Imperial College London
Alternate

Dr Warren Macdonald

Faculty of Engineering, Department of Bioengineering

Senior Teaching Fellow
 
 
 
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Contact

 

+44 (0)20 7594 6372w.macdonald

 
 
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Location

 

B 3.25Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carlsson:2006,
author = {Carlsson, LV and Albrektsson, BE and Albrektsson, BG and Albrektsson, TO and Jacobsson, CM and Macdonald, W and Regner, L and Rostlund, T and Weidenhielm, LR},
journal = {Acta Orthop},
pages = {549--558},
title = {Stepwise introduction of a bone-conserving osseointegrated hip arthroplasty using RSA and a randomized study: I. Preliminary investigations--52 patients followed for 3 years},
volume = {77},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: We developed a total hip system using osseointegration guidelines, a metaphyseal-loading proximal femoral replacement in the retained neck and a dual-geometry titanium shell in the acetabulum. PATIENTS AND METHODS: A randomized controlled clinical trial was undertaken in 52 patients (53 hips), using the cemented Spectron stem and cementless Harris-Galante II cup as control implants (24 patients in experimental group, 29 control patients). Clinical measures of Harris Hip Score (HHS), pain score and radiostereometric analysis (RSA) at regular intervals for up to three years were used to monitor progress. RESULTS: No statistically significant differences were found in HHS and pain score; the stability of the cementless experimental implant was also comparable to that of the cemented controls by RSA. 3 revisions were required for migration in the experimental group and 1 was required for component dislocation in the control group. INTERPRETATION: Our findings indicate the practicality of osseointegration of titanium implants, but suggest that current performance is inadequate for clinical introduction. However, the stable fixation achieved in the retained neck in the majority of patients is indicative of osseointegration. This finding will encourage technical and design improvements for enhancement of clinical osseointegration and should also encourage further study. Periprosthetic osteolysis might be avoided by the establishment and maintenance of direct implant-bone connection: "osseointegration".
AU  - Carlsson,LV
AU  - Albrektsson,BE
AU  - Albrektsson,BG
AU  - Albrektsson,TO
AU  - Jacobsson,CM
AU  - Macdonald,W
AU  - Regner,L
AU  - Rostlund,T
AU  - Weidenhielm,LR
EP  - 558
PY  - 2006///
SP  - 549
TI  - Stepwise introduction of a bone-conserving osseointegrated hip arthroplasty using RSA and a randomized study: I. Preliminary investigations--52 patients followed for 3 years
T2  - Acta Orthop
VL  - 77
ER  -
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