Imperial College London
Alternate

Dr Tony Goldstone

Faculty of Medicine, Department of Brain Sciences

Reader in PsychoNeuroEndocrinology
 
 
 
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Contact

 

+44 (0)20 7594 5989tony.goldstone Website

 
 
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Location

 

S25Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Glaysher:2021:10.1016/j.clnu.2020.10.026,
author = {Glaysher, M and Ward, J and Aldhwayan, M and Ruban, A and Prechtl, CG and Fisk, HL and Chhina, N and Al-Najim, W and Smith, C and Klimowska-Nassar, N and Johnson, N and Falaschetti, E and Goldstone, AP and Miras, AD and Byrne, JP and Calder, PC and Teare, J},
doi = {10.1016/j.clnu.2020.10.026},
journal = {Clinical Nutrition},
pages = {2343--2354},
title = {The effect of a duodenal-jejunal bypass liner on lipid profile and blood concentrations of long chain polyunsaturated fatty acids},
url = {http://dx.doi.org/10.1016/j.clnu.2020.10.026},
volume = {40},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & aimsDuodenal-jejunal bypass liners (DJBLs) prevent absorption in the proximal small intestine, the site of fatty acid absorption. We sought to investigate the effects of a DJBL on blood concentrations of essential fatty acids (EFAs) and bioactive polyunsaturated fatty acids (PUFAs).MethodsSub-study of a multicentre, randomised, controlled trial with two treatment groups. Patients aged 18–65 years with type-2 diabetes mellitus and body mass index 30–50 kg/m2 were randomised to receive a DJBL for 12 months or best medical therapy, diet and exercise. Whole plasma PUFA concentrations were determined at baseline, 10 days, 6 and 11.5 months; data were available for n = 70 patients per group.ResultsWeight loss was significantly greater in the DJBL group compared to controls after 11.5 months: total body weight loss 11.3 ± 5.3% versus 6.0 ± 5.7% (mean difference [95% CI] = 5.27% [3.75, 6.80], p < 0.001). Absolute concentrations of both EFAs, linoleic acid and α-linolenic acid, and their bioactive derivatives, arachidonic acid, eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, were significantly lower in the DJBL group than in the control group at 6 and 11.5 months follow-up. Total serum cholesterol, LDL-cholesterol and HDL-cholesterol were also significantly lower in the DJBL group.ConclusionOne year of DJBL therapy is associated with superior weight loss and greater reductions in total serum cholesterol and LDL-cholesterol, but also depletion of EFAs and their longer chain derivatives. DJBL therapy may need to be offset by maintaining an adequate dietary intake of PUFAs or by supplementation.
AU  - Glaysher,M
AU  - Ward,J
AU  - Aldhwayan,M
AU  - Ruban,A
AU  - Prechtl,CG
AU  - Fisk,HL
AU  - Chhina,N
AU  - Al-Najim,W
AU  - Smith,C
AU  - Klimowska-Nassar,N
AU  - Johnson,N
AU  - Falaschetti,E
AU  - Goldstone,AP
AU  - Miras,AD
AU  - Byrne,JP
AU  - Calder,PC
AU  - Teare,J
DO  - 10.1016/j.clnu.2020.10.026
EP  - 2354
PY  - 2021///
SN  - 0261-5614
SP  - 2343
TI  - The effect of a duodenal-jejunal bypass liner on lipid profile and blood concentrations of long chain polyunsaturated fatty acids
T2  - Clinical Nutrition
UR  - http://dx.doi.org/10.1016/j.clnu.2020.10.026
UR  - https://www.sciencedirect.com/science/article/pii/S0261561420305549?via%3Dihub
UR  - http://hdl.handle.net/10044/1/84861
VL  - 40
ER  -
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