Imperial College London
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Vincenzo De Paola

Faculty of Medicine, Department of Brain Sciences

Reader in Translational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 2501vincenzo.depaola Website CV

 
 
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Assistant

 

Miss Lydia Lawson +44 (0)20 7594 1264

 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Calì:2018:10.1371/journal.pone.0198131,
author = {Calì, C and Wawrzyniak, M and Becker, C and Maco, B and Cantoni, M and Jorstad, A and Nigro, B and Grillo, F and De, Paola V and Fua, P and Knott, GW},
doi = {10.1371/journal.pone.0198131},
journal = {PLoS ONE},
title = {The effects of aging on neuropil structure in mouse somatosensory cortex-A 3D electron microscopy analysis of layer 1},
url = {http://dx.doi.org/10.1371/journal.pone.0198131},
volume = {13},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This study has used dense reconstructions from serial EM images to compare the neuropil ultrastructure and connectivity of aged and adult mice. The analysis used models of axons, dendrites, and their synaptic connections, reconstructed from volumes of neuropil imaged in layer 1 of the somatosensory cortex. This shows the changes to neuropil structure that accompany a general loss of synapses in a well-defined brain region. The loss of excitatory synapses was balanced by an increase in their size such that the total amount of synaptic surface, per unit length of axon, and per unit volume of neuropil, stayed the same. There was also a greater reduction of inhibitory synapses than excitatory, particularly those found on dendritic spines, resulting in an increase in the excitatory/inhibitory balance. The close correlations, that exist in young and adult neurons, between spine volume, bouton volume, synaptic size, and docked vesicle numbers are all preserved during aging. These comparisons display features that indicate a reduced plasticity of cortical circuits, with fewer, more transient, connections, but nevertheless an enhancement of the remaining connectivity that compensates for a generalized synapse loss.
AU  - Calì,C
AU  - Wawrzyniak,M
AU  - Becker,C
AU  - Maco,B
AU  - Cantoni,M
AU  - Jorstad,A
AU  - Nigro,B
AU  - Grillo,F
AU  - De,Paola V
AU  - Fua,P
AU  - Knott,GW
DO  - 10.1371/journal.pone.0198131
PY  - 2018///
SN  - 1932-6203
TI  - The effects of aging on neuropil structure in mouse somatosensory cortex-A 3D electron microscopy analysis of layer 1
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0198131
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29966021
UR  - http://hdl.handle.net/10044/1/60940
VL  - 13
ER  -
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