Imperial College London
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DrVanessaGarcia Larsen

Faculty of Medicine, National Heart & Lung Institute

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7945vgla

 
 
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Location

 

61Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scarpone:2023:10.1001/jamapediatrics.2023.0142,
author = {Scarpone, R and Kimkool, P and Ierodiakonou, D and Leonardi-Bee, J and Garcia-Larsen, V and Perkin, MR and Boyle, RJ},
doi = {10.1001/jamapediatrics.2023.0142},
journal = {JAMA Pediatrics},
pages = {489--497},
title = {Timing of allergenic food introduction and risk of IgE-mediated food allergy: systematic review and meta-analysis},
url = {http://dx.doi.org/10.1001/jamapediatrics.2023.0142},
volume = {177},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance  Earlier egg and peanut introduction probably reduces risk of egg and peanut allergy, respectively, but it is uncertain whether food allergy as a whole can be prevented using earlier allergenic food introduction.Objective  To investigate associations between timing of allergenic food introduction to the infant diet and risk of food allergy.Data Sources  In this systematic review and meta-analysis, Medline, Embase, and CENTRAL databases were searched for articles from database inception to December 29, 2022. Search terms included infant, randomized controlled trial, and terms for common allergenic foods and allergic outcomes.Study Selection  Randomized clinical trials evaluating age at allergenic food introduction (milk, egg, fish, shellfish, tree nuts, wheat, peanuts, and soya) during infancy and immunoglobulin E (IgE)–mediated food allergy from 1 to 5 years of age were included. Screening was conducted independently by multiple authors.Data Extraction and Synthesis  The Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline was used. Data were extracted in duplicate and synthesized using a random-effects model. The Grading of Recommendations, Assessment, Development, and Evaluation framework was used to assess certainty of evidence.Main Outcomes and Measures  Primary outcomes were risk of IgE-mediated allergy to any food from 1 to 5 years of age and withdrawal from the intervention. Secondary outcomes included allergy to specific foods.Results  Of 9283 titles screened, data were extracted from 23 eligible trials (56 articles, 13794 randomized participants). There was moderate-certainty evidence from 4 trials (3295 participants) that introduction of multiple allergenic foods from 2 to 12 months of age (median age, 3-4 months) was associated with reduced risk of food allergy (risk ratio [RR], 0.49; 95% CI, 0.33-0.74; I2 = 49%). Absolute risk difference for a population with 5% incidence of food allergy was −
AU  - Scarpone,R
AU  - Kimkool,P
AU  - Ierodiakonou,D
AU  - Leonardi-Bee,J
AU  - Garcia-Larsen,V
AU  - Perkin,MR
AU  - Boyle,RJ
DO  - 10.1001/jamapediatrics.2023.0142
EP  - 497
PY  - 2023///
SN  - 1072-4710
SP  - 489
TI  - Timing of allergenic food introduction and risk of IgE-mediated food allergy: systematic review and meta-analysis
T2  - JAMA Pediatrics
UR  - http://dx.doi.org/10.1001/jamapediatrics.2023.0142
UR  - https://jamanetwork.com/journals/jamapediatrics/fullarticle/2802512
UR  - http://hdl.handle.net/10044/1/102791
VL  - 177
ER  -
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