Imperial College London

ProfessorUtaGriesenbach

Faculty of MedicineNational Heart & Lung Institute

Professor of Molecular Medicine
 
 
 
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Contact

 

+44 (0)20 7594 7927u.griesenbach

 
 
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Assistant

 

Miss Samia Soussi +44 (0)20 7594 7980

 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

189 results found

Alton EWFW, Beekman JM, Boyd AC, Brand J, Carlon MS, Connolly MM, Chan M, Conlon S, Davidson HE, Davies JC, Davies LA, Dekkers JF, Doherty A, Gea-Sorli S, Gill DR, Griesenbach U, Hasegawa M, Higgins TE, Hironaka T, Hyndman L, McLachlan G, Inoue M, Hyde SC, Innes JA, Maher TM, Moran C, Meng C, Paul-Smith MC, Pringle IA, Pytel KM, Rodriguez-Martinez A, Schmidt AC, Stevenson BJ, Sumner-Jones SG, Toshner R, Tsugumine S, Wasowicz MW, Zhu Jet al., 2017, Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis, THORAX, Vol: 72, Pages: 137-147, ISSN: 0040-6376

JOURNAL ARTICLE

Ng-Blichfeldt J-P, Alcada J, Montero MA, Dean CH, Griesenbach U, Griffiths MJ, Hind Met al., 2017, Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema, THORAX, Vol: 72, Pages: 510-521, ISSN: 0040-6376

JOURNAL ARTICLE

Alton EWFW, Boyd AC, Davies JC, Gill DR, Griesenbach U, Harrison PT, Henig N, Higgins T, Hyde SC, Innes JA, Korman MSDet al., 2016, Genetic medicines for CF: Hype versus reality, PEDIATRIC PULMONOLOGY, Vol: 51, Pages: S5-S17, ISSN: 8755-6863

JOURNAL ARTICLE

Griesenbach U, Alton EWFW, Beekman JM, Boyd CA, Davies JC, Davies LA, Dekkers JF, Gill DR, Hasegawa M, Higgins TE, Hironaka T, Inoue M, Hyde SC, Innes AJ, Pringle IA, Pytel KM, Sumner-Jones SG, Tsugumine S, Wasowicz MWet al., 2016, Preparation for a First-in-Man Lentivirus Trial in Cystic Fibrosis Patients, 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: NATURE PUBLISHING GROUP, Pages: S214-S214, ISSN: 1525-0016

CONFERENCE PAPER

Griesenbach U, Davies JC, Alton E, 2016, Cystic fibrosis gene therapy: a mutation-independent treatment, CURRENT OPINION IN PULMONARY MEDICINE, Vol: 22, Pages: 602-609, ISSN: 1070-5287

JOURNAL ARTICLE

Paul-Smith MC, Bell RV, Alton WE, Alton EWFW, Griesenbach Uet al., 2016, Gene therapy for cystic fibrosis: recent progress and current aims, EXPERT OPINION ON ORPHAN DRUGS, Vol: 4, Pages: 649-658, ISSN: 2167-8707

JOURNAL ARTICLE

Pytel KM, Chan M, Meng C, Martinez AR, Boyd CA, Davies JC, Gill DR, Hyde SC, Innes AJ, Alton EWFW, Griesenbach Uet al., 2016, Pre-existing immunity to human parainfluenza virus (hPIV) does not affect rSIV.F/HN-mediated transduction efficiency., Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT, INC, Pages: A19-A19, ISSN: 1043-0342

CONFERENCE PAPER

Alton E, Armstrong D, Bayfield K, Bilton D, Boyd A, Cheng S, Cunningham S, Davies J, Elgmati H, Gill D, Greening A, Griesenbach U, Harman K, Higgins T, Hyde S, Innes J, McGovern M, Murray G, Porteous D, Saunders C, Scheule R, Simmonds N, Soussi S, Sumner-Jones S, Waller Met al., 2015, A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF REPEATED NEBULISATION OF NON-VIRAL CFTR GENE THERAPY IN PATIENTS WITH CYSTIC FIBROSIS, PEDIATRIC PULMONOLOGY, Vol: 50, Pages: 262-262, ISSN: 8755-6863

JOURNAL ARTICLE

Alton EWFW, Armstrong DK, Ashby D, Bayfield KJ, Bilton D, Bloomfield EV, Boyd AC, Brand J, Buchan R, Calcedo R, Carvelli P, Chan M, Cheng SH, Collie DDS, Cunningham S, Davidson HE, Davies G, Davies JC, Davies LA, Dewar MH, Doherty A, Donovan J, Dwyer NS, Elgmati HI, Featherstone RF, Gavino J, Gea-Sorli S, Geddes DM, Gibson JSR, Gill DR, Greening AP, Griesenbach U, Hansell DM, Harman K, Higgins TE, Hodges SL, Hyde SC, Hyndman L, Innes JA, Jacob J, Jones N, Keogh BF, Limberis MP, Lloyd-Evans P, Maclean AW, Manvell MC, McCormick D, McGovern M, McLachlan G, Meng C, Montero MA, Milligan H, Moyce LJ, Murray GD, Nicholson AG, Osadolor T, Parra-Leiton J, Porteous DJ, Pringle IA, Punch EK, Pytel KM, Quittner AL, Rivellini G, Saunders CJ, Scheule RK, Sheard S, Simmonds NJ, Smith K, Smith SN, Soussi N, Soussi S, Spearing EJ, Stevenson BJ, Sumner-Jones SG, Turkkila M, Ureta RP, Waller MD, Wasowicz MY, Wilson JM, Wolstenholme-Hogg Pet al., 2015, Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial, LANCET RESPIRATORY MEDICINE, Vol: 3, Pages: 684-691, ISSN: 2213-2600

JOURNAL ARTICLE

Alton EWFW, Boyd AC, Porteous DJ, Davies G, Davies JC, Griesenbach U, Higgins TE, Gill DR, Hyde SC, Innes JAet al., 2015, A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trail, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 192, Pages: 1389-1392, ISSN: 1073-449X

JOURNAL ARTICLE

Griesenbach U, 2015, A Phase IIb double-blind, placebo-controlled trial of non-viral mediated gene therapy for cystic fibrosis, Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT, INC, Pages: A5-A6, ISSN: 1043-0342

CONFERENCE PAPER

Griesenbach U, Alton E, Beekman J, Boyd A, Chan M, Davies JC, Davies L, Davidson H, Dekkers F, Gea-Sorli S, Gill D, Hasegawa M, Higgins T, Hyndman L, McLachlan G, Inoue M, Hyde SC, Moran C, Meng C, Paul-Smith M, Pringle I, Pytel K, Rodriguez-Martinez A, Stevenson B, Tsugumine Set al., 2015, MOVING LENTIVIRAL-BASED GENE THERAPY INTO A FIRST-IN-MAN CF TRIAL, PEDIATRIC PULMONOLOGY, Vol: 50, Pages: 283-283, ISSN: 8755-6863

JOURNAL ARTICLE

Griesenbach U, Alton EWFW, 2015, Recent advances in understanding and managing cystic fibrosis transmembrane conductance regulator dysfunction., F1000Prime Rep, Vol: 7, ISSN: 2051-7599

Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians and has been extensively studied for many decades. The cystic fibrosis transmembrane conductance regulator gene was identified in 1989. It encodes a complex protein which has numerous cellular functions. Our understanding of cystic fibrosis pathophysiology and genetics is constantly expanding and being refined, leading to improved management of the disease and increased life expectancy in affected individuals.

JOURNAL ARTICLE

Griesenbach U, Alton EWFW, Beekman JM, Boyd AC, Chan M, Davies JC, Davies LA, Davidson HE, Dekkers JF, Gea-Sorli S, Gill DR, Hasegawa M, Higgins T, Hyndman L, McLachlan G, Inoue M, Hyde SC, Moran C, Meng C, Paul-Smith MC, Pringle IA, Pytel KM, Rodriguez-Martinez A, Stevenson BJ, Tsugumine Set al., 2015, MOVING LENTIVIRAL-BASED GENE THERAPY INTO A FIRST-IN-MAN CF TRIAL, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A34-A34, ISSN: 0040-6376

CONFERENCE PAPER

Griesenbach U, Pytel KM, Alton EWFW, 2015, Cystic Fibrosis Gene Therapy in the UK and Elsewhere, HUMAN GENE THERAPY, Vol: 26, Pages: 266-275, ISSN: 1043-0342

JOURNAL ARTICLE

Hippolyte S, Keogh R, MacNeill S, Simmonds N, Griesenbach Uet al., 2015, THE FEMALE DISADVANTAGE IN UK CF REGISTRY DATA 2008-2013, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A219-A219, ISSN: 0040-6376

CONFERENCE PAPER

Hyde SC, Alton E, Boyd A, Davies JC, Davies LA, Gill DR, Griesenbach U, Hasegawa M, Inoue M, Pringle IA, Sumner-Jones SGet al., 2015, PRODUCTION OF SIV.F/HN: A NEW LENTIVIRUS VECTOR FOR CF GENE THERAPY, PEDIATRIC PULMONOLOGY, Vol: 50, Pages: 291-291, ISSN: 8755-6863

JOURNAL ARTICLE

Hyde SC, Davies LA, Pringle IA, Inoue M, Hasegawa M, Boyd AC, Griesenbach U, Alton EWFW, Gill DRet al., 2015, Scalable, Animal-Free, Suspension-Based Production of Siv Lentiviral Vectors, 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: NATURE PUBLISHING GROUP, Pages: S35-S36, ISSN: 1525-0016

CONFERENCE PAPER

Leoni G, Wasowicz MY, Chan M, Meng C, Farley R, Brody SL, Inoue M, Hasegawa M, Alton EWFW, Griesenbach Uet al., 2015, Ex Vivo and In Vivo Lentivirus-Mediated Transduction of Airway Epithelial Progenitor Cells, CURRENT GENE THERAPY, Vol: 15, Pages: 581-590, ISSN: 1566-5232

JOURNAL ARTICLE

Nicklin SA, Griesenbach U, Baker AH, 2015, Special Focus Issue on the Annual Meeting of the British Society for Gene and Cell Therapy, HUMAN GENE THERAPY, Vol: 26, Pages: 247-248, ISSN: 1043-0342

JOURNAL ARTICLE

Paul-Smith M, Gelinas J-F, Pytel K, Chan M, Meng C, Cammack L, Pringle I, Inoue M, Hasegawa M, Hyde S, Gill D, Alton E, Griesenbach Uet al., 2015, Therapeutic levels of alpha-1-antitrypsin following gene therapy with F/HN pseudotyped simian immunodeficiency virus, Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT, INC, Pages: A12-A12, ISSN: 1043-0342

CONFERENCE PAPER

Paul-Smith MC, Gelinas J-F, Pytel K, Chan M, Meng C, Cammack L, Cameron L, Moran C, Pringle I, Davies L, Inoue M, Hasegawa M, Hyde SC, Gill DR, Alton E, Griesenbach Uet al., 2015, F/HN Pseudotyped Lentivirus Generates Therapeutically Relevant and Long-Lasting Alpha-1-Antitrypsin Expression in Mouse Lung, 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: NATURE PUBLISHING GROUP, Pages: S147-S147, ISSN: 1525-0016

CONFERENCE PAPER

Paul-Smith MC, Gelinas JF, Pytel K, Chan M, Meng C, Cammack L, Cameron L, Moran C, Pringle I, Davies L, Inoue M, Hasegawa M, Hyde SC, Gill DR, Alton EWFW, Griesenbach Uet al., 2015, GENE THERAPY FOR ALPHA-1-ANTITRYPSIN DEFICIENCY USING A PSEUDOTYPED LENTIVIRUS VECTOR, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A72-A73, ISSN: 0040-6376

CONFERENCE PAPER

Pytel KM, Paul-Smith M, McIntosh J, Chan M, Meng C, Pringle I, Davies L, Inoue M, Hasegawa M, Hyde SC, Gill DR, Nathwani AC, Alton EWFW, Griesenbach Uet al., 2015, Production of Therapeutically Relevant Levels of FVIII After Transduction of Lungs With F/HN-Pseudotyped Lentivirus, 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: NATURE PUBLISHING GROUP, Pages: S68-S68, ISSN: 1525-0016

CONFERENCE PAPER

Pytel KM, Paul-Smith MC, McIntosh J, Chan M, Meng C, Pringle I, Davis L, Inoue M, Hasegawa M, Hyde SC, Gill DR, Nathwani AC, Alton EWFW, Griesenbach Uet al., 2015, RSIV. F/HN-MEDIATED GENE THERAPY ENABLES LUNGS TO PRODUCE THERAPEUTICALLY RELEVANT LEVELS OF FVIII, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A67-A67, ISSN: 0040-6376

CONFERENCE PAPER

Pytel KM, Smith MP, McIntosh J, Chan M, Meng C, Pringle I, Davies L, Inoue M, Hasegawa M, Hyde SC, Gill DR, Nathwani AC, Alton E, Griesenbach Uet al., 2015, Production of FVIII in the lungs, Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT, INC, Pages: A7-A7, ISSN: 1043-0342

CONFERENCE PAPER

Alton EWFW, Boyd AC, Cheng SH, Davies JC, Davies LA, Dayan A, Gill DR, Griesenbach U, Higgins T, Hyde SC, Innes JA, McLachlan G, Porteous D, Pringle I, Scheule RK, Sumner-Jones Set al., 2014, Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung, GENE THERAPY, Vol: 21, Pages: 89-95, ISSN: 0969-7128

JOURNAL ARTICLE

Griesenbach U, Alton EW, Boyd A, Calcedo R, Cheng SH, Cunningham S, Davies JC, Dewar M, Gill DR, Doherty A, Higgins TE, Hyde SC, Innes J, Manvell M, Meng C, Limberis MP, Punch E, Scheule RK, Soussi N, Soussi S, Wilson Jet al., 2014, IMMUNE RESPONSES TO SINGLE AND REPEATED ADMINISTRATION OF PGM169/GL67A: THE UK CF GENE THERAPY CONSORTIUM CLINICAL TRIALS, PEDIATRIC PULMONOLOGY, Vol: 49, Pages: 297-297, ISSN: 8755-6863

JOURNAL ARTICLE

Griesenbach U, Alton EWFW, Armstrong DK, Bayfield KJ, Brand J, Boyd AC, Carvelli PRM, Cheng S, Cunningham S, Davies JC, Dewar M, Elgmati H, Gibson JS, Gill DR, Doherty A, Greening AP, Harman KML, Higgins T, Hyde SC, Leiton J, McLean A, Manvell M, Meng C, Punch E, Saunders CJ, Scheule R, Soussi N, Soussi S, Spearing EJ, Sumner-Jones S, Ureta R, Wasowicz MW, Waller M, Watt NS, Innes JAet al., 2014, Assessment of immune responses to single and repeat dose aeroslisation of the non-viral formualtion PGM169/GL67A in cystic fibrosis patients, ESGCT and NVGCT Collaborative Congress, Publisher: MARY ANN LIEBERT, INC, Pages: A110-A111, ISSN: 1043-0342

CONFERENCE PAPER

Griesenbach U, Alton EWFW, Armstrong DK, Bayfield KJ, Brand J, Boyd AC, Carvelli PRM, Cheng S, Cunningham S, Davies JC, Dewar M, Elgmati H, Gibson JS, Gill DR, Doherty A, Greening AP, Harman KML, Higgins T, Hyde SC, Leiton J, McLean A, Manvell M, Meng C, Punch E, Saunders CJ, Scheule R, Soussi N, Soussi S, Spearing EJ, Sumner-Jones S, Ureta R, Wasowicz MW, Waller M, Watt NS, Innes JAet al., 2014, Results of a Phase IIb non-viral gene therapy trial from the UK CF Gene Therapy Consortium, ESGCT and NVGCT Collaborative Congress, Publisher: MARY ANN LIEBERT, INC, Pages: A51-A51, ISSN: 1043-0342

CONFERENCE PAPER

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