Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clarke:2015:10.3803/EnM.2015.30.2.124,
author = {Clarke, H and Dhillo, WS and Jayasena, CN},
doi = {10.3803/EnM.2015.30.2.124},
journal = {Endocrinology and Metabolism},
pages = {124--141},
title = {Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders},
url = {http://dx.doi.org/10.3803/EnM.2015.30.2.124},
volume = {30},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling causes hypogonadotrophic hypogonadism in humans and other mammals. Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation. In addition, a growing body of evidence suggests that kisspeptin signaling be regulated by nutritional status and stress. Kisspeptin may also represent a novel potential therapeutic target in the treatment of fertility disorders. Early human studies suggest that peripheral exogenous kisspeptin administration stimulates gonadotrophin release in healthy adults and in patients with certain forms of infertility. This review aims to concisely summarize what is known about kisspeptin as a regulator of reproductive function, and provide an update on recent advances within this field.
AU  - Clarke,H
AU  - Dhillo,WS
AU  - Jayasena,CN
DO  - 10.3803/EnM.2015.30.2.124
EP  - 141
PY  - 2015///
SN  - 2093-5978
SP  - 124
TI  - Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
T2  - Endocrinology and Metabolism
UR  - http://dx.doi.org/10.3803/EnM.2015.30.2.124
UR  - http://hdl.handle.net/10044/1/34480
VL  - 30
ER  -
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