119 results found
Terzidou V, Lim S, Pirianov G, et al., 2009, Rule and Regulation of the Oxytocin/Oxytocin Receptor (OT/OTR) System in Human Amnion and Labour, Pages: 121A-122A, ISSN: 1933-7191
Terzidou VT, 2009, Endocrinology of parturition and preparation for labour, Fetal and Maternal Medicine Review, Vol: 20, Pages: 67-96, ISSN: 0965-5395
Pirianov G, Waddington SN, Lindstrom TM, et al., 2009, The Cyclopentenone 15-Deoxy-Delta(12,14)-Prostaglandin J(2) Delays Lipopolysaccharide-Induced Preterm Delivery and Reduces Mortality in the Newborn Mouse, ENDOCRINOLOGY, Vol: 150, Pages: 699-706, ISSN: 0013-7227
Khanjani S, Lim S, Lee YS, et al., 2008, Affymetrix GeneChip microarray analysis of myometrial genes regulated by NF-kappa B, 55th Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 110A-110A
Pirianov G, Terzidou V, Waddington S, et al., 2008, The prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) delays LPS-induced preterm delivery and reduces mortality in the mouse, 55th Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 185A-185A
Pirianov G, Terzidou V, Waddington S, et al., 2008, Inhibition of c-Jun-N-terminal kinase signalling delays LPS-Induced preterm delivery and reduces mortality in the mouse, 55th Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 184A-185A
Terzidou V, Kandola MS, Khanjani S, et al., 2008, Expression of antioxidant defence proteins in human myometrium before and after the onset of labour, 55th Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 109A-109A
Terzidou V, Taher S, Lim S, et al., 2008, Oxytocin receptor expression and function in human amnion, 55th Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 109A-109A
Khanjani S, Lee YS, Terzidou V, et al., 2008, Chromatin immunoprecipitation and EMSA analysis of NF-kappa B and C/EBP synergism on the OTR promoter, 55th Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 106A-106A
Terzidou V, 2007, Preterm labour. Biochemical and endocrinological preparation for parturition., Best Pract Res Clin Obstet Gynaecol, Vol: 21, Pages: 729-756, ISSN: 1521-6934
Preterm delivery is a common obstetric problem occurring in about 1 in 10 of all births. Preterm babies have a high risk of morbidity and mortality. Such births account for 75% of all major neonatal problems. At the other end of the spectrum, prolonged pregnancy is also a subject of concern because it too is associated with increased fetal morbidity and mortality. Despite extensive research, the mechanisms that control the length of human pregnancy and signal the onset of labour have not been fully determined. This chapter will discuss basic principles in the biology of parturition and the regulation of contraction-associated proteins including the oxytocin receptor. The major pathways regulating contractions and the transcriptional regulation of the main genes that are known to be involved in the onset of labour and parturition will be examined. Some new potentially therapeutic strategies for the biochemical management of preterm labour will be discussed.
Terzidou V, 2007, Studies of the expression and regulation of the human oxytocin receptor
Terzidou V, 2006, The human oxytocin receptor is an acute-phase response gene regulated by NF-kB and C/EBP, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 113, Pages: 859-860, ISSN: 1470-0328
Terzidou V, Lee Y, Lindstrom T, et al., 2006, Regulation of the human oxytocin receptor by nuclear factor-kappa B and CCAAT/enhancer-binding protein-beta, J CLIN ENDOCR METAB, Vol: 91, Pages: 2317-2326, ISSN: 0021-972X
Lee YS, Terzidou V, Lindstrom T, et al., 2005, The role of CCAAT/enhancer-binding protein beta in the transcriptional regulation of COX-2 in human amnion, MOL HUM REPROD, Vol: 11, Pages: 853-858, ISSN: 1360-9947
Sooranna SR, Engineer N, Loudon JAZ, et al., 2005, The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: The differential effect of stretch and interleukin-1 beta, J CLIN ENDOCR METAB, Vol: 90, Pages: 3517-3527, ISSN: 0021-972X
Loudon JAZ, Terzidou V, Kandola M, et al., 2005, Preterm rupture of membranes is associated with increased cytokine concentrations, infection and NF kappa B activity but occurs independently of nuclear PR, 52nd Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 254A-254A
Sooranna SR, Engineer N, Terzidou V, et al., 2005, Anisomycin upregulates oxytocin receptor expression in human uterine myocytes., 52nd Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 353A-353A
Terzidou V, Sooranna SR, Kim LU, et al., 2005, Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes, J CLIN ENDOCR METAB, Vol: 90, Pages: 237-246, ISSN: 0021-972X
Lee YS, Terzidou V, Loudon JAZ, et al., 2004, Physical interactions between NF kappa B and C/EBP in human amnion., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 76A-76A, ISSN: 1071-5576
Terzidou V, Soorana SS, Johnson M, et al., 2004, Expression of RIP140 in human primary myocytes in relation to pregnancy, labour and mechanical stretch., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 235A-235A
Terzidou V, Lee YS, Loudon JAZ, et al., 2004, The pattern of activation of labour associated genes in myometrium by inflammatory cytokines and the effect of progesterone., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 336A-336A
Lee YS, Lindstrom T, Terzidou V, et al., 2004, Kinetics of the activation of NFkappB and C/EBP by interleukin 1beta in human amnion and myometrium., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 229A-229A
Terzidou V, Lee YS, Thornton S, et al., 2004, NF-kappa B promoter activity is potentiated by AP-1 c-fos and c-jun transcription factors in human amnion., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 235A-235A
Terzidou V, Christian M, Loudon JAZ, et al., 2003, Nuclear receptor interacting protein 140 (RIP 140) may be involved with the onset of human labour, Journal of Obstetrics and Gynaecology, Vol: 23, ISSN: 0144-3615
Nuclear receptor interacting protein 1 (NRIP1) [also known as receptor interacting protein 140 (RIP140)] interacts with nuclear receptors in a ligand-dependent manner. Transfection studies suggest that it can act as a co-repressor. Knockout mice for RIP140 are completely infertile because of failure of mature follicles to release oocytes at ovulation. Embryo transfer in RIP140−/− mice resulted in normal implantation rates, but the gestation period was longer which implies that RIP140 may have a role in labour. Our object was to explore the possibility that RIP140 is involved as a co-factor in the signalling cascade that precedes the onset of human labour. RIP140 expression was quantified in primary amnion cells before and after the onset of labour (labour− vs. labour+) using real-time RT-PCR. The effect of IL-1β on RIP140 was assessed. To determine the effect of RIP140 upon PR function, 293 T cells and amnion cells were transfected with an MMTV-luc reporter vector (a reporter activated by progesterone/PR binding). Co-transfection experiments with RIP140 expression vectors were performed. Expression of RIP140 is increased threefold in labour+ amnion cells in comparison with labour−amnion cells (P < 0.05). IL-1β treatment had no effect on the expression of RIP140. Transfection studies showed an increase in MMTV promoter activity when cells were co-transfected with PRB expression vector. Co-transfection with RIP140 significantly reduced MMTV luciferase activity. © 2003, Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. All rights reserved.
Terzidou V, Lee YS, Thornton S, et al., 2003, Identification of the response region on the oxytocin receptor (OTR) promoter which is important for the synergistic transactivation of OTR by C/EBPβ and NF-κB transcription factors, Journal of Obstetrics and Gynaecology, Vol: 23, ISSN: 0144-3615
The OTR promoter contains response elements for several transcription factors often associated with inflammation/immune response. We have demonstrated previously that the OTR promoter is activated synergistically by overexpression of C/EBPβ and NF-κB. Our object is to identify the DNA region which mediates this synergy. Electromobility shift assays (EMSAs) showed specific DNA binding to nine OTR-specific C/EBP and 2 NF-κB sites. Single mutants of each site did not affect activation (fivefold) of OTR promoter with overexpressed C/EBPβ or NF-κB and the synergistic transactivation (30–50-fold). Transfections allowed analysis of the functional consequences of various OTR promoter lengths (350 bp, 656 bp and 1061 bp from the transcription start site). The 350 bp promoter did not demonstrate any transactivation with expression vectors for C/EBPβ and NF-κB, whereas the 656 bp promoter showed induction with C/EBPb and NF-kB but no synergy. EMSAs showed that an overlapping C/EBPβ NF-κB site (−961 to −945 bp) binds both transcription factors but the integrity of the C/EBPβ site is required for NF-κB binding. Mutation of the overlapping area or of the two NF-κB sites did not eliminate the synergistic transactivation. © 2003, Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. All rights reserved.
Terzidou V, Bennett PR, 2002, Preterm labour, CURR OPIN OBSTET GYN, Vol: 14, Pages: 105-113, ISSN: 1040-872X
Terzidou V, Bennett P, 2001, Maternal risk factors for fetal and neonatal brain damage, BIOL NEONATE, Vol: 79, Pages: 157-162
Prematurity is probably the major factor associated with brain damage in newborns. Our growing knowledge of the biochemical mechanisms leading to the onset of labour at term allows the biochemical correlates of the epidemiological risk factors for prematurity to be understood. Infection is the major cause of early preterm labour and is now recognised to be a major cause of fetal cerebral damage leading to cerebral palsy. Only some 5% of cerebral palsy is due to intrapartum asphyxia at term. This may occur due to an obstetric catastrophe or through inadequate placental function leading to chronic intrapartum asphyxia. Copyright (C) 2001 S. Karger AG. Basel.
Clark A, Terzidou V, Blanks A, et al., 1999, 5 beta dihydroprogesterone inhibits spontaneous human myometrial contractions in vitro., Birmingham Womens Hospital Meeting, Publisher: BLACKWELL SCIENCE LTD, Pages: 1100-1100, ISSN: 0306-5456
Thornton S, Terzidou V, Clark A, et al., 1999, Progesterone metabolite and spontaneous myometrial contractions in vitro, LANCET, Vol: 353, Pages: 1327-1329, ISSN: 0140-6736
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