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@article{Dawson:2012:10.1371/journal.pone.0031141,
author = {Dawson, JC and Bruche, S and Spence, HJ and Braga, VMM and Machesky, LM},
doi = {10.1371/journal.pone.0031141},
journal = {PLoS One},
title = {Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1},
url = {http://dx.doi.org/10.1371/journal.pone.0031141},
volume = {7},
year = {2012}
}

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TY  - JOUR
AB  - Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread. We show here that Metastasis suppressor-1 (Mtss1; Missing in Metastasis, MIM), a member of the IMD-family of proteins, inhibits cell-cell junction disassembly in wound healing or HGF-induced scatter assays by enhancing cell-cell junction strength. Mtss1 not only makes cells more resistant to cell-cell junction disassembly, but also accelerates the kinetics of adherens junction assembly. Mtss1 drives enhanced junction formation specifically by elevating Rac-GTP. Lastly, we show that Mtss1 depletion reduces recruitment of F-actin at cell-cell junctions. We thus propose that Mtss1 promotes Rac1 activation and actin recruitment driving junction maintenance. We suggest that the observed loss of Mtss1 in cancers may compromise junction stability and thus promote EMT and metastasis.
AU  - Dawson,JC
AU  - Bruche,S
AU  - Spence,HJ
AU  - Braga,VMM
AU  - Machesky,LM
DO  - 10.1371/journal.pone.0031141
PY  - 2012///
SN  - 1932-6203
TI  - Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0031141
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22479308
UR  - http://hdl.handle.net/10044/1/26251
VL  - 7
ER  -

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