Imperial College London

DrVahidShahrezaei

Faculty of Natural SciencesDepartment of Mathematics

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 8516v.shahrezaei Website

 
 
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Location

 

301BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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29 results found

Priestman M, Thomas P, Robertson BD, Shahrezaei Vet al., 2017, Mycobacteria Modify Their Cell Size Control under Sub-Optimal Carbon Sources., Front Cell Dev Biol, Vol: 5, ISSN: 2296-634X

The decision to divide is the most important one that any cell must make. Recent single cell studies suggest that most bacteria follow an "adder" model of cell size control, incorporating a fixed amount of cell wall material before dividing. Mycobacteria, including the causative agent of tuberculosis Mycobacterium tuberculosis, are known to divide asymmetrically resulting in heterogeneity in growth rate, doubling time, and other growth characteristics in daughter cells. The interplay between asymmetric cell division and adder size control has not been extensively investigated. Moreover, the impact of changes in the environment on growth rate and cell size control have not been addressed for mycobacteria. Here, we utilize time-lapse microscopy coupled with microfluidics to track live Mycobacterium smegmatis cells as they grow and divide over multiple generations, under a variety of growth conditions. We demonstrate that, under optimal conditions, M. smegmatis cells robustly follow the adder principle, with constant added length per generation independent of birth size, growth rate, and inherited pole age. However, the nature of the carbon source induces deviations from the adder model in a manner that is dependent on pole age. Understanding how mycobacteria maintain cell size homoeostasis may provide crucial targets for the development of drugs for the treatment of tuberculosis, which remains a leading cause of global mortality.

JOURNAL ARTICLE

Sturrock M, Li S, Shahrezaei V, 2017, The influence of nuclear compartmentalisation on stochastic dynamics of self-repressing gene expression, JOURNAL OF THEORETICAL BIOLOGY, Vol: 424, Pages: 55-72, ISSN: 0022-5193

JOURNAL ARTICLE

Archer N, Walsh MD, Shahrezaei V, Hebenstreit Det al., 2016, Modeling Enzyme Processivity Reveals that RNA-Seq Libraries Are Biased in Characteristic and Correctable Ways, CELL SYSTEMS, Vol: 3, Pages: 467-+, ISSN: 2405-4712

JOURNAL ARTICLE

Shahrezaei V, Marguerat S, 2015, Connecting growth with gene expression: of noise and numbers, CURRENT OPINION IN MICROBIOLOGY, Vol: 25, Pages: 127-135, ISSN: 1369-5274

JOURNAL ARTICLE

Smith S, Shahrezaei V, 2015, General transient solution of the one-step master equation in one dimension, PHYSICAL REVIEW E, Vol: 91, ISSN: 2470-0045

JOURNAL ARTICLE

Uhia I, Williams KJ, Shahrezaei V, Robertson BDet al., 2015, Mycobacterial Growth, COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, Vol: 5, ISSN: 2157-1422

JOURNAL ARTICLE

Dushek O, Lellouch AC, Vaux DJ, Shahrezaei Vet al., 2014, Biosensor Architectures for High-Fidelity Reporting of Cellular Signaling, BIOPHYSICAL JOURNAL, Vol: 107, Pages: 773-782, ISSN: 0006-3495

JOURNAL ARTICLE

Robb ML, Shahrezaei V, 2014, Stochastic Cellular Fate Decision Making by Multiple Infecting Lambda Phage, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

Delaney KR, Shahrezaei V, 2013, Uncaging calcium in neurons., Cold Spring Harb Protoc, Vol: 2013, Pages: 1115-1124

Changes in intracellular free calcium concentration (Δ[Ca(2+)]i) driving physiological events such as neurotransmitter release or Ca(2+)-dependent currents can be monitored using Ca(2+)-sensitive fluorescent dyes. Although these dyes can correlate Δ[Ca(2+)]i with a physiological event, they cannot directly test for causality between changes in [Ca(2+)]i and that event. Photolabile Ca(2+) chelators are Ca(2+)-binding molecules that can alter and, to a certain extent, control [Ca(2+)]i in an inducible manner and with temporal and spatial resolution that surpasses microinjection or ionophore application. Here we discuss the properties of caged Ca(2+) compounds as well as some practical considerations for their use in neuronal cells, where they have proven particularly effective.

JOURNAL ARTICLE

Joyce G, Williams KJ, Robb M, Noens E, Tizzano B, Shahrezaei V, Robertson BDet al., 2012, Cell Division Site Placement and Asymmetric Growth in Mycobacteria, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Schley D, Tanaka RJ, Leungchavaphongse K, Shahrezaei V, Ward J, Grant C, Charleston B, Rhodes CJet al., 2012, Modelling the Influence of Foot-and-Mouth Disease Vaccine Antigen Stability and Dose on the Bovine Immune Response, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Szomolay B, Shahrezaei V, 2012, Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation, BMC SYSTEMS BIOLOGY, Vol: 6, ISSN: 1752-0509

JOURNAL ARTICLE

Dushek O, van der Merwe PA, Shahrezaei V, 2011, Ultrasensitivity in Multisite Phosphorylation of Membrane-Anchored Proteins, BIOPHYSICAL JOURNAL, Vol: 100, Pages: 1189-1197, ISSN: 0006-3495

JOURNAL ARTICLE

Malleshaiah MK, Shahrezaei V, Swain PS, Michnick SWet al., 2010, The scaffold protein Ste5 directly controls a switch-like mating decision in yeast, NATURE, Vol: 465, Pages: 101-105, ISSN: 0028-0836

JOURNAL ARTICLE

Ollivier JF, Shahrezaei V, Swain PS, 2010, Scalable Rule-Based Modelling of Allosteric Proteins and Biochemical Networks, PLOS COMPUTATIONAL BIOLOGY, Vol: 6, ISSN: 1553-734X

JOURNAL ARTICLE

Shahrezaei V, Ollivier JF, Swain PS, 2008, Colored extrinsic fluctuations and stochastic gene expression, MOLECULAR SYSTEMS BIOLOGY, Vol: 4, ISSN: 1744-4292

JOURNAL ARTICLE

Shahrezaei V, Swain PS, 2008, The stochastic nature of biochemical networks, CURRENT OPINION IN BIOTECHNOLOGY, Vol: 19, Pages: 369-374, ISSN: 0958-1669

JOURNAL ARTICLE

Shahrezaei V, Swain PS, 2008, Analytical distributions for stochastic gene expression, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 105, Pages: 17256-17261, ISSN: 0027-8424

JOURNAL ARTICLE

Shahrezaei V, Cao A, Delaney KR, 2006, Ca2+ from one or two channels controls fusion of a single vesicle at the frog neuromuscular junction, JOURNAL OF NEUROSCIENCE, Vol: 26, Pages: 13240-13249, ISSN: 0270-6474

JOURNAL ARTICLE

Shahrezaei V, Delaney KR, 2005, Brevity of the Ca2+ microdomain and active zone geometry prevent Ca2+-sensor saturation for neurotransmitter release, JOURNAL OF NEUROPHYSIOLOGY, Vol: 94, Pages: 1912-1919, ISSN: 0022-3077

JOURNAL ARTICLE

Otsu Y, Shahrezaei V, Li B, Raymond LA, Delaney KR, Murphy THet al., 2004, Competition between phasic and asynchronous release for recovered synaptic vesicles at developing hippocampal autaptic synapses, JOURNAL OF NEUROSCIENCE, Vol: 24, Pages: 420-433, ISSN: 0270-6474

JOURNAL ARTICLE

Shahrezaei V, Delaney K, 2004, Effects of brief calcium transients and non-equilibrium binding to the exocytotic machinery in modulating fast neurotransmitter release., 48th Annual Meeting of the Biophysical Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 548A-548A, ISSN: 0006-3495

CONFERENCE PAPER

Shahrezaei V, Delaney KR, 2004, Consequences of molecular-level Ca2+ channel and synaptic vesicle colocalization for the Ca2+ microdomain and neurotransmitter exocytosis: A Monte Carlo study, BIOPHYSICAL JOURNAL, Vol: 87, Pages: 2352-2364, ISSN: 0006-3495

JOURNAL ARTICLE

Shahrezaei V, Ejtehadi MR, 2000, Geometry selects highly designable structures, JOURNAL OF CHEMICAL PHYSICS, Vol: 113, Pages: 6437-6442, ISSN: 0021-9606

JOURNAL ARTICLE

Ejtehadi MR, Hamedani N, Shahrezaei V, 1999, Geometrically reduced number of protein ground state candidates, PHYSICAL REVIEW LETTERS, Vol: 82, Pages: 4723-4726, ISSN: 0031-9007

JOURNAL ARTICLE

Shahrezaei V, Hamedani N, Ejtehadi MR, 1999, Protein ground state candidates in a simple model: An enumeration study, PHYSICAL REVIEW E, Vol: 60, Pages: 4629-4636, ISSN: 1063-651X

JOURNAL ARTICLE

Ejtehadi MR, Hamedani N, Seyed-Allaei H, Shahrezaei V, Yahyanejad Met al., 1998, Preferred structures and monomer-monomer interactions, Workshop on Monte Carlo Approach to Biopolymers and Protein Folding, Publisher: WORLD SCIENTIFIC PUBL CO PTE LTD, Pages: 242-254

CONFERENCE PAPER

Ejtehadi MR, Hamedani N, Seyed-Allaei H, Shahrezaei V, Yahyanejad Met al., 1998, Stability of preferable structures for a hydrophobic-polar model of protein folding, PHYSICAL REVIEW E, Vol: 57, Pages: 3298-3301, ISSN: 1063-651X

JOURNAL ARTICLE

Ejtehadi MR, Hamedani N, Seyed-Allaei H, Shahrezaei V, Yahyanejad Met al., 1998, Highly designable protein structures and inter-monomer interactions, JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, Vol: 31, Pages: 6141-6155, ISSN: 0305-4470

JOURNAL ARTICLE

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