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@article{Chambers:2015:10.1136/gutjnl-2014-307913,
author = {Chambers, ES and Viardot, A and Psichas, A and Morrison, DJ and Murphy, KG and Zac-Varghese, SEK and MacDougall, K and Preston, T and Tedford, C and Finlayson, GS and Blundell, JE and Bell, JD and Thomas, EL and Mt-Isa, S and Ashby, D and Gibson, GR and Kolida, S and Dhillo, WS and Bloom, SR and Morley, W and Clegg, S and Frost, G},
doi = {10.1136/gutjnl-2014-307913},
journal = {Gut},
pages = {1744--1754},
title = {Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults},
url = {http://dx.doi.org/10.1136/gutjnl-2014-307913},
volume = {64},
year = {2015}
}

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TY  - JOUR
AB  - Objective The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in overweight adults.Design To investigate whether propionate promotes PYY and GLP-1 secretion, a primary cultured human colonic cell model was developed. To deliver propionate specifically to the colon, we developed a novel inulin-propionate ester. An acute randomised, controlled cross-over study was used to assess the effects of this inulin-propionate ester on energy intake and plasma PYY and GLP-1 concentrations. The long-term effects of inulin-propionate ester on weight gain were subsequently assessed in a randomised, controlled 24-week study involving 60 overweight adults.Results Propionate significantly stimulated the release of PYY and GLP-1 from human colonic cells. Acute ingestion of 10g inulin-propionate ester significantly increased postprandial plasma PYY and GLP-1 and reduced energy intake. Over 24weeks, 10g/day inulin-propionate ester supplementation significantly reduced weight gain, intra-abdominal adipose tissue distribution, intrahepatocellular lipid content and prevented the deterioration in insulin sensitivity observed in the inulin-control group.Conclusions These data demonstrate for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.
AU  - Chambers,ES
AU  - Viardot,A
AU  - Psichas,A
AU  - Morrison,DJ
AU  - Murphy,KG
AU  - Zac-Varghese,SEK
AU  - MacDougall,K
AU  - Preston,T
AU  - Tedford,C
AU  - Finlayson,GS
AU  - Blundell,JE
AU  - Bell,JD
AU  - Thomas,EL
AU  - Mt-Isa,S
AU  - Ashby,D
AU  - Gibson,GR
AU  - Kolida,S
AU  - Dhillo,WS
AU  - Bloom,SR
AU  - Morley,W
AU  - Clegg,S
AU  - Frost,G
DO  - 10.1136/gutjnl-2014-307913
EP  - 1754
PY  - 2015///
SN  - 0017-5749
SP  - 1744
TI  - Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
T2  - Gut
UR  - http://dx.doi.org/10.1136/gutjnl-2014-307913
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362593700011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://gut.bmj.com/content/64/11/1744
UR  - http://hdl.handle.net/10044/1/21495
VL  - 64
ER  -

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