Imperial College London
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DrVictoriaSalem

Faculty of Engineering, Department of Bioengineering

Clinical Senior Lecturer in Diabetes and Endocrinology
 
 
 
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Contact

 

v.salem

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Muniangi-Muhitu:2020:10.3389/fendo.2020.582936,
author = {Muniangi-Muhitu, H and Akalestou, E and Salem, V and Misra, S and Oliver, NS and Rutter, GA},
doi = {10.3389/fendo.2020.582936},
journal = {Frontiers in Endocrinology},
title = {Covid-19 and diabetes: a complex bidirectional relationship},
url = {http://dx.doi.org/10.3389/fendo.2020.582936},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Covid-19 is a recently-emerged infectious disease caused by the novel severe acute respiratory syndrome coronavirus SARS-CoV2. SARS-CoV2 differs from previous coronavirus infections (SARS and MERS) due to its high infectivity (reproduction value, R0, typically 2-4) and pre- or asymptomatic transmission, properties that have contributed to the current global Covid-19 pandemic. Identified risk factors for disease severity and death from SARS-Cov2 infection include older age, male sex, diabetes, obesity and hypertension. The reasons for these associations are still largely obscure. Evidence is also emerging that SARS-CoV2 infection exacerbates the underlying pathophysiology of hyperglycemia in people with diabetes. Here, we discuss potential mechanisms through which diabetes may affect the risk of more severe outcomes in Covid-19 and, additionally, how diabetic emergencies and longer term pathology may be aggravated by infection with the virus. We consider roles for the immune system, the observed phenomenon of microangiopathy in severe Covid-19 infection and the potential for direct viral toxicity on metabolically-relevant tissues including pancreatic beta cells and targets of insulin action.
AU  - Muniangi-Muhitu,H
AU  - Akalestou,E
AU  - Salem,V
AU  - Misra,S
AU  - Oliver,NS
AU  - Rutter,GA
DO  - 10.3389/fendo.2020.582936
PY  - 2020///
SN  - 1664-2392
TI  - Covid-19 and diabetes: a complex bidirectional relationship
T2  - Frontiers in Endocrinology
UR  - http://dx.doi.org/10.3389/fendo.2020.582936
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33133024
UR  - http://hdl.handle.net/10044/1/83655
VL  - 11
ER  -
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