Imperial College London

DrVassoTerzidou

Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2164v.terzidou

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

111 results found

Carter J, Tribe RM, Sandall J, Shennan AH, Alfirevic Z, Adamson C, Girling J, Tezcan B, Bennett P, Bonney EA, Simpson N, Care AG, Chandiramani M, Daly S, David AL, James CP, Francis HC, Ganapathy R, Greenwold N, Hezelgrave NL, Hillman C, Hoveyda F, Jolly M, Kelly T, Malarselvi M, Patni S, Manktelow BN, Selman T, Shankar LR, Sharp A, Stock SJ, Terzidou V, Tydeman G, Vecsei FAet al., 2018, The Preterm Clinical Network (PCN) Database: A web-based systematic method of collecting data on the care of women at risk of preterm birth, BMC Pregnancy and Childbirth, Vol: 18

© 2018 The Author(s). Background: Despite much research effort, there is a paucity of conclusive evidence in the field of preterm birth prediction and prevention. The methods of monitoring and prevention strategies offered to women at risk vary considerably around the UK and depend on local maternity care provision. It is becoming increasingly recognised that this experience and knowledge, if captured on a larger scale, could be a utilized as a valuable source of evidence for others. The UK Preterm Clinical Network (UKPCN) was established with the aim of improving care and outcomes for women at risk of preterm birth through the sharing of a wealth of experience and knowledge, as well as the building of clinical and research collaboration. The design and development of a bespoke internet-based database was fundamental to achieving this aim. Method: Following consultation with UKPCN members and agreement on a minimal dataset, the Preterm Clinical Network (PCN) Database was constructed to collect data from women at risk of preterm birth and their children. Information Governance and research ethics committee approval was given for the storage of historical as well as prospectively collected data. Collaborating centres have instant access to their own records, while use of pooled data is governed by the PCN Database Access Committee. Applications are welcomed from UKPCN members and other established research groups. The results of investigations using the data are expected to provide insights into the effectiveness of current surveillance practices and preterm birth interventions on a national and international scale, as well as the generation of ideas for innovation and research. To date, 31 sites are registered as Data Collection Centres, four of which are outside the UK. Conclusion: This paper outlines the aims of the PCN Database along with the development process undertaken from the initial idea to live launch.

JOURNAL ARTICLE

Pohl O, Chollet A, Kim SH, Riaposova L, Spézia F, Gervais F, Guillaume P, Lluel P, Méen M, Lemaux F, Terzidou V, Bennett PR, Gotteland J-Pet al., 2018, OBE022, an Oral and Selective Prostaglandin F2 α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor., J Pharmacol Exp Ther, Vol: 366, Pages: 349-364

Preterm birth is the major challenge in obstetrics, affecting ∼10% of pregnancies. Pan-prostaglandin synthesis inhibitors [nonsteroidal anti-inflammatory drugs (NSAIDs)] prevent preterm labor and prolong pregnancy but raise concerns about fetal renal and cardiovascular safety. We conducted preclinical studies examining the tocolytic effect and fetal safety of the oral prodrug candidate OBE022 [(S)-2-amino-3-methyl-butyric acid (S)-3-{[(S)-3-(biphenyl-4-sulfonyl)-thiazolidine-2-carbonyl]-amino}-3-(4-fluoro-phenyl)-propyl ester] and its parent OBE002 [(S)-3-(biphenyl-4-sulfonyl)-thiazolidine-2-carboxylic acid [(S)-1-(4-fluoro-phenyl)-3-hydroxy-propyl]-amide], both potent and highly selective antagonist of the contractile prostaglandin F2 α (PGF2 α ) receptor (FP). Efficacy of OBE022 and OBE002, alone and in combination with other tocolytics, was assessed in human tissues and pregnant animal models for inhibition of uterine contraction and delay of parturition. Selective safety of OBE022 and/or OBE002, compared with NSAID indomethacin, was assessed on renal function, closure of the ductus arteriosus, and inhibition of platelet aggregation. In in vitro studies, OBE002 inhibited spontaneous, oxytocin- and PGF2 α -induced human myometrial contractions alone and was more effective in combination with atosiban or nifedipine. In in vivo studies, OBE022 and OBE002 reduced spontaneous contractions in near-term pregnant rats. In pregnant mice, OBE022 delayed RU486 [(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one] -induced parturition and exerted synergistic effects in combination with nifedipine. OBE022 and/or OBE002 did not show the fetal side effects of ductus arteriosus constriction, impairment of kidney function, or inhibiti

JOURNAL ARTICLE

Kim SH, Binkhamis R, Cook JR, MacIntyre DA, Sykes L, Khanjani S, Bennett PR, Terzidou Vet al., 2018, A Pilot Study of Circulating miRNAs as Potential Biomarkers for Small-for-Gestational-Age Births., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 282A-282A, ISSN: 1933-7191

CONFERENCE PAPER

Kim SH, MacIntyre DA, Sykes L, Bennett PR, Terzidou Vet al., 2018, Comparing the Levels of miRNA Expression in Plasma from Blood Collected Using EDTA and Heparin Tubes, and Heparinase-Treated Plasma., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 315A-315A, ISSN: 1933-7191

CONFERENCE PAPER

Khanjani S, Islam R, Khalid J, Terzidou V, Lavery S, Hye KS, Bennett PRet al., 2018, Plasma microRNAs Identified as Novel Markers of Embryo Implantation., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 110A-110A, ISSN: 1933-7191

CONFERENCE PAPER

Brown RG, Chan D, Lee Y, Smith A, Terzidou V, MacIntyre D, Bennett Pet al., 2018, Rescue Cervical Cerclage is Associated with Good Neonatal Outcomes in Asymptomatic Women Who Are Not Colonised by Gardnerella Vaginalis., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 112A-112A, ISSN: 1933-7191

CONFERENCE PAPER

Brown RG, Marchesi JR, Lee YS, Smith A, Lehne B, Kindinger LM, Terzidou V, Holmes E, Nicholson JK, Bennett PR, MacIntyre DAet al., 2018, Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin, BMC MEDICINE, Vol: 16, ISSN: 1741-7015

JOURNAL ARTICLE

Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Mitra A, Terzidou V, Bennett P, Martin-Hirsch P, Tsilidis KK, Kyrgiou Met al., 2017, Obesity and gynaecological and obstetric conditions: umbrella review of the literature, BMJ-BRITISH MEDICAL JOURNAL, Vol: 359, ISSN: 1756-1833

JOURNAL ARTICLE

Kim SH, Bennett PR, Terzidou V, 2017, Advances in the role of oxytocin receptors in human parturition, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 449, Pages: 56-63, ISSN: 0303-7207

JOURNAL ARTICLE

Riaposova L, Kim SH, Pohl O, Chollet A, Gotteland JP, Hanyaloglu A, Bennett P, Terzidou Vet al., 2017, Combination tocolytics on the inhibition of OT-induced contractions of human pregnant myometrium in vitro, 33rd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 54-54, ISSN: 0268-1161

CONFERENCE PAPER

Kim SH, Riaposova L, Pohl O, Chollet A, Gotteland JP, Hanyaloglu A, Bennett P, Terzidou Vet al., 2017, FP receptor antagonist, OBE002, inhibits both PGF2 alpha- and OT-induced contractions of human pregnant myometrium in vitro, Publisher: OXFORD UNIV PRESS, Pages: 452-452, ISSN: 0268-1161

CONFERENCE PAPER

Cook JR, Chatfield S, Chandiramani M, Kindinger L, Cacciatore S, Sykes L, Teoh T, Shennan A, Terzidou V, Bennett PRet al., 2017, Cerclage position, cervical length and preterm delivery in women undergoing ultrasound indicated cervical cerclage: A retrospective cohort study, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Kim SH, Pohl O, Chollet A, Gotteland J-P, Fairhurst ADJ, Bennett PR, Terzidou Vet al., 2017, Differential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor-Mediated Signaling in Human Amnion and Myometrium, MOLECULAR PHARMACOLOGY, Vol: 91, Pages: 403-U201, ISSN: 0026-895X

JOURNAL ARTICLE

Vasavan T, Schultz F, Kim SH, Terzidou V, Gorelik J, Williamson Cet al., 2017, Ursodeoxycholic acid reverses the induction of calcium signalling by PGE2 in a human myometrium in vitro model of preterm labour, Publisher: WILEY, Pages: 8-8, ISSN: 1470-0328

CONFERENCE PAPER

West C, Kim SH, Khanjani S, Hanyaloglu A, Bennett P, Terzidou Vet al., 2017, Oxytocin Activates Pro-Inflammatory Pathways in Decidualised Human Endometrial Stromal Cells., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 162A-162A, ISSN: 1933-7191

CONFERENCE PAPER

Kim SH, Ahmed H, Riaposova L, Pohl O, Chollet A, Hanyaloglu A, Bennett PR, Terzidou Vet al., 2017, Both OTR Antagonists, Atosiban and Nolasiban, Inhibits PGE(2)/PGF(2 alpha)-Induced Contractions of Human Pregnant Myometrium In Vitro., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 245A-245A, ISSN: 1933-7191

CONFERENCE PAPER

Andrews V, Terzidou V, Wales N, Thomas S, Yulia A, Meritahti Met al., 2017, Positive predictors of pregnancy outcome following USS indicated and rescue cervical cerclage, Publisher: WILEY, Pages: 138-139, ISSN: 1470-0328

CONFERENCE PAPER

Andrews V, Meritahti M, Thomas S, Yulia A, Wales N, Terzidou Vet al., 2017, Ultrasound-Indicated and Rescue Cervical Cerclage and Immediate Pregnancy Outcomes: A Retrospective Observational Study., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 183A-183A, ISSN: 1933-7191

CONFERENCE PAPER

Kindinger L, MacIntyre D, Lee Y, Cook J, Terzidou V, Teoh TG, Bennett Pet al., 2016, Cervical cerclage using braided suture induces vaginal dysbiosis, inflammation and is associated with increased rates of preterm birth, Publisher: WILEY-BLACKWELL, Pages: E4-E4, ISSN: 1470-0328

CONFERENCE PAPER

Kindinger LM, Kyrgiou M, MacIntyre DA, Cacciatore S, Yulia A, Cook J, Terzidou V, Teoh TG, Bennett PRet al., 2016, Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Kindinger LM, MacIntyre DA, Lee YS, Marchesi JR, Smith A, McDonald JAK, Terzidou V, Cook JR, Lees C, Israfil-Bayli F, Faiza Y, Toozs-Hobson P, Slack M, Cacciatore S, Holmes E, Nicholson JK, Teoh TG, Bennett PRet al., 2016, Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage, SCIENCE TRANSLATIONAL MEDICINE, Vol: 8, ISSN: 1946-6234

JOURNAL ARTICLE

Cook J, MacIntyre D, Sykes L, Terzidou V, Bennett Pet al., 2016, Prediction of cervical shortening and preterm delivery using specific cell free plasma microRNAs, Publisher: WILEY-BLACKWELL, Pages: 59-60, ISSN: 1470-0328

CONFERENCE PAPER

Cook J, MacIntyre D, Kim SH, Jones B, Bennett P, Terzidou Vet al., 2016, Hsa-miR-146b-3p is functionally modulated by nuclear factor-kappa B in human myometrial cells, Publisher: WILEY-BLACKWELL, Pages: 102-102, ISSN: 1470-0328

CONFERENCE PAPER

Kindinger L, MacIntyre D, Lee Y, Marchesi J, Smith A, Terzidou V, Lees C, Teoh TG, Bennett Pet al., 2016, Cervical cerclage using braided suture induces vaginal dysbiosis, inflammation, and is associated with increased preterm birth, Publisher: WILEY-BLACKWELL, Pages: 8-8, ISSN: 1470-0328

CONFERENCE PAPER

Kim SH, Pohl O, Chollet A, Fairhurst A, Bennett P, Terzidou Vet al., 2016, The inhibition of oxytocin-driven pro-inflammatory effects in both human myometrium and amnion by the oxytocin receptor antagonist, OBE001, Publisher: WILEY-BLACKWELL, Pages: 11-12, ISSN: 1470-0328

CONFERENCE PAPER

Arulkumaran S, Kim SH, Pohl O, Chollet A, Bennett P, Terzidou Vet al., 2016, The inhibition of both spontaneous and oxytocin-induced contractions of human pregnant myometrium by the oxytocin receptor antagonist, OBE001, Publisher: WILEY-BLACKWELL, Pages: 103-104, ISSN: 1470-0328

CONFERENCE PAPER

Cook J, MacIntyre D, Sykes L, Bennett P, Terzidou Vet al., 2016, Expression of specific cell-free plasma microRNAs is associated with cervical shortening in women at risk of preterm birth, Publisher: WILEY-BLACKWELL, Pages: 103-103, ISSN: 1470-0328

CONFERENCE PAPER

Arulkumaran S, Kim SH, Pohl O, Chollet A, Bennett PR, Terzidou Vet al., 2016, The OTR Antagonist, OBE001, Inhibits Both Spontaneous and OT-Induced Contractions of Human Pregnant Myometrium In Vitro., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 299A-299A, ISSN: 1933-7191

CONFERENCE PAPER

Kim SH, Pohl O, Chollet A, Fairhurst A, Bennett PR, Terzidou Vet al., 2016, The OTR Antagonist, OBE001, Inhibits OT-Driven Proinflammatory Effects in Both Human Myometrium and Amnion, 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 123A-123A, ISSN: 1933-7191

CONFERENCE PAPER

Cook JR, MacIntyre DA, Sykes L, Terzidou V, Bennett PRet al., 2016, Prediction of Cervical Shortening and Preterm Delivery Using Specific Cell Free Plasma MicroRNAs., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 191A-192A, ISSN: 1933-7191

CONFERENCE PAPER

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