Imperial College London

Dr Tony Goldstone

Faculty of MedicineDepartment of Brain Sciences

Senior Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 5989tony.goldstone Website

 
 
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Location

 

E313Burlington DanesHammersmith Campus

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Summary

 

Grants

Selected Research Grants:

2006  Wellcome Trust Value in People Award: “Using functional neuroimaging to identify hormone and brain appetite pathways and their defects in obesity”, PI

2007  Hammersmith Hospitals Trustees’ Research Committee: “How does ghrelin increase appetite in the brain: a functional magnetic resonance imaging study?”, PI

2008  Hammersmith Hospitals Trustees’ Research Committee: “How does hunger alter brain activity at rest?”, PI

2010-2012  Pfizer: “Growth hormone and traumatic brain injury: a neuroimaging study”, Co-PI with Dr David Sharp, Consultant Neurologist, Imperial College London

2010  Imperial College Healthcare Charity: “How do changes in gut hormones after obesity surgery reduce appetite in the brain?”, PI

2010-2011  NIHR CLRN award: Research nurse for NIHR CRN Portfolio studies in obesity imaging in CPG6, Imperial College Healthcare NHS Trust, PI

2010-2014  Core MRC funding, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Co-Investigator, with PI Prof. Jimmy Bell

2011-2012  GW Pharma: “Pilot, dose-ranging study to assess the effect of cannabidiol (CBD) on liver fat levels in subjects with fatty liver disease”, PI

2013-2017  NIHR/MRC Efficacy and Mechanism Evaluation Programme: “A randomized controlled trial of a duodenal sleeve bypass device (Endobarrier) compared with standard medical therapy for the management of obese subjects with type II diabetes”, includes functional MRI scans for mechanistic studies, Co-Investigator with PI Dr Julian Teare

2014-2018  MRC Experimental Medicine Challenge Grant MR/M007022/1: “Do appetitive gut hormones attenuate core behavioural components of addiction as new targets to prevent relapse in nicotine and alcohol dependence?”, Co-PI

2015-2021  MRC: “The MRC Addiction Research Clinical (MARC) Training programme”, Co-Investigator with PI Prof. Anne Lingford-Hughes

Student grants (Principal Supervisor and Investigator)

2009-2013  Wellcome Trust Research Training Fellowship Samantha Scholtz: “Functional magnetic resonance imaging of appetite and eating behaviour in obesity surgery”

2009-2010  Imperial College Healthcare Charity Clinical Research Fellowship Navpreet Chhina: “How does obesity surgery reduce appetite in the brain: a functional magnetic resonance imaging study?

2010-2013  MRC Clinical Training Fellowship Alex Miras: “Altered reward responses to sweet taste: a potential mechanism for weight loss after obesity surgery”

2011-2012  Imperial College Healthcare Charity Research Fellowship Carmen Tenorio Jiménez: “What is the impact of early growth hormone deficiency on brain function after traumatic brain injury?”

2011-2012  Imperial College Healthcare Charity Research Fellowship: “How do obesity and variations in obesity-associated genes influence eating behaviour: structural and functional MRI brain studies?”

2013-2016  MRC Clinical Training Fellowship Claire Feeney: “Does the metabolic syndrome impair recovery from traumatic brain injury: a prospective neuroimaging and cognitive study?”, Co-PI with David Sharp

2013-2016  Wellcome Trust - GlaxoSmithKline Translational Medicine Training Fellowship, Imperial College London Navpreet Chhina: “Multi-modal phenotyping and network analysis of eating and addictive behaviours after bariatric interventions for obesity and diabetes mellitus”

2017   ASPIRE Young Investigator Research Awards in Endocrinology, Triona O’Shea: “Predicting pituitary dysfunction following traumatic brain injury: early clinical, radiological, immunological, genetic and proteomic markers”

Collaborators

Jeff Brunstrom, University of Bristol, Psychology of eating behaviour, 2016

Jens Holst, Copenhagen University, Neuroendocrinology of glucagon-like peptide-1 processing, 2016

Graham Finlayson, University of Leeds, Psychology of eating behaviour, 2013

Bruce Gaylinn, Michael Thorner, University of Virginia, Neuroendocrinology of ghrelin, 2008

Tony Holland, University of Cambridge, Prader-Willi syndrome, 2005

Prof. Daniel J. Driscoll, Division of Pediatric Genetics, University of Florida, 2003

Guest Lectures

The hedonic and hungry brain: hormonal and surgical modulation of human eating and addictive behaviours, National Institutes of Health, USA, Bethesda, MD, USA, 2017

The pleasure of eating: functional neuroimaging of human eating and addictive behaviours, Oxford University Society of Biomedical Sciences, Oxford, 2017

The hedonic and hungry brain: hormonal and surgical modulation of human eating and addictive behaviours, Dept. of Pharmacology, University of Michigan, Ann Arbor, USA, 2017

The hedonic and hungry brain: nutritional, hormonal, surgical and genetic modulation of human eating and addictive behaviours, Institute for Diabetes Research and Metabolic Diseases (IDM), Helmholtz Center Munich, University of Tübingen, Tübingen, germany, 2017

The hedonic and hungry brain: nutritional, hormonal, surgical and genetic modulation of human eating and addictive behaviours, Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA, 2016

The hedonic and hungry brain: nutritional, hormonal, surgical and genetic modulation of human eating and addictive behaviours, Dept. of Nutritional Sciences, Pennsylvania State University, USA, State College, PA, USA, 2016

The hedonic and hungry brain: nutritional, hormonal, surgical and genetic modulation of human eating and addictive behaviours, Department of Psychological Sciences, University of Liverpool, Liverpool, UK, 2016

Nutritional, hormonal and surgical modulation of human eating behaviour, Sir Peter Mansfield Magnetic Resonance Imaging Centre (SPMMRC), University of Nottingham, Nottingham, UK, 2015

The hedonic and hungry brain: nutritional, hormonal, surgical and genetic modulation of human food reward, A*STAR Singapore Institute for Clinical Sciences, Singapore, 2014

The hedonic and hungry brain: nutritional, hormonal, surgical and genetic modulation of human food reward, Weill Cornell Medical College in Qatar, Doha, Qatar, 2014

The hedonic and hungry brain: nutritional, hormonal, surgical and genetic modulation of human food reward, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University, 2013

The genetic and pathophysiological link to severe childhood obesity, Obesity 2013: the management of obesity and its complications, British Journal of Hospital Medicine, London, 2013

Over‐eating and Diabetes: Is “Mind over Matter” the Key to Turning Things Around?;Practical management of type 2 diabetes. Targeting the body while engaging the mind., Royal College of General Practitioners, London, 2013

The hypothalamus and beyond: explaining the PWS phenotype, 8th International PWS Conference, Cambridge, UK, 2013

Influences of nutritional state, gut hormones, obesity and bariatric surgery on food reward, Institute of Metabolic Science, University of Cambridge, Cambridge, UK, 2012

Appetite and weight gain, Associate Parliamentary Food and Health Forum Obesity Conference, Houses of Parliament, London, UK, 2012

Modulation of food reward by nutritional state, gut hormones and bariatric surgery, Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK, 2012

Drugs vs. Behavior: Best Practice for Treating Hyperphagia will Involve Drugs in addition to Control of the Food Environment and Behavioral Modification, 2nd International Conference on Hyperphagia, Pennington Biomedical Research Center,, Baton Rouge, LA, USA, 2012

Bariatric Surgery is an Appropriate Treatment Option for Patients with Genetic or Hypothalamic Obesity, 2nd International Conference on Hyperphagia, Pennington Biomedical Research Center, Baton Rouge, LA, USA, 2012

Insight from fMRI studies into appetite regulation, 15th Congress of the European Neuroendocrine Association, Vienna, Austria, 2012

Influences of nutritional state, gut hormones, obesity and bariatric surgery on food reward, 15th Congress of the European Neuroendocrine Association, Vienna, Austria, 2012

Effects of nutritional state, gut hormones and bariatric surgery on food reward: human functional MRI studies, 11th International Conference on the Applications of Magnetic Resonance in Food, Wageningen, The Netherlands, 2012

Nutritional, hormonal and surgical regulation of food reward: functional neuroimaging studies, Universitat Pompeu Fabra (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), Barcelona, Spain, 2012

Transition and young adults in Prader-Willi syndrome, Paediatric Endocrinology and Diabetes Day, Royal Society of Medicine, London, UK, 2012

Guts or Brain? – Where Hormones Regulate Appetite, Food, Glorious Food! British Neuroscience Association Christmas Symposium 2011, The Royal Society, London, UK, 2011

Hypopituitarism after Traumatic Brain Injury, Head Injury an Integrated Approach Course, Royal College of Surgeons, London, UK, 2011

Prader-Willi syndrome and other non-surgical reasons of hypothalamic obesity: natural course and possible interventions, Hypothalamic Obesity in Children Satellite Symposium, 18th European Congress on Obesity, Istanbul, Turkey, 2011

Nutritional, hormonal and psychological modulation of food reward: functional MRI studies, Dept. of Endocrinology, William Harvey Research Institute, Barts and the London Medical School, London, UK, 2011

Modulation of food reward by fasting, dietary restraint and ghrelin, Department of Psychology, Roehampton University, London, UK, 2010

Fasting and ghrelin modulate brain food reward systems, New York Obesity Research Center, St. Luke’s Hospital, Columbia University, New York, USA, 2010

Neuroanatomical and neurofunctional abnormalities in Prader-Willi syndrome, 1st Italian Workshop on Prader-Willi Syndrome, Rome, Italy, 2010

Functional magnetic resonance imaging of appetite, Institute of Psychological Sciences, University of Leeds, Leeds, UK, 2009

How hungry are you? Functional magnetic resonance imaging of appetite, Institute of Psychiatry, Maudsley Hospital, London, UK, 2009

Prader-Willi syndrome: hunger, hormones and the head, Inter-Institute Endocrine Grand Rounds, National Institutes of Health,, Bethesda, MD, USA, 2009

Functional neuroimaging of human appetite, The Rank Prize Funds, Mini-Symposium on Regulation of Appetite, Lake District, UK, 2009

Prader-Willi syndrome: hunger, hormones and the head, Dept. of Endocrinology and Diabetes, University of Liverpool, Liverpool, UK, 2009

Neurobiology of human eating behaviour, 31st Annual Conference Prader-Willi Syndrome Association (USA), Baltimore, USA, 2009

Prader-Willi syndrome, 1st International Hyperphagia Conference, Baltimore, USA, 2009

Genetic obesity syndromes: implications for paediatric diagnosis and treatment, Controversial Issues in Paediatric Endocrinology, Royal College of Obstetricians and Gynaecologists, London, UK, 2009

Prader-Willi syndrome: from genetics to complex phenotype, International Symposium on Respiratory Control, Saint Maxim, France, 2008

Functional neuroimaging of appetite in humans and man, “Magnetic Resonance and an Ageing Population”, 14th Annual Meeting, British Chapter of International Society for Magnetic Resonance in Medicine, Newcastle University, Newcastle, UK, 2008

How hungry are you? Imaging appetite using functional magnetic resonance imaging, Wolfson Centre for Translational Research, University of Surrey, Guilford, Surrey, UK, 2008

Neuroendocrine mechanisms in the PWS phenotype, 6th International Prader-Willi Syndrome Scientific Meeting, Cluj, Romania, 2007

Understanding hunger: hormones and the head in obesity and Prader-Willi syndrome, Gothenburg University,, Sweden, 2007

Prader-Willi syndrome and peripheral satiety signals, “The comprehensive care of patients with PWS - consensus, questions and future directions,” Second Expert PWS Meeting, Toulouse, France, 2006

How hungry are you? Imaging appetite pathways in the brain, “Endocrine Imaging”, Endocrinology & Diabetes Section, Royal Society of Medicine, London, UK, 2006

Gut hormones and hunger in Prader-Willi syndrome and obesity, Merck Research Laboratories,, Rahway, New Jersey, USA, 2005

Ghrelin, hormones and hunger in Prader-Willi syndrome and obesity, New York Obesity Research Center, St. Luke’s Hospital, Columbia University, New York, USA, 2005

The hypothalamus, hormones and hunger: alterations in human obesity and illness, “Hypothalamic Integration of Energy Metabolism”, 24th International Summer School of Brain Research, Amsterdam, The Netherlands, 2005

The Prader-Willi syndrome, Bernard Wolfe Health Neuroscience Symposium, Churchill College, Cambridge, UK, 2005

The biology of eating disorders, 27th Annual Conference Prader-Willi Syndrome Association (USA), Orlando, Florida, 2005

Ghrelin and other gastrointestinal hormones in Prader-Willi syndrome, 5th Prader-Willi Syndrome International Conference, Christchurch, New Zealand, 2004

Genetics and natural history of Prader-Willi syndrome, Advances in Paediatric and Adolescent Endocrinology, Serono Symposia International, Naples, Italy, 2004

How do hormones and the hypothalamus control appetite?, Institut de Biologie du Développement de Marseille, Unité NMDA, Campus de Luminy, Marseille, France, 2003

Hypothalamic neuropeptides in Prader-Willi syndrome, PWS Symposium, 6th European Congress of Endocrinology, Lyon, France, 2003

Investigating the hypothalamus: what comes next?, Supporting People with Prader-Willi Syndrome: Integrating Research and Practice, Joint PWS Association (UK) and Royal Society of Medicine Forum on Learning Disability Conference, London, 2002

Hypothalamic neuropeptides and regulation of fat mass in Prader-Willi syndrome, ‘Prader-Willi Syndrome as a Model for Obesity’ Symposium, Foundation Growth Puberty Adolescence, Zurich, Switzerland, 2002

Prader-Willi syndrome: from hypothalamus to adipocyte, McKnight Brain Institute, University of Florida, Gainesville, USA, 2001

Hypothalamic neuropeptide Y and agouti-related protein in human illness and obesity, Pfizer Inc., Grotton, Conneticut, USA, 2001

Research Staff

Herlinger,K

Ling,YY

Nestor,L

Pannekoek,N

Research Student Supervision

Abeer,R, Neurobiological and behavioural correlates of food intake in obesity

Ahmed,M, Phenotypic comparison of patients with Prader-Willi syndrome, SNORD116 microdeletions, CPE and PC1/3 mutations

Al-Lababidi,M, Does duodenal-jejunal endoluminal liner (Endobarrier) insertion improve eating behaviour and food reward responses in obese patients with diabetes?

Alberts,S, White matter tract changes in obesity and associated metabolic and psychological traits

Ali,S, Effect of nutritional state on core behavioural components of food addiction: functional MRI studies?

Anjari,M, Effect of obesity on resting state networks using functional MRI

Antoniazzi,S, Influence of obesity and gastric bypass surgery on brain structure using magnetic resonance imaging

Azor,A, Characterising brain abnormalities in the genetic neurodevelopmental disorder Prader-Will syndrome using structural MR neuroimaging techniques

Benoy,G, Clinical, hormonal and biochemical phenotyping of patients with homozygous and heterozygous null mutation of pro-hormone processing enzyme Carboxypeptidase E

Bhanot,K, Investigating the effects of blast traumatic brain injury on the hypothalamus in a porcine model

Bowie,R, Effect of nutritional state on monetary reward processing: a functional MRI study

Brian,E, Anticipation of monetary reward in obesity, relationship with eating and addictive behaviours, and changes after gastric bypass surgery: human functional MRI study

Castellino,N, White matter tract changes in obesity and associated metabolic and psychological traits

Chhina,N, Eating and addictive behaviours after bariatric interventions for obesity and diabetes mellitus

Choi,K, Functional MRI of eating behaviour after obesity surgery

Croese,C, How does fasting increases appetite in the brain: a functional magnetic resonance imaging study?

Deliran,S, How does ghrelin increase appetite in the brain: a functional magnetic resonance imaging study?

Dhillon,P, Growth hormone deficiency and pituitary dysfunction after traumatic brain injury

Dunscombe,O, Prevalence and associations of TSH deficiency in adults after traumatic brain injury using TSH index

Feeney,C, The endocrine and metabolic factors influencing neuroinflammation and recovery following traumatic brain injury

Hannan,R, Motor response inhibition in obesity, relationship with eating and addictive behaviours, and changes after gastric bypass surgery: human functional MRI study

Hennessey,E, Does nutritional state modify brain responses to unpleasant images: a human functional MRI study?

Jallal,O, Clinical audit of prevalence and correlates of Vitamin D deficiency in adults after traumatic brain injury

Jimenez Tenorio,C, Hypopituitarism after traumatic brain injury

Lementec,S, Effect of gastric bypass surgery on resting state connectivity of brain reward regions using functional MRI

Ling,YY, Do appetitive gut hormones attenuate eating and addictive behaviours as new targets for treatment of obesity and tobacco dependence?

Malik,A, Clinical audit of hypopituitarism after traumatic brain injury

Matheiu,R, Effect of gastric bypass surgery on resting brain activity measured using arterial spin labelling

Miras,A, Effects of obesity surgery on food preferences, taste and reward in animals and humans

Moni-Nwinia,W, Functional magnetic resonance imaging of appetite in obesity surgery

Muhammed,K, Functional magnetic resonance imaging of human appetite

Niemi,M, Audit of hypopituitarism after traumatic brain injury

Nikolova,V, Links between human brain opioid-dopaminergic systems and eating behaviour: functional MRI and 11C-carfentanil PET studies in healthy subjects

Onokwai,N, Investigating links between eating, addictive and emotional behaviours in obesity

Orban,C, Optimisation of functional neuroimaging and behavioural paradigms to study impulsivity in obesity research

Parastika,T, Do baseline and early improvements in eating and addictive behaviours after gastric bypass surgery for obesity predict longer-term success?

Prechtl,C, Modulation of food reward systems by fasting and ghrelin: human functional MRI studies

Roelofs,E, The influence of nutritional state on inhibitory motor control

Sadron,A, Investigating the effects of obesity, metabolic syndrome, insulin resistance and obesity-associated FTO gene variant on brain age

Schmidt,M, Obesity surgery and functional magnetic resonance imaging of appetite

Scholtz,S, Behavioural and neuroimaging studies of food reward after bariatric surgery for obesity

Starke,J, Modulation of resting state networks by fasting and ghrelin: an fMRI study

Stephens,C, How the verbal and written handover from paramedics and ambulance staff influences the management of patients in the emergency department

Watkinson,A, Metabolic, hormonal and genetic influences on anticipatory food reward: a human functional MRI study

White,N, Analysis of the effects of obesity on brain grey matter: a voxel-based morphometry study.

Wilson,J, Psychological and metabolic influences on anticipatory food reward: a human functional MRI cohort study

Wong,T, How do fasting and ghrelin increase appetite in the brain: a functional magnetic resonance imaging study?

Yiorkas,A, Effect of obesity-associated gene variants on psychological traits and eating behaviour

Zaki,B, Are reductions in reward responses to high-energy food after gastric bypass surgery related to aversive symptoms and dumping syndrome?

Zaw-Linn,J, Clinical audit of the predictors for a false positive diagnosis of GH deficiency using the glucagon test in patients after traumatic brain injury