Imperial College London

DrVassoTerzidou

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2164v.terzidou

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brown:2018:10.1016/j.trsl.2018.12.005,
author = {Brown, RG and Al-Memar, M and Marchesi, JR and Lee, YS and Smith, A and Chan, D and Lewis, H and Kindinger, L and Terzidou, V and Bourne, T and Bennett, PR and MacIntyre, DA},
doi = {10.1016/j.trsl.2018.12.005},
journal = {Translational Research},
title = {Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabour rupture of the fetal membranes},
url = {http://dx.doi.org/10.1016/j.trsl.2018.12.005},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Vaginal bacterial community composition influences pregnancy outcome. Preterm prelabor rupture of the fetal membranes (PPROM), which precedes 30% of all spontaneous preterm births, is associated with high vaginal bacterial diversity prior to rupture. The point at which vaginal bacterial diversity is established before PPROM is unknown. In this study, we use metataxonomics to longitudinally characterize the vaginal bacterial composition from as early as 6 weeks of gestation in women at high (n=38) and low (n=22) risk of preterm birth who subsequently experience PPROM and in women delivering at term without complications (n=36). Reduced Lactobacillus spp. abundance and high diversity was observed prior to PPROM in 20% and 26% of women at low and high risk of preterm births respectively, but in only 3% of women who delivered at term. PPROM was associated with instability of bacterial community structure during pregnancy and a shift toward higher diversity predominately occurring during the second trimester. This was characterized by increased relative abundance of potentially pathogenic species including Prevotella, Peptoniphilus, Streptococcus, and Dialister. This study identifies reduced Lactobacillus spp. abundance and increasing vaginal bacterial diversity as an early risk factor for PPROM and highlights the need for interventional studies designed to assess the impact of modifying vaginal bacterial composition for the prevention of preterm birth.
AU - Brown,RG
AU - Al-Memar,M
AU - Marchesi,JR
AU - Lee,YS
AU - Smith,A
AU - Chan,D
AU - Lewis,H
AU - Kindinger,L
AU - Terzidou,V
AU - Bourne,T
AU - Bennett,PR
AU - MacIntyre,DA
DO - 10.1016/j.trsl.2018.12.005
PY - 2018///
SN - 1931-5244
TI - Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabour rupture of the fetal membranes
T2 - Translational Research
UR - http://dx.doi.org/10.1016/j.trsl.2018.12.005
UR - http://hdl.handle.net/10044/1/65423
ER -