Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Katugampola:2017:10.1210/jc.2017-00763,
author = {Katugampola, H and King, PJ and Chatterjee, S and Meso, M and Duncan, AJ and Achermann, JC and Guasti, L and Ghataore, L and Taylor, NF and Allen, R and Marlene, S and Aquilina, J and Abbara, A and Jaysena, CN and Dhillo, WS and Dunkel, L and Sankilampi, U and Storr, HL},
doi = {10.1210/jc.2017-00763},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {3349--3359},
title = {Kisspeptin Is a Novel Regulator of Human Fetal Adrenocortical Development and Function: A Finding With Important Implications for the Human Fetoplacental Unit},
url = {http://dx.doi.org/10.1210/jc.2017-00763},
volume = {102},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ContextThe human fetal adrenal (HFA) is an integral component of the fetoplacental unit and important for the maintenance of pregnancy. Low kisspeptin levels during pregnancy are associated with miscarriage, and kisspeptin and its receptor are expressed in the HFA. However, the role of kisspeptin in fetal adrenal function remains unknown.ObjectiveTo determine the role of kisspeptin in the developing HFA.DesignExperiments using H295R and primary HFA cells as in vitro models of the fetal adrenal. Association of plasma kisspeptin levels with HFA size in a longitudinal clinical study.SettingAcademic research center and tertiary fetal medicine unit.ParticipantsThirty-three healthy pregnant women were recruited at their 12-week routine antenatal ultrasound scan.Main Outcome MeasuresThe spatiotemporal expression of Kiss1R in the HFA. The production of dehydroepiandrosterone sulfate (DHEAS) from HFA cells after kisspeptin treatment, alone or in combination with adrenocorticotropic hormone or corticotropin-releasing hormone. Fetal adrenal volume (FAV) and kisspeptin levels at four antenatal visits (∼20, 28, 34, and 38 weeks’ gestation).ResultsExpression of Kiss1R was present in the HFA from 8 weeks after conception to term and was shown in the inner fetal zone. Kisspeptin significantly increased DHEAS production in H295R and second-trimester HFA cells. Serial measurements of kisspeptin confirmed a correlation with FAV growth in the second trimester, independent of sex or estimated fetal weight.ConclusionsKisspeptin plays a key role in the regulation of the HFA and thus the fetoplacental unit, particularly in the second trimester of pregnancy.
AU  - Katugampola,H
AU  - King,PJ
AU  - Chatterjee,S
AU  - Meso,M
AU  - Duncan,AJ
AU  - Achermann,JC
AU  - Guasti,L
AU  - Ghataore,L
AU  - Taylor,NF
AU  - Allen,R
AU  - Marlene,S
AU  - Aquilina,J
AU  - Abbara,A
AU  - Jaysena,CN
AU  - Dhillo,WS
AU  - Dunkel,L
AU  - Sankilampi,U
AU  - Storr,HL
DO  - 10.1210/jc.2017-00763
EP  - 3359
PY  - 2017///
SN  - 0021-972X
SP  - 3349
TI  - Kisspeptin Is a Novel Regulator of Human Fetal Adrenocortical Development and Function: A Finding With Important Implications for the Human Fetoplacental Unit
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/jc.2017-00763
UR  - http://hdl.handle.net/10044/1/54187
VL  - 102
ER  -
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