Imperial College London
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ProfessorVictoriaCornelius

Faculty of Medicine, School of Public Health

Professor in Medical Statistics and Trials Methodology
 
 
 
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Contact

 

+44 (0)20 7594 1218v.cornelius

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

111Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Harris:2017,
author = {Harris, J and Cornelius, V and Ream, E and Armes, J and Cheevers, K},
journal = {Supportive Care in Cancer},
pages = {2321--2333},
title = {Anxiety after treatment for non-metastatic breast cancer: a systematic review to identify risk factors and evaluate multivariate model development},
url = {http://hdl.handle.net/10044/1/49733},
volume = {25},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeThe purpose of this review was to identify potential candidate predictors of anxiety in women with early-stage breast cancer (BC) after adjuvant treatments and evaluate methodological development of existing multivariable models to inform the future development of a predictive risk stratification model (PRSM).MethodsDatabases (MEDLINE, Web of Science, CINAHL, CENTRAL and PsycINFO) were searched from inception to November 2015. Eligible studies were prospective, recruited women with stage 0–3 BC, used a validated anxiety outcome ≥3 months post-treatment completion and used multivariable prediction models. Internationally accepted quality standards were used to assess predictive risk of bias and strength of evidence.ResultsSeven studies were identified: five were observational cohorts and two secondary analyses of RCTs. Variability of measurement and selective reporting precluded meta-analysis. Twenty-one candidate predictors were identified in total. Younger age and previous mental health problems were identified as risk factors in ≥3 studies. Clinical variables (e.g. treatment, tumour grade) were not identified as predictors in any studies. No studies adhered to all quality standards.ConclusionsPre-existing vulnerability to mental health problems and younger age increased the risk of anxiety after completion of treatment for BC survivors, but there was no evidence that chemotherapy was a predictor. Multiple predictors were identified but many lacked reproducibility or were not measured across studies, and inadequate reporting did not allow full evaluation of the multivariable models. The use of quality standards in the development of PRSM within supportive cancer care would improve model quality and performance, thereby allowing professionals to better target support for patients.
AU  - Harris,J
AU  - Cornelius,V
AU  - Ream,E
AU  - Armes,J
AU  - Cheevers,K
EP  - 2333
PY  - 2017///
SN  - 0941-4355
SP  - 2321
TI  - Anxiety after treatment for non-metastatic breast cancer: a systematic review to identify risk factors and evaluate multivariate model development
T2  - Supportive Care in Cancer
UR  - http://hdl.handle.net/10044/1/49733
VL  - 25
ER  -
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