Imperial College London
Alternate

ProfessorVaniaBraga

Faculty of Medicine, National Heart & Lung Institute

Professor of Cellular Signalling
 
 
 
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Contact

 

+44 (0)20 7594 3233v.braga

 
 
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Location

 

Office no. 105Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Braga:2016:10.1016/j.ceb.2016.07.006,
author = {Braga, V},
doi = {10.1016/j.ceb.2016.07.006},
journal = {Current Opinion in Cell Biology},
pages = {138--145},
title = {Spatial integration of E-cadherin adhesion, signalling and the epithelial cytoskeleton},
url = {http://dx.doi.org/10.1016/j.ceb.2016.07.006},
volume = {42},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The characteristic tall and elongated shape of epithelial cells requires specialized adhesive structures and a distinct organization of cytoskeletal filaments. Cytoskeletal networks coordinate a precise organization of adhesive and signalling complexes along cell-cell contacts and enable exquisite strong cohesion among epithelial cells. E-cadherin, a calcium-dependent adhesion receptor, is an essential adhesive system in epithelia and its dynamic regulation and pathways that stabilize cell-cell adhesion have been extensively studied. This review highlights the less understood mechanisms underlying how cadherin receptor signalling drives cytoskeletal rearrangements which ultimately define the epithelial cell shape. In the past two years, new insights identify specific actin-binding proteins and regulators of the epithelial cytoskeleton as a framework to support junction dynamics, plasticity and maintenance.
AU  - Braga,V
DO  - 10.1016/j.ceb.2016.07.006
EP  - 145
PY  - 2016///
SN  - 1879-0410
SP  - 138
TI  - Spatial integration of E-cadherin adhesion, signalling and the epithelial cytoskeleton
T2  - Current Opinion in Cell Biology
UR  - http://dx.doi.org/10.1016/j.ceb.2016.07.006
UR  - http://hdl.handle.net/10044/1/41431
VL  - 42
ER  -
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