Imperial College London
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DrVictoriaSalem

Faculty of Engineering, Department of Bioengineering

Clinical Senior Lecturer in Diabetes and Endocrinology
 
 
 
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Contact

 

v.salem

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{De:2012:2012/764017,
author = {De, Silva A and Salem, V and Matthews, PM and Dhillo, WS},
doi = {2012/764017},
journal = {EXPERIMENTAL DIABETES RESEARCH},
title = {The Use of Functional MRI to Study Appetite Control in the CNS},
url = {http://dx.doi.org/10.1155/2012/764017},
volume = {2012},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Functional magnetic resonance imaging (fMRI) has provided the opportunity to safely investigate the workings of the humanbrain. This paper focuses on its use in the field of human appetitive behaviour and its impact in obesity research. In the presentabsence of any safe or effective centrally acting appetite suppressants, a better understanding of how appetite is controlled is vitalfor the development of new antiobesity pharmacotherapies. Early functional imaging techniques revealed an attenuation of brainreward area activity in response to visual food stimuli when humans are fed—in other words, the physiological state of hungersomehow increases the appeal value of food. Later studies have investigated the action of appetite modulating hormones on thefMRI signal, showing how the attenuation of brain reward region activity that follows feeding can be recreated in the fasted state bythe administration of anorectic gut hormones. Furthermore, differences in brain activity between obese and lean individuals haveprovided clues about the possible aetiology of overeating. The hypothalamus acts as a central gateway modulating homeostatic andnonhomeostatic drives to eat. As fMRI techniques constantly improve, functional data regarding the role of this small but hugelyimportant structure in appetite control is emerging.
AU  - De,Silva A
AU  - Salem,V
AU  - Matthews,PM
AU  - Dhillo,WS
DO  - 2012/764017
PY  - 2012///
SN  - 1687-5214
TI  - The Use of Functional MRI to Study Appetite Control in the CNS
T2  - EXPERIMENTAL DIABETES RESEARCH
UR  - http://dx.doi.org/10.1155/2012/764017
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305624000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/57624
VL  - 2012
ER  -
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