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@article{Masca:2015:10.7554/eLife.05519,
author = {Masca, NGD and Hensor, EMA and Cornelius, VR and Buffa, FM and Marriott, HM and Eales, JM and Messenger, MP and Anderson, AE and Boot, C and Bunce, C and Goldin, RD and Harris, J and Hinchliffe, RF and Junaid, H and Kingston, S and Martin-Ruiz, C and Nelson, CP and Peacock, J and Seed, PT and Shinkins, B and Staples, KJ and Toombs, J and Wright, AKA and Teare, MD},
doi = {10.7554/eLife.05519},
journal = {eLife},
title = {RIPOSTE: a framework for improving the design and analysis of laboratory-based research},
url = {http://dx.doi.org/10.7554/eLife.05519},
volume = {4},
year = {2015}
}

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TY  - JOUR
AB  - Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contribute to this problem. The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, to reduce irreproducibility. This framework is intended for use during the early stages of a research project, when specific questions or hypotheses are proposed. The essential points within the framework are explained and illustrated using three examples (a medical equipment test, a macrophage study and a gene expression study). Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results.
AU  - Masca,NGD
AU  - Hensor,EMA
AU  - Cornelius,VR
AU  - Buffa,FM
AU  - Marriott,HM
AU  - Eales,JM
AU  - Messenger,MP
AU  - Anderson,AE
AU  - Boot,C
AU  - Bunce,C
AU  - Goldin,RD
AU  - Harris,J
AU  - Hinchliffe,RF
AU  - Junaid,H
AU  - Kingston,S
AU  - Martin-Ruiz,C
AU  - Nelson,CP
AU  - Peacock,J
AU  - Seed,PT
AU  - Shinkins,B
AU  - Staples,KJ
AU  - Toombs,J
AU  - Wright,AKA
AU  - Teare,MD
DO  - 10.7554/eLife.05519
PY  - 2015///
SN  - 2050-084X
TI  - RIPOSTE: a framework for improving the design and analysis of laboratory-based research
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.05519
UR  - http://hdl.handle.net/10044/1/34439
VL  - 4
ER  -

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