Imperial College London


Faculty of MedicineDepartment of Medicine

Chair in Influenza Virology



+44 (0)20 7594 5035w.barclay




416Medical SchoolSt Mary's Campus





I joined Imperial College in May 2007, moving with my research group from the University of Reading where I had previously been based since 1995.  I had graduated in Natural Sciences from Cambridge University  and had undertaken my PhD at the Common Cold Unit, Salisbury under joint supervision of Dr David Tyrrell and Dr Fred Brown, studying the human immune response to rhinovirus.  I acquired molecular virology skills as a postdoctoral fellow first in the laboratories of Professor Jeff Almond at Reading, and then working with Dr Peter Palese at the Mount Sinai School of Medicine, New York.

My expertise is in the field of respiratory viruses, in particular influenza virus. My studies aim to understand the molecular and cellular basis of the pathogenesis, host range restrictions and transmissibility of influenza viruses. The approach includes the generation of recombinant viruses with defined mutations. This strategy has contributed to the production of novel influenza pandemic vaccines. In principle the work employs the most appropriate virus strains and relevant cell or animal models. Primary influenza clinical strains are obtained through a long standing collaboration with the Health Protection Agency, and viruses are studied on primary human airway cells and in ferrets.  Translational aspects include analysing mode of action and resistance mechanisms of antiviral compounds, and characterization of novel cell substrates and attenuated virus backbones for influenza vaccines.  The laboratory is funded by MRC, BBSRC, the Wellcome Trust and commercial bodies.




Dowall SD, Bewley K, Watson RJ, et al., 2016, Antiviral Screening of Multiple Compounds against Ebola Virus, Viruses-basel, Vol:8, ISSN:1999-4915

Elderfield RA, Koutsakos M, Frise R, et al., 2016, NB protein does not affect influenza B virus replication in vitro and is not required for replication in or transmission between ferrets, Journal of General Virology, Vol:97, ISSN:0022-1317, Pages:593-601

Frise R, Bradley K, van Doremalen N, et al., 2016, Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance, Scientific Reports, Vol:6, ISSN:2045-2322

James J, Howard W, Iqbal M, et al., 2016, Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window, Journal of General Virology, Vol:97, ISSN:0022-1317, Pages:2516-2527

Kobayashi Y, Dadonaite B, van Doremalen N, et al., 2016, Computational and molecular analysis of conserved influenza A virus RNA secondary structures involved in infectious virion production, Rna Biology, Vol:13, ISSN:1547-6286, Pages:883-894

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