Imperial College London
Alternate

Dr Tony Goldstone

Faculty of Medicine, Department of Brain Sciences

Reader in PsychoNeuroEndocrinology
 
 
 
//

Contact

 

+44 (0)20 7594 5989tony.goldstone Website

 
 
//

Location

 

S25Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Guerrero-Hreins:2021:10.1016/j.pnpbp.2021.110303,
author = {Guerrero-Hreins, E and Goldstone, AP and Brown, RM and Sumithran, P},
doi = {10.1016/j.pnpbp.2021.110303},
journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
title = {The therapeutic potential of GLP-1 analogues for stress-related eating and role of GLP-1 in stress, emotion and mood: a review},
url = {http://dx.doi.org/10.1016/j.pnpbp.2021.110303},
volume = {110},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Stress and low mood are powerful triggers for compulsive overeating, a maladaptive form of eating leading to negative physical and mental health consequences. Stress-vulnerable individuals, such as people with obesity, are particularly prone to overconsumption of high energy foods and may use it as a coping mechanism for general life stressors. Recent advances in the treatment of obesity and related co-morbidities have focused on the therapeutic potential of anorexigenic gut hormones, such as glucagon-like peptide 1 (GLP-1), which acts both peripherally and centrally to reduce energy intake. Besides its appetite suppressing effect, GLP-1 acts on areas of the brain involved in stress response and emotion regulation. However, the role of GLP-1 in emotion and stress regulation, and whether it is a viable treatment for stress-induced compulsive overeating, has yet to be established. A thorough review of the pre-clinical literature measuring markers of stress, anxiety and mood after GLP-1 exposure points to potential divergent effects based on temporality. Specifically, acute GLP-1 injection consistently stimulates the physiological stress response in rodents whereas long-term exposure indicates anxiolytic and anti-depressive benefits. However, the limited clinical evidence is not as clear cut. While prolonged GLP-1 analogue treatment in people with type 2 diabetes improved measures of mood and general psychological wellbeing, the mechanisms underlying this may be confounded by associated weight loss and improved blood glucose control. There is a paucity of longitudinal clinical literature on mechanistic pathways by which stress influences eating behavior and how centrally-acting gut hormones such as GLP-1, can modify these. (250).
AU  - Guerrero-Hreins,E
AU  - Goldstone,AP
AU  - Brown,RM
AU  - Sumithran,P
DO  - 10.1016/j.pnpbp.2021.110303
PY  - 2021///
SN  - 0278-5846
TI  - The therapeutic potential of GLP-1 analogues for stress-related eating and role of GLP-1 in stress, emotion and mood: a review
T2  - Progress in Neuro-Psychopharmacology and Biological Psychiatry
UR  - http://dx.doi.org/10.1016/j.pnpbp.2021.110303
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33741445
UR  - http://hdl.handle.net/10044/1/88570
VL  - 110
ER  -
Download