Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mills:2018:10.1530/JOE-18-0269,
author = {Mills, EG and Dhillo, WS and Comninos, AN},
doi = {10.1530/JOE-18-0269},
journal = {Journal of Endocrinology},
pages = {R1--R12},
title = {Kisspeptin and the control of emotions, mood and reproductive behaviour},
url = {http://dx.doi.org/10.1530/JOE-18-0269},
volume = {239},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Reproduction is fundamental for the survival of all species and requires meticulous synchronisation of a diverse complement of neural, endocrine and related behaviours. The reproductive hormone kisspeptin (encoded by the KISS1/kiss1 gene), is now a well-established orchestrator of reproductive hormones, acting upstream of gonadotrophin releasing hormone (GnRH) at the apex of the hypothalamic-pituitary-gonadal (HPG) reproductive axis. Beyond the hypothalamus, kisspeptin is also expressed in limbic and paralimbic brain regions, which are areas of the neurobiological network implicated in sexual and emotional behaviours. We are now forming a more comprehensive appreciation of extra-hypothalamic kisspeptin signalling and the complex role of kisspeptin as an upstream mediator of reproductive behaviours, including olfactory-driven partner preference, copulatory behaviour, audition, mood and emotion. An increasing body of research from zebrafish to humans has implicated kisspeptin in the integration of reproductive hormones with an overall positive influence on these reproductive behaviours. In this review, we critically appraise the current literature regarding kisspeptin and its control of reproductive behaviour. Collectively, these data significantly enhance our understanding of the integration of reproductive hormones and behaviour and provide the foundation for kisspeptin-based therapies to treat related disorders of body and mind.
AU  - Mills,EG
AU  - Dhillo,WS
AU  - Comninos,AN
DO  - 10.1530/JOE-18-0269
EP  - 12
PY  - 2018///
SN  - 1479-6805
SP  - 1
TI  - Kisspeptin and the control of emotions, mood and reproductive behaviour
T2  - Journal of Endocrinology
UR  - http://dx.doi.org/10.1530/JOE-18-0269
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29967050
UR  - https://joe.bioscientifica.com/view/journals/joe/239/1/JOE-18-0269.xml
UR  - http://hdl.handle.net/10044/1/62022
VL  - 239
ER  -
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