Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Izzi-Engbeaya:2020:clinem/dgaa072,
author = {Izzi-Engbeaya, C and Dhillo, W and Tan, T and Abbara, A and Comninos, A and Bech, P and Minnion, J},
doi = {clinem/dgaa072},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {1--7},
title = {Effects of glucagon-like peptide-1 on the reproductive axis in healthy men},
url = {http://dx.doi.org/10.1210/clinem/dgaa072},
volume = {105},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ContextGlucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans.ObjectiveTo investigate the effects of GLP-1 administration on the reproductive axis in humans.DesignSingle-blind, randomized, placebo-controlled crossover study.SettingClinical Research Facility, Imperial College Healthcare NHS Trust.ParticipantsEighteen healthy men (mean age 24.7 ± 0.1years, mean BMI 22.1 ± 0.4kg/m2).InterventionEight-hour intravenous infusion of 0.8 pmol/kg/min GLP-1 or rate-matched vehicle infusion.Main Outcome MeasuresNumber of luteinizing hormone (LH) pulses, LH, follicle-stimulating hormone (FSH), and testosterone levels.ResultsThe number of LH pulses (number of LH pulses/500 min: vehicle 4.2 ± 0.4, GLP-1 4.5 ± 0.3, P = 0.46), LH area under the curve (AUC) (vehicle 1518 ± 88min.IU/L, GLP-1 1524 ± 101min.IU/L, P = 0.95), follicle-stimulating hormone AUC (vehicle 1210 ± 112 min IU/L, GLP-1 1216 ± 112 min IU/L, P = 0.86), and testosterone AUC (vehicle 10893 ± 615 min nmol/L, GLP-1 11088 ± 792 min nmol/L, P = 0.77) did not significantly differ during vehicle and GLP-1 administration. Glucagon-like peptide-1 significantly reduced food intake (vehicle 15.7 ± 1.3 kcal/kg, GLP-1 13.4 ± 1.3 kcal/kg, P = 0.01).ConclusionsIn contrast to the animal literature, our data demonstrate that acute GLP-1 administration does not affect reproductive hormone secretion in healthy men.
AU  - Izzi-Engbeaya,C
AU  - Dhillo,W
AU  - Tan,T
AU  - Abbara,A
AU  - Comninos,A
AU  - Bech,P
AU  - Minnion,J
DO  - clinem/dgaa072
EP  - 7
PY  - 2020///
SN  - 0021-972X
SP  - 1
TI  - Effects of glucagon-like peptide-1 on the reproductive axis in healthy men
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/clinem/dgaa072
UR  - https://academic.oup.com/jcem/article/105/4/dgaa072/5735220
UR  - http://hdl.handle.net/10044/1/77679
VL  - 105
ER  -
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