Imperial College London
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ProfessorVictoriaCornelius

Faculty of Medicine, School of Public Health

Professor in Medical Statistics and Trials Methodology
 
 
 
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Contact

 

+44 (0)20 7594 1218v.cornelius

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

111Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hallward:2016:10.1053/j.jvca.2016.02.004,
author = {Hallward, G and Balani, N and McCorkell, S and Roxburgh, J and Cornelius, VR},
doi = {10.1053/j.jvca.2016.02.004},
journal = {Journal of Cardiothoracic and Vascular Anesthesia},
pages = {901--908},
title = {The Relationship Between Preoperative Hemoglobin Concentration, Use of Hospital Resources, and Outcomes in Cardiac Surgery},
url = {http://dx.doi.org/10.1053/j.jvca.2016.02.004},
volume = {30},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesPreoperative anemia is an established risk factor associated with adverse perioperative outcomes after cardiac surgery. However, limited information exists regarding the relationship between preoperative hemoglobin concentration and outcomes. The aim of this study was to investigate how outcomes are affected by preoperative hemoglobin concentration in a cohort of patients undergoing cardiac surgery.DesignA retrospective, observational cohort study.SettingA single-center tertiary referral hospital.ParticipantsThe study comprised 1,972 adult patients undergoing elective and nonelective cardiac surgery.InterventionsThe independent relationship of preoperative hemoglobin concentration was explored on blood transfusion rates, return to the operating room for bleeding and/or cardiac tamponade, postoperative intensive care unit (ICU) and in-hospital length of stay, and mortality.Measurements and Main ResultsThe overall prevalence of anemia was 32% (629/1,972 patients). For every 1-unit increase in hemoglobin (g/dL), blood transfusion requirements were reduced by 11%, 8%, and 3% for red blood cell units, platelet pools, and fresh frozen plasma units, respectively (adjusted incident rate ratio 0.89 [95% CI 0.87-0.91], 0.92 [0.88-0.97], and 0.97 [0.96-0.99]). For each 1-unit increase in hemoglobin (g/dL), the probability (over time) of discharge from the ICU and hospital increased (adjusted hazard ratio estimates 1.04 [1.00-1.08] and 1.12 [1.12-1.16], respectively).ConclusionsA lower preoperative hemoglobin concentration resulted in increased use of hospital resources after cardiac surgery. Each g/dL unit fall in preoperative hemoglobin concentration resulted in increased blood transfusion requirements and increased postoperative ICU and hospital length of stay.
AU  - Hallward,G
AU  - Balani,N
AU  - McCorkell,S
AU  - Roxburgh,J
AU  - Cornelius,VR
DO  - 10.1053/j.jvca.2016.02.004
EP  - 908
PY  - 2016///
SN  - 1532-8422
SP  - 901
TI  - The Relationship Between Preoperative Hemoglobin Concentration, Use of Hospital Resources, and Outcomes in Cardiac Surgery
T2  - Journal of Cardiothoracic and Vascular Anesthesia
UR  - http://dx.doi.org/10.1053/j.jvca.2016.02.004
VL  - 30
ER  -
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