Imperial College London

DrVladimirPelicic

Faculty of MedicineDepartment of Medicine

Reader in Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 2080v.pelicic Website

 
 
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Location

 

3.20Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Loh:2013:10.1038/nature12616,
author = {Loh, E and Kugelberg, E and Tracy, A and Zhang, Q and Gollan, B and Ewles, H and Chalmers, R and Pelicic, V and Tang, CM},
doi = {10.1038/nature12616},
journal = {Nature},
pages = {237--240},
title = {Temperature triggers immune evasion by Neisseria meningitidis.},
url = {http://dx.doi.org/10.1038/nature12616},
volume = {502},
year = {2013}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Neisseria meningitidis has several strategies to evade complement-mediated killing, and these contribute to its ability to cause septicaemic disease and meningitis. However, the meningococcus is primarily an obligate commensal of the human nasopharynx, and it is unclear why the bacterium has evolved exquisite mechanisms to avoid host immunity. Here we demonstrate that mechanisms of meningococcal immune evasion and resistance against complement increase in response to an increase in ambient temperature. We have identified three independent RNA thermosensors located in the 5' untranslated regions of genes necessary for capsule biosynthesis, the expression of factor H binding protein, and sialylation of lipopolysaccharide, which are essential for meningococcal resistance against immune killing. Therefore increased temperature (which occurs during inflammation) acts as a 'danger signal' for the meningococcus, enhancing its defence against human immune killing. Infection with viral pathogens, such as influenza, leads to inflammation in the nasopharynx with an increased temperature and recruitment of immune effectors. Thermoregulation of immune defence could offer an adaptive advantage to the meningococcus during co-infection with other pathogens, and promote the emergence of virulence in an otherwise commensal bacterium.
AU - Loh,E
AU - Kugelberg,E
AU - Tracy,A
AU - Zhang,Q
AU - Gollan,B
AU - Ewles,H
AU - Chalmers,R
AU - Pelicic,V
AU - Tang,CM
DO - 10.1038/nature12616
EP - 240
PY - 2013///
SP - 237
TI - Temperature triggers immune evasion by Neisseria meningitidis.
T2 - Nature
UR - http://dx.doi.org/10.1038/nature12616
UR - https://www.ncbi.nlm.nih.gov/pubmed/24067614
UR - http://hdl.handle.net/10044/1/22029
VL - 502
ER -