ProfessorWaljitDhillo

Gardiner JV, Kong WM, Ward H, Murphy KG, Dhillo WS, Bloom SRet al., 2005, AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake, Biochemical and Biophysical research Communications, Vol: 327, Pages: 1088-1093

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Dhillo WS, Bloom SR, 2004, Gastrointestinal hormones and regulation of food intake, HORMONE AND METABOLIC RESEARCH, Vol: 36, Pages: 846-851, ISSN: 0018-5043

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• Citations: 39

Thompson EL, Patterson M, Murphy KG, Smith KL, Dhillo WS, Todd JF, Ghatei MA, Bloom SRet al., 2004, Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 16, Pages: 850-858, ISSN: 0953-8194

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• Citations: 387

Kong WM, Martin N, Smith K, Gardiner J, Small C, Connoley I, Stephens D, Gjatei M, Bloom Set al., 2004, Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure, Endocrinology, Vol: 145, Pages: 5252-5258

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Dhillo WS, Jeyasenna C, Jackson JE, Meeran K, Todd JFet al., 2003, Localization of gastrinomas by selective intraarterial calcium injection in patients on proton pump inhibitor or H₂-receptor antagonist therapy, ENDOCRINE-RELATED CANCER, Vol: 10, Pages: 511-512, ISSN: 1351-0088

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Dhillo WS, Jackson JE, Meeran K, Todd JFet al., 2003, A case of a metastatic insulimoma with refractory hypoglycaemia: response to embolization, ENDOCRINE-RELATED CANCER, Vol: 10, Pages: 511-511, ISSN: 1351-0088

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le Roux CW, Chapman GA, Kong WM, Dhillo WS, Jones J, Alaghband-Zadeh Jet al., 2003, Free cortisol index is better than serum total cortisol in determining hypothalamic-pituitary-adrenal status in patients undergoing surgery, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 88, Pages: 2045-2048, ISSN: 0021-972X

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• Citations: 102

Dhillo WS, Small CJ, Jethwa PH, Russell SH, Gardiner JV, Bewick GA, Seth A, Murphy KG, Ghatei MA, Bloom SRet al., 2003, Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis, ENDOCRINOLOGY, Vol: 144, Pages: 1420-1425, ISSN: 0013-7227

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• Citations: 44

Goff LM, Frost GS, Hamilton G, Thomas EL, Dhillo WS, Dornhorst A, Bell JDet al., 2003, Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids, BRITISH JOURNAL OF NUTRITION, Vol: 89, Pages: 365-374, ISSN: 0007-1145

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• Citations: 21

Kennedy AR, Todd JF, Dhillo WS, Seal LJ, Ghatei MA, O'Toole CP, Jones M, Witty D, Winborne K, Riley G, Hervieu G, Wilson S, Bloom SRet al., 2003, Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: Further evidence for a stimulatory role in the adrenal axis via SLC-1, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 15, Pages: 268-272, ISSN: 0953-8194

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• Citations: 65

Frost GS, Brynes AE, Dhillo WS, Bloom SR, McBurney MIet al., 2003, The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 57, Pages: 293-298, ISSN: 0954-3007

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• Citations: 90

Dhillo WS, Small CJ, Gardiner JV, Bewick GA, Whitworth EJ, Jethwa PH, Seal LJ, Ghatei MA, Hinson JP, Bloom SRet al., 2003, Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 301, Pages: 102-107, ISSN: 0006-291X

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• Citations: 42

Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom Set al., 2003, Effects of galanin-like Peptide on food intake and the hypothalamo-pituitary-thyroid axis, Neuroendocrinology, Vol: 77, Pages: 125-131

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Dhillo WS, Small CJ, Stanley SA, Jethwa PH, Seal LJ, Murphy KG, Ghatei MA, Bloom SRet al., 2002, Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone <i>in vitro</i> in male rats, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 14, Pages: 725-730, ISSN: 0953-8194

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• Citations: 52

Seal LJ, Small CJ, Dhillo WS, Kennedy AR, Ghatei MA, Bloom SRet al., 2002, Prolactin-releasing peptide releases corticotropin-releasing hormone and increases plasma adrenocorticotropin via the paraventricular nucleus of the hypothalamus, NEUROENDOCRINOLOGY, Vol: 76, Pages: 70-78, ISSN: 0028-3835

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• Citations: 47

le Roux CW, Sivakumaran S, Alaghband-Zadeh J, Dhillo W, Kong WM, Wheeler MJet al., 2002, Free cortisol index as a surrogate marker for serum free cortisol, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 39, Pages: 406-408, ISSN: 0004-5632

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• Citations: 76

Dhillo WS, Small CJ, Seal LJ, Kim MS, Stanley SA, Murphy KG, Ghatei MA, Bloom SRet al., 2002, The hypothalamic melanocortin system stimulates the hypothalamo-pituitary-adrenal axis in vitro and in vivo in male rats, NEUROENDOCRINOLOGY, Vol: 75, Pages: 209-216, ISSN: 0028-3835

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• Citations: 58

Taheri S, Murphy K, Cohen M, Sujkovic E, Kennedy A, Dhillo W, Dakin C, Sajedi A, Ghatei M, Bloom Set al., 2002, The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 291, Pages: 1208-1212, ISSN: 0006-291X

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• Citations: 263

Dhillo WS, Kong WM, Le Roux CW, Alaghband-Zadeh J, Jones J, Carter G, Mendoza N, Meeran K, O'Shea Det al., 2002, Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic-pituitary-adrenal axis, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 146, Pages: 231-235, ISSN: 0804-4643

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• Citations: 66

O'Shea D, Dhillo WS, 2002, Mastocytosis, Oxford Textbook of Endocrinology and Diabetes, Pages: 937-940, ISBN: 9780192630452

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Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SRet al., 2001, Ghrelin enhances appetite and increases food intake in humans, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 86, Pages: 5992-5995, ISSN: 0021-972X

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Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SRet al., 2001, Ghrelin Enhances Appetite and Increases Food Intake in Humans, The Journal of Clinical Endocrinology &amp; Metabolism, Vol: 86, Pages: 5992-5992, ISSN: 0021-972X

<jats:p>Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans. Ghrelin has been shown to promote increased food intake, weight gain and adiposity in rodents. The effect of ghrelin on appetite and food intake in man has not been determined. We investigated the effects of intravenous ghrelin (5.0 pmol/kg/min) or saline infusion on appetite and food intake in a randomised double-blind cross-over study in nine healthy volunteers. There was a clear-cut increase in energy consumed by every individual from a free-choice buffet (mean increase 28 ± 3.9%, p&amp;lt;0.001) during ghrelin compared with saline infusion. Visual analogue scores for appetite were greater during ghrelin compared to saline infusion. Ghrelin had no effect on gastric emptying as assessed by the paracetamol absorption test. Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight.</jats:p>

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Dhillo WS, Bloom SR, 2001, Hypothalamic peptides as drug targets for obesity., Curr Opin Pharmacol, Vol: 1, Pages: 651-655, ISSN: 1471-4892

The importance of the melanocortin system in obesity has been confirmed by the recent discovery of mutations in the melanocortin MC4 receptor in morbidly obese patients and the finding that intranasal administration of a fragment of melanocortin decreases body fat in humans. Transgenic mice overexpressing melanin-concentrating hormone (MCH) are obese and a second MCH receptor has been identified. In addition, ghrelin, endocannabinoids and glucagon-like peptide 2 have been identified as potentially important central regulators of food intake.

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Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SRet al., 2001, Ghrelin Causes Hyperphagia and Obesity in Rats, Diabetes, Vol: 50, Pages: 2540-2547, ISSN: 0012-1797

Ghrelin, a circulating growth hormone-releasing peptide derived from the stomach, stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was investigated and the resulting plasma ghrelin concentration was compared with that during fasting. The lowest dose of ghrelin that produced a significant stimulation of feeding after intraperitoneal injection was 1 nmol. The plasma ghrelin concentration after intraperitoneal injection of 1 nmol of ghrelin (2.83 ± 0.13 pmol/ml at 60 min postinjection) was not significantly different from that occurring after a 24-h fast (2.79 ± 0.32 pmol/ml). After microinjection into defined hypothalamic sites, ghrelin (30 pmol) stimulated food intake most markedly in the arcuate nucleus (Arc) (0-1 h food intake, 427 ± 43% of control; P < 0.001 vs. control, P < 0.01 vs. all other nuclei), which is potentially accessible to the circulation. After chronic systemic or intracerebroventricular (ICV) administration of ghrelin for 7 days, cumulative food intake was increased (intraperitoneal ghrelin 13.6 ± 3.4 g greater than saline-treated, P < 0.01; ICV ghrelin 19.6 ± 5.5 g greater than saline-treated, P < 0.05). This was associated with excess weight gain (intraperitoneal ghrelin 21.7 ± 1.4 g vs. saline 10.6 ± 1.9 g, P < 0.001; ICV ghrelin 15.3 ± 4.3 g vs. saline 2.2 ± 3.8 g, P < 0.05) and adiposity. These data provide evidence that ghrelin is important in long-term control of food intake and body weight and that circulating ghrelin at fasting concentrations may stimulate food intake.

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• Citations: 986

Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SRet al., 2001, Ghrelin causes hyperphagia and obesity in rats, DIABETES, Vol: 50, Pages: 2540-2547, ISSN: 0012-1797

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• Citations: 910

Seal LJ, Small CJ, Dhillo WS, Stanley SA, Abbott CR, Ghatei MA, Bloom SRet al., 2001, PRL-Releasing Peptide Inhibits Food Intake in Male Rats via the Dorsomedial Hypothalamic Nucleus and not the Paraventricular Hypothalamic Nucleus, Endocrinology, Vol: 142, Pages: 4236-4243, ISSN: 0013-7227

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Seal LJ, Small CJ, Dhillo WS, Stanley SA, Abbott CR, Ghatei MA, Bloom SRet al., 2001, PRL-releasing peptide inhibit food intake in male rats via the dorsomedial hypothalamic nucleus and not the paraventricular hypothalamic nucleus, ENDOCRINOLOGY, Vol: 142, Pages: 4236-4243, ISSN: 0013-7227

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• Citations: 59

Davies H, Chan NN, Dhillo WS, O'Shea Det al., 1999, Listeria meningoencephalitis masked by alcohol withdrawal, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 92, Pages: 196-197, ISSN: 0141-0768

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Davies H, Dhillo WS, Chan NN, O'Shea Det al., 1999, Listeria meningoencephalitis masked by alcohol withdrawal: a Case Report, Journal of the Royal Society of Medicine, Vol: 92, Pages: 196-197

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Comninos AN, Jayasena CN, Dhillo WS, The relationship between gut and adipose hormones, and reproduction, HUMAN REPRODUCTION UPDATE, Vol: 20, Pages: 153-174, ISSN: 1355-4786

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• Citations: 103