Publications
359 results found
Jayasena CN, Abbara A, Comninos AN, et al., 2014, Comparing the Effects of Pituitary Versus Hypothalamic Stimulation of the Human Reproductive Axis Using Equimolar Intravenous Infusions of Kisspeptin-10, Kisspeptin-54 and Gonadotrophin Releasing Hormone (GnRH) in Healthy Men, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Comninos AN, Anastasovska J, Sahuri-Arisoylu M, et al., 2014, Kisspeptin Inhibits Neuronal Activity in the Amygdala of Male Mice, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Comninos AN, Jayasena CN, Stefanopoulou E, et al., 2014, Neurokinin B Administration Induces Menopausal-like Hot Flushes in Healthy Young Women, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Abbara A, Jayasena CN, Izzi-Engbeaya C, et al., 2014, Plasma Kisspeptin Measurement during Early Pregnancy Is a Highly Predictive Marker of Subsequent Miscarriage, Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Abbara A, Jayasena CN, Comninos AN, et al., 2014, Kisspeptin - a Novel Physiological Trigger for Oocyte Maturation in IVF Treatment, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Dhillo WS, 2014, The use of functional MRI to study appetite control in the CNS, European Congress of Endocrinology
Mogford JT, Jayasena CN, Dhillo WS, 2014, Evaluating the potential utility of kisspeptin to treat reproductive disorders., Expert Rev Endocrinol Metab, Vol: 9, Pages: 251-261
The kisspeptins, encoded by the KISS1 gene, are a group of newly discovered peptides, which have been found to play an important regulatory role in human reproduction. Loss of function mutations of kisspeptin or the kisspeptin receptor have been shown to cause pubertal failure; whereas activating mutations cause precocious puberty. Central and peripheral administration of kisspeptin to mammals stimulates gonadotrophin secretion via gonadotrophin releasing hormone (GnRH) stimulation. Similar observations have been reported in human studies as well as an increase in luteinizing hormone (LH) pulsatility. Kisspeptin is now known to be associated with brain sexual differentiation, sexual dimorphism, pubertal initiation and sex steroids feedback loops, which will be discussed in this review. Metabolic state, stress, and other neuropeptides such as neurokinin B (NKB) are associated with changes in kisspeptin's stimulatory action. The conclusions from kisspeptin studies so far have led to the consideration of potential therapeutic applications, which will be discussed. Increasing our understanding of kisspeptin may aid our knowledge and management of infertility, contraception and hormone sensitive conditions.
McGowan BM, Minnion JS, Murphy KG, et al., 2014, Relaxin-3 stimulates the neuro-endocrine stress axis via corticotrophin-releasing hormone, JOURNAL OF ENDOCRINOLOGY, Vol: 221, Pages: 337-346, ISSN: 0022-0795
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- Citations: 29
Dhillo WS, 2014, Kisspeptin uncovers GnRH pulses in women with hypothalamic amenorrhea, COST meeting
Beale KE, Kinsey-Jones JS, Gardiner JV, et al., 2014, The Physiological Role of Arcuate Kisspeptin Neurons in the Control of Reproductive Function in Female Rats, ENDOCRINOLOGY, Vol: 155, Pages: 1091-1098, ISSN: 0013-7227
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- Citations: 36
Comninos A, Jayasena C, Nijher G, et al., 2014, The effects of kisspeptin administration on the menstrual cycle in healthy women, LANCET, Vol: 383, Pages: 37-37, ISSN: 0140-6736
Abbara A, Jayasena C, Comninos A, et al., 2014, Kisspeptin: a novel physiological trigger for oocyte maturation in in-vitro fertilisation treatment, LANCET, Vol: 383, Pages: 17-17, ISSN: 0140-6736
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- Citations: 7
Jayasena CN, Dhillo WS, Bloom SR, 2014, Does Kisspeptin signaling offer a new way to treat infertility?, Expert Review of Obstetrics & Gynecology, Vol: 4, Pages: 477-481, ISSN: 1747-4116
Jayasena CN, Nijher GMK, Narayanaswamy S, et al., 2014, Age-dependent elevations in plasma kisspeptin are observed in boys and girls when compared with adults, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 51, Pages: 89-96, ISSN: 0004-5632
Jayasena CN, Comninos AN, De Silva A, et al., 2014, Effects of Neurokinin B Administration on Reproductive Hormone Secretion in Healthy Men and Women, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 99, Pages: E19-E27, ISSN: 0021-972X
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- Citations: 30
Chambers ES, Viardot A, Psichas A, et al., 2014, Targeted delivery of propionate to the colon stimulates the release of anorectic gut hormones and suppresses appetite in humans, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 73, Pages: E15-E15, ISSN: 0029-6651
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- Citations: 1
Chambers ES, Viardot A, Psichas A, et al., 2014, Targeted delivery of propionate to the human colon prevents body weight and intra-abdominal adipose tissue gain in overweight adults, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 73, Pages: E22-E22, ISSN: 0029-6651
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- Citations: 1
Borsay BA, Skrapits K, Herczeg L, et al., 2014, Hypophysiotropic Gonadotropin-Releasing Hormone Projections Are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women, NEUROENDOCRINOLOGY, Vol: 100, Pages: 141-152, ISSN: 0028-3835
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- Citations: 30
Izzi-Engbeaya C, Meeran K, Dhillo WS, 2013, Kisspeptin is providing new insights into the control of reproduction, CLINICAL MEDICINE, Vol: 13, Pages: 547-548, ISSN: 1470-2118
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- Citations: 1
Jayasena CN, Comninos AN, Nijher GMK, et al., 2013, Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: 4464-4474, ISSN: 0021-972X
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- Citations: 22
Izzi-Engbeaya C, Zac-Varghese S, Palazzo F, et al., 2013, A young fit man presenting to the emergency department with a painful neck due to a thyroid abscess, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 106, Pages: 1041-1042, ISSN: 1460-2725
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- Citations: 2
Jayasena CN, Dhillo WS, 2013, Carcinoid syndrome and neuroendocrine tumours, Medicine (United Kingdom), Vol: 41, Pages: 566-569, ISSN: 1357-3039
Gut neuroendocrine tumours (NETs) arise from the gastrointestinal tract or pancreas and comprise a variety of different tumour types. Carcinoid tumours are the most common type of neuroendocrine tumour. NETs may be associated with a variety of clinical syndromes. For instance, classic symptoms of carcinoid syndrome, such as flushing and diarrhoea, occur as a consequence of the release of hormones, including serotonin, tachykinins and peptide hormones. However, the majority of NETs are not secretory in nature and are detected incidentally or through compression of surrounding structures. In the majority of cases, liver metastasis has already occurred at the time of diagnosis. However, surgery can be curative if disease is entirely localized. Somatostatin analogue injections such as octreotide are the mainstay of non-surgical treatment for NETs. Surgical debulking and embolization techniques are useful methods to reduce tumour bulk in patients who remain symptomatic despite medical treatment. Peptide receptor radionucleotide therapy using radiolabelled somatostatin analogues is becoming increasingly available. Furthermore, a number of novel agents such as everolimus have emerged in the treatment of patients with metastatic disease. This article aims to summarize the pathophysiology and clinical features of NETs, with a focus on carcinoid syndrome. It will also discuss recent advances in clinical management of NETs. © 2013 Elsevier Ltd. All rights reserved.
Jayasena CN, Comninos AN, Veldhuis JD, et al., 2013, A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women, CLINICAL ENDOCRINOLOGY, Vol: 79, Pages: 558-563, ISSN: 0300-0664
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- Citations: 37
Dhillo W, 2013, Timeline: kisspeptins, LANCET DIABETES & ENDOCRINOLOGY, Vol: 1, Pages: 12-13, ISSN: 2213-8587
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- Citations: 3
Hrabovszky E, Borsay BA, Racz K, et al., 2013, Substance P Immunoreactivity Exhibits Frequent Colocalization with Kisspeptin and Neurokinin B in the Human Infundibular Region, PLoS ONE, Vol: 8, ISSN: 1932-6203
Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion. In search of neuropeptides co-expressed in analogous neurons of the human infundibular nucleus (Inf), we have carried out immunohistochemical studies of the tachykinin peptide Substance P (SP) in autopsy samples from men (21-78 years) and postmenopausal (53-83 years) women. Significantly higher numbers of SP-immunoreactive (IR) neurons and darker labeling were observed in the Inf of postmenopausal women than in age-matched men. Triple-immunofluorescent studies localized SP immunoreactivity to considerable subsets of KP-IR and NKB-IR axons and perikarya in the infundibular region. In postmenopausal women, 25.1% of NKB-IR and 30.6% of KP-IR perikarya contained SP and 16.5% of all immunolabeled cell bodies were triple-labeled. Triple-, double- and single-labeled SP-IR axons innervated densely the portal capillaries of the infundibular stalk. In quadruple-labeled sections, these axons formed occasional contacts with GnRH-IR axons. Presence of SP in NKB and KP neurons increases the functional complexity of the putative pulse generator network. First, it is possible that SP modulates the effects of KP and NKB in axo-somatic and axo-dendritic afferents to GnRH neurons. Intrinsic SP may also affect the activity and/or neuropeptide release of NKB and KP neurons via autocrine/paracrine actions. In the infundibular stalk, SP may influence the KP and NKB secretory output via additional autocrine/paracrine mechanisms or regulate GnRH neurosecretion directly. Finally, possible co-release of SP with KP and NKB into the portal circulation could underlie further actions on adenohypophysial gonadotrophs.
van der Klaauw AA, Keogh JM, Henning E, et al., 2013, High Protein Intake Stimulates Postprandial GLP1 and PYY Release, OBESITY, Vol: 21, Pages: 1602-1607, ISSN: 1930-7381
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- Citations: 95
Jayasena CN, Abbara A, Comninos AN, et al., 2013, Kisspeptin-54 administration stimulates pulsatile luteinising hormone secretion in women with hypothalamic amenorrhea, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 110-110, ISSN: 0268-1161
Jayasena CN, Modi M, Palazzo F, et al., 2013, Associations of serum 25-hydroxyvitamin D with circulating PTH, phosphate and calcium in patients with primary hyperparathyroidism, CLINICAL ENDOCRINOLOGY, Vol: 78, Pages: 838-843, ISSN: 0300-0664
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- Citations: 8
Comninos AN, Jayasena CN, Nijher GMK, et al., 2013, Chronic kisspeptin administration advances the menstrual cycle in healthy women, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 334-335, ISSN: 0268-1161
Ratnasabapathy R, Dhillo WS, 2013, The Effects of Kisspeptin in Human Reproductive Function - Therapeutic Implications, CURRENT DRUG TARGETS, Vol: 14, Pages: 365-371, ISSN: 1389-4501
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- Citations: 21
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