Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Milona:2019:10.1016/j.molmet.2019.09.007,
author = {Milona, A and Massafra, V and Vos, H and Naik, J and Artigas, N and Paterson, HAB and Bijsmans, ITGW and Willemsen, ECL and Ramos, Pittol JM and Miguel-Aliaga, I and Bosma, P and Burgering, BMT and Williamson, C and Vernia, S and Dhillo, WS and van, Mil SWC and Owen, BM},
doi = {10.1016/j.molmet.2019.09.007},
journal = {Molecular Metabolism},
pages = {221--229},
title = {Steroidogenic control of liver metabolism through a nuclear receptor-network},
url = {http://dx.doi.org/10.1016/j.molmet.2019.09.007},
volume = {30},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic tissues are largely unknown. METHODS AND RESULTS: Here, we show that in the liver, the classical steroidogenic enzyme Cyp17a1 forms an essential nexus for glucose and ketone metabolism during feed-fast cycles. Both gain- and loss-of-function approaches are used to show that hepatic Cyp17a1 is induced by fasting, catalyzes the production of at least one hormone-ligand (DHEA) for the nuclear receptor PPARα, and is ultimately required for maintaining euglycemia and ketogenesis during nutrient deprivation. The feedback-loop that terminates Cyp17a1-PPARα activity, and re-establishes anabolic liver metabolism during re-feeding is mapped to postprandial bile acid-signaling, involving the receptors FXR, SHP and LRH-1. CONCLUSIONS: Together, these findings represent a novel paradigm of homeostatic control in which nutritional cues feed-forward on to metabolic pathways by influencing extragonadal steroidogenesis.
AU  - Milona,A
AU  - Massafra,V
AU  - Vos,H
AU  - Naik,J
AU  - Artigas,N
AU  - Paterson,HAB
AU  - Bijsmans,ITGW
AU  - Willemsen,ECL
AU  - Ramos,Pittol JM
AU  - Miguel-Aliaga,I
AU  - Bosma,P
AU  - Burgering,BMT
AU  - Williamson,C
AU  - Vernia,S
AU  - Dhillo,WS
AU  - van,Mil SWC
AU  - Owen,BM
DO  - 10.1016/j.molmet.2019.09.007
EP  - 229
PY  - 2019///
SN  - 2212-8778
SP  - 221
TI  - Steroidogenic control of liver metabolism through a nuclear receptor-network
T2  - Molecular Metabolism
UR  - http://dx.doi.org/10.1016/j.molmet.2019.09.007
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31767173
UR  - http://hdl.handle.net/10044/1/75365
VL  - 30
ER  -
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