the concept of the exposome are underway, and present new opportunities for metabolic research to help understand links between environmental exposures and human health outcomes.
I studied for a PhD in biological chemistry at Imperial College London, which was awarded in 2007. My thesis, "Analytical and chemometric investigations of congeneric substituted aniline metabolism" focused on investigating the metabolic fate of a number of substituted anilines in vivo using NMR, MS and UPLC. These studies are part of ongoing efforts to develop predictive models of xenobiotic metabolism.
I studied as an undergraduate at Exeter University in the Department of Chemistry. I was awarded a first-class honours degree in Biological and Medicinal Chemistry upon graduating in 2002
et al., Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure-property relationships, Organic and Biomolecular Chemistry, ISSN:1477-0520
et al., 2019, DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia, Environment International, Vol:126, ISSN:0160-4120, Pages:24-36
et al., 2018, Determinants of the urinary and serum metabolome in children from six European populations, Bmc Medicine, Vol:16, ISSN:1741-7015
et al., 2018, Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma; univariate and functionally-informed multivariate analyses, International Journal of Cancer, Vol:143, ISSN:0020-7136, Pages:1335-1347
et al., 2018, Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts, Scientific Reports, Vol:8, ISSN:2045-2322