Imperial College London

ProfessorWendyBarclay

Faculty of MedicineDepartment of Medicine

Action Medical Research Chair in Virology
 
 
 
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Contact

 

+44 (0)20 7594 5035w.barclay

 
 
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Location

 

416Medical SchoolSt Mary's Campus

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Summary

 

Summary

I joined Imperial College in May 2007, moving with my research group from the University of Reading where I had previously been based since 1995.  I had graduated in Natural Sciences from Cambridge University  and had undertaken my PhD at the Common Cold Unit, Salisbury under joint supervision of Dr David Tyrrell and Dr Fred Brown, studying the human immune response to rhinovirus.  I acquired molecular virology skills as a postdoctoral fellow first in the laboratories of Professor Jeff Almond at Reading, and then working with Dr Peter Palese at the Mount Sinai School of Medicine, New York.

My expertise is in the field of respiratory viruses, in particular influenza virus. My studies aim to understand the molecular and cellular basis of the pathogenesis, host range restrictions and transmissibility of influenza viruses. The approach includes the generation of recombinant viruses with defined mutations. This strategy has contributed to the production of novel influenza pandemic vaccines. In principle the work employs the most appropriate virus strains and relevant cell or animal models. Primary influenza clinical strains are obtained through a long standing collaboration with the Health Protection Agency, and viruses are studied on primary human airway cells and in ferrets.  Translational aspects include analysing mode of action and resistance mechanisms of antiviral compounds, and characterization of novel cell substrates and attenuated virus backbones for influenza vaccines.  The laboratory is funded by MRC, BBSRC, the Wellcome Trust and commercial bodies.

 

Publications

Journals

Cole SL, Dunning J, Kok WL, et al., 2017, M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza, Jci Insight, Vol:2, ISSN:2379-3708

Peacock TP, Benton DJ, James J, et al., 2017, Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics, Journal of Virology, Vol:91, ISSN:0022-538X

Peacock TP, Benton DJ, Sadeyen J-R, et al., 2017, Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion, Emerging Microbes & Infections, Vol:6, ISSN:2222-1751

Singanayagam A, Zambon M, Lalvani A, et al., 2017, Urgent challenges in implementing live attenuated influenza vaccine., Lancet Infect Dis

Dowall SD, Bewley K, Watson RJ, et al., 2016, Antiviral Screening of Multiple Compounds against Ebola Virus, Viruses-basel, Vol:8, ISSN:1999-4915

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