Imperial College London
Alternate

ProfessorVaniaBraga

Faculty of Medicine, National Heart & Lung Institute

Professor of Cellular Signalling
 
 
 
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Contact

 

+44 (0)20 7594 3233v.braga

 
 
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Location

 

Office no. 105Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Serva:2012:10.1371/journal.pone.0052555,
author = {Serva, A and Knapp, B and Claas, C and Tsai, YC and Lisauskas, T and Matula, P and Harder, N and Kaderali, L and Rohr, K and Erfle, H and Eils, R and Braga, VMM and Starkuviene, V},
doi = {10.1371/journal.pone.0052555},
journal = {PLoS ONE},
title = {miR-17-5p regulates endocytic trafficking through targeting TBC1D2/ Armus},
url = {http://dx.doi.org/10.1371/journal.pone.0052555},
volume = {7},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - miRNA cluster miR-17-92 is known as oncomir-1 due to its potent oncogenic function. miR-17-92 is a polycistronic clusterthat encodes 6 miRNAs, and can both facilitate and inhibit cell proliferation. Known targets of miRNAs encoded by thiscluster are largely regulators of cell cycle progression and apoptosis. Here, we show that miRNAs encoded by this clusterand sharing the seed sequence of miR-17 exert their influence on one of the most essential cellular processes – endocytictrafficking. By mRNA expression analysis we identified that regulation of endocytic trafficking by miR-17 can potentially beachieved by targeting of a number of trafficking regulators. We have thoroughly validated TBC1D2/Armus, a GAP of Rab7GTPase, as a novel target of miR-17. Our study reveals regulation of endocytic trafficking as a novel function of miR-17,which might act cooperatively with other functions of miR-17 and related miRNAs in health and disease.
AU  - Serva,A
AU  - Knapp,B
AU  - Claas,C
AU  - Tsai,YC
AU  - Lisauskas,T
AU  - Matula,P
AU  - Harder,N
AU  - Kaderali,L
AU  - Rohr,K
AU  - Erfle,H
AU  - Eils,R
AU  - Braga,VMM
AU  - Starkuviene,V
DO  - 10.1371/journal.pone.0052555
PY  - 2012///
SN  - 1932-6203
TI  - miR-17-5p regulates endocytic trafficking through targeting TBC1D2/ Armus
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0052555
UR  - http://hdl.handle.net/10044/1/53982
VL  - 7
ER  -
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