Imperial College London

DrVladimirPelicic

Faculty of MedicineDepartment of Medicine

Reader in Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 2080v.pelicic Website

 
 
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Location

 

3.20Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Linhartova:2006:10.1111/j.1574-6968.2006.00407.x,
author = {Linhartova, I and Basler, M and Ichikawa, J and Pelicic, V and Osicka, R and Lory, S and Nassif, X and Sebo, P},
doi = {10.1111/j.1574-6968.2006.00407.x},
journal = {FEMS Microbiol Lett},
pages = {109--118},
title = {Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells.},
url = {http://dx.doi.org/10.1111/j.1574-6968.2006.00407.x},
volume = {263},
year = {2006}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Neisseria meningitidis colonizes the human nasopharynx and occasionally causes lethal or damaging septicemia and meningitis. Here, we examined the adherence-mediated signaling of meningococci to human cells by comparing gene expression profiles of human umbilical vein endothelial cells (HUVEC) infected by adherent wild-type, frpC-deficient mutant, or the nonadherent (DeltapilD) N. meningitidis. Pili-mediated adhesion of meningococci resulted in alterations of expression levels of human genes known to regulate apoptosis, cell proliferation, inflammatory response, adhesion and genes for signaling pathway proteins such as TGF-beta/Smad, Wnt/beta-catenin and Notch/Jagged. This reveals that adhering piliated meningocci manipulate host signaling pathways controlling cell proliferation while establishing a commensal relationship.
AU - Linhartova,I
AU - Basler,M
AU - Ichikawa,J
AU - Pelicic,V
AU - Osicka,R
AU - Lory,S
AU - Nassif,X
AU - Sebo,P
DO - 10.1111/j.1574-6968.2006.00407.x
EP - 118
PY - 2006///
SN - 0378-1097
SP - 109
TI - Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells.
T2 - FEMS Microbiol Lett
UR - http://dx.doi.org/10.1111/j.1574-6968.2006.00407.x
UR - https://www.ncbi.nlm.nih.gov/pubmed/16958858
UR - http://hdl.handle.net/10044/1/26776
VL - 263
ER -