Imperial College London

DrWilliamMan

Faculty of MedicineNational Heart & Lung Institute

Reader in Respiratory Medicine
 
 
 
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Contact

 

+44 (0)1895 828 851w.man

 
 
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Location

 

Harefield HospitalHarefield Hospital

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Summary

 

Publications

Publication Type
Year
to

297 results found

Amanda Natanek S, Riddoch-Contreras J, Sarah Marsh G, Stephen Hopkinson N, Man WD-C, Moxham J, Iain Polkey M, Robert Kemp Pet al., 2011, Yin Yang 1 expression and localisation in quadriceps muscle in COPD, ARCHIVOS DE BRONCONEUMOLOGIA, Vol: 47, Pages: 296-302, ISSN: 0300-2896

Journal article

Dodd JW, Hogg L, Nolan J, Jefford H, Grant A, Lord VM, Falzon C, Garrod R, Lee C, Polkey MI, Jones PW, Man WD-C, Hopkinson NSet al., 2011, The COPD assessment test (CAT): response to pulmonary rehabilitation. A multicentre, prospective study, THORAX, Vol: 66, Pages: 425-429, ISSN: 0040-6376

Journal article

Man WD-C, Grant A, Hogg L, Moore J, Barker RD, Moxham Jet al., 2011, Pulmonary rehabilitation in patients with MRC Dyspnoea Scale 2, THORAX, Vol: 66, Pages: 263-263, ISSN: 0040-6376

Journal article

Waschki B, Spruit MA, Watz H, Albert P, Shrikrishnapalasuriyar D, Smith C, Man WD-C, Tal-Singer R, Edwards L, Calverley PM, Magnussen H, Polkey MI, Wouters EFMet al., 2011, Measurement Of Physical Activity In Patients With COPD In A Multicenter Setting: Compliance And Associations With Clinical Characteristics Of The Disease, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Dodd JW, Hogg L, Nolan J, Jefford H, Grant A, Lord V, Falzon C, Garrod R, Lee C, Polkey MI, Jones P, Man WD-C, Hopkinson NSet al., 2011, The COPD Assessment Test (CAT) - Response To Pulmonary Rehabilitation. A Multicentre, Prospective Study, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Natanek SA, Gosker HR, Slot I, Marsh GS, Langen RCJ, Hopkinson NS, Man WD-C, Moxham J, Kemp PR, Schols AMWJ, Polkey MIet al., 2010, MUSCLE FIBRE ATROPHY AND AEROBIC TO ANAEROBIC FIBRE TYPE SHIFT IN THE QUADRICEPS IN COPD, Publisher: B M J PUBLISHING GROUP, Pages: A139-A139, ISSN: 0040-6376

Conference paper

Ingram KA, Fowler RP, Clark AL, Nolan CM, Man WDet al., 2010, THE EFFECT OF CO-MORBIDITIES ON RESPONSE TO PULMONARY REHABILITATION, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A99-A100, ISSN: 0040-6376

Conference paper

Nolan CM, Ingram KA, Fowler RP, Clark AL, Man WDet al., 2010, ATTENDANCE RATES AND RESPONSE TO PULMONARY REHABILITATION, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A97-A97, ISSN: 0040-6376

Conference paper

Fowler RP, Ingram KA, Clark AL, Nolan CM, Man WDet al., 2010, DO CHANGES IN OBJECTIVE OUTCOME MEASURES MATCH PATIENT-REPORTED EXPERIENCE OF PULMONARY REHABILITATION?, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A95-A95, ISSN: 0040-6376

Conference paper

Donaldson AV, Garfield BE, Patel MS, Clark AL, Polkey MI, Man WDet al., 2010, 4-METRE GAIT SPEED AS A FUNCTIONAL OUTCOME MEASURE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD), British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A34-A35, ISSN: 0040-6376

Conference paper

Natanek SA, Langen RCJ, Gosker HR, Marsh GS, Slot I, Hopkinson NS, Man WD-C, Kemp PR, Moxham J, Schols AMWJ, Polkey MIet al., 2010, NF-KAPPA B (NF-κB) AND ACTIVATOR PROTEIN-1 (AP-1) DNA BINDING IN THE QUADRICEPS OF COPD PATIENTS, Publisher: B M J PUBLISHING GROUP, Pages: A138-A139, ISSN: 0040-6376

Conference paper

Patel MS, Clark AL, Ingram KA, Fowler RP, Donaldson AV, Kon SS, Polkey MI, Man WDet al., 2010, EFFECT OF PULMONARY REHABILITATION ON THE SHORT PHYSICAL PERFORMANCE BATTERY (SPPB) IN COD, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A35-A35, ISSN: 0040-6376

Conference paper

Dodd JW, Hogg L, Nolan J, Jefford H, Lord VM, Garrod R, Polkey MI, Jones PW, Man WD-C, Hopkinson NSet al., 2010, THE COPD ASSESSMENT TEST SCORE (CAT): A MULTICENTRE, PROSPECTIVE STUDY OF RESPONSE TO PULMONARY REHABILITATION, British-Thoracic-Society-Winter-Meeting 2010, Publisher: BMJ PUBLISHING GROUP, Pages: A36-A36, ISSN: 0040-6376

Conference paper

Man W-C, Natanek SA, Riddoch-Contreras J, Lewis A, Marsh GS, Kemp PR, Polkey MIet al., 2010, Quadriceps myostatin expression in COPD, European Respiratory Journal, Vol: 36, Pages: 686-688

Journal article

Seymour JM, Moore L, Jolley CJ, Ward K, Creasey J, Steier JS, Yung B, Man WD-C, Hart N, Polkey MI, Moxham Jet al., 2010, Outpatient pulmonary rehabilitation following acute exacerbations of COPD, THORAX, Vol: 65, Pages: 423-428, ISSN: 0040-6376

Journal article

Lewis A, Sathyapala SA, Riddoch-Contreras J, Man WDC, Marsh GS, Polkey MI, Hopkinson NS, Kemp PRet al., 2009, REDUCED EXPRESSION AND ACTIVITY OF MYOCARDIN-RELATED TRANSCRIPTION FACTORS CONTRIBUTES TO FIBRE TYPE CHANGES IN THE QUADRICEPS OF PATIENTS WITH COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A134-A134, ISSN: 0040-6376

Conference paper

Man WD, Sathyapala SA, Riddoch-Contreras J, Lewis A, Marsh G, Polkey MI, Kemp PRet al., 2009, QUADRICEPS MUSCLE EXPRESSION OF MYOSTATIN IN PATIENTS WITH COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A39-A39, ISSN: 0040-6376

Conference paper

Seymour J, Sathyapala SA, Jackson AS, Hopkinson NS, Moxham Jet al., 2009, The prevalence of quadriceps weakness in COPD and the relationship with disease severity, European Respiratory Journal

Journal article

Man WD-C, Kemp P, Moxham J, Polkey MIet al., 2009, Exercise and muscle dysfunction in COPD: implications for pulmonary rehabilitation, CLINICAL SCIENCE, Vol: 117, Pages: 281-291, ISSN: 0143-5221

Journal article

Seymour JM, Spruit MA, Hopkinson NS, Sathyapala A, Man WD-C, Jackson A, Gosker HR, Schols AMWJ, Moxham J, Polkey MI, Wouters EFMet al., 2009, The Prevalence of Quadriceps Weakness in COPD and the Relationship with Disease Severity, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X

Journal article

Man WD, Kemp P, Moxham J, Polkey MIet al., 2009, Skeletal muscle dysfunction in COPD: clinical and laboratory observations, Clinical Science (Lond), Vol: 117, Pages: 251-264

COPD (chronic obstructive pulmonary disease), although primarily a disease of the lungs, exhibits secondary systemic manifestations. The skeletal muscles are of particular interest because their function (or dysfunction) not only influences the symptoms that limit exercise, but may contribute directly to poor exercise performance. Furthermore, skeletal muscle weakness is of great clinical importance in COPD as it is recognized to contribute independently to poor health status, increased healthcare utilization and even mortality. The present review describes the current knowledge of the structural and functional abnormalities of skeletal muscles in COPD and the possible aetiological factors. Increasing knowledge of the molecular pathways of muscle wasting will lead to the development of new therapeutic agents and strategies to combat COPD muscle dysfunction.

Journal article

Harraf F, Ward K, Man W, Rafferty G, Mills K, Polkey M, Moxham J, Kalra Let al., 2008, Transcranial magnetic stimulation study of expiratory muscle weakness in acute ischemic stroke, NEUROLOGY, Vol: 71, Pages: 2000-2007, ISSN: 0028-3878

Journal article

Man WD-C, Steier J, Hopkinson NS, Luo Y-M, Jolley CJ, Mustfa N, Harraf F, Nikoletou D, Rafferty GF, Polkey MI, Moxham Jet al., 2008, SNIFF AND TWITCH TRANSDIAPHRAGMATIC PRESSURES IN HEALTH AND DISEASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A31-A32, ISSN: 0040-6376

Conference paper

Moore L, Moore J, Grant A, Man WD-C, Seymour J, Jolley CJ, Polkey MI, Gray BJ, Barker RD, Moxham Jet al., 2008, DOES SEASONAL VARIATION INFLUENCE THE EFFICACY OF PULMONARY REHABILITATION?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A94-A94, ISSN: 0040-6376

Conference paper

Seymour JM, Hopkinson N, Jackson A, Man WD-C, Harris M-L, Sathyapala SA, Spruit MA, Wouters EFM, Moxham J, Polkey MIet al., 2008, REDUCED QUADRICEPS STRENGTH IN EX-SMOKERS WITHOUT CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A17-A18, ISSN: 0040-6376

Conference paper

Moore J, Grant A, Moore L, Man WD-C, Seymour J, Jolley CJ, Polkey MI, Gray BJ, Barker RD, Moxham Jet al., 2008, COMMUNITY PULMONARY REHABILITATION IN OCTOGENARIANS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A93-A93, ISSN: 0040-6376

Conference paper

Grant A, Moore J, Moore L, Man WD-C, Seymour J, Jolley CJ, Polkey MI, Gray BJ, Barker RD, Moxham Jet al., 2008, IS SUPERVISED COMMUNITY-BASED PULMONARY REHABILITATION EFFECTIVE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A95-A96, ISSN: 0040-6376

Conference paper

Bonnici KS, Man WD-C, Polkey MI, 2008, Acute respiratory distress in a patient using non-invasive ventilation., Thorax, Vol: 63, Pages: 802-844

Journal article

Alty SR, Man WDC, Moxham J, Lee KCet al., 2008, Denoising of diaphragmatic electromyogram signals for respiratory control and diagnostic purposes, Pages: 5560-5563

Diaphragmatic electromyogram (EMGdi) signals give important information about the respiratory muscle pump, can be used as an indicator of neural respiratory drive, and have been postulated as a method of designing neurally-activated intelligent ventilators. However diaphragmatic EMG signals measured with an esophageal catheter tend to be contaminated by electrical signals from the heart - electrocardiogram (ECG). This paper presents a novel method of rapidly separating and enhancing the Electromyogram signals from the combined EMG and ECG signals recorded from an esophageal catheter based sensor. Independent Component Analysis (ICA) is used to separate the EMG and ECG signals, then further processing is used to extract the frequency of the patient's breathing and the relative magnitudes of diaphragmatic muscle activity. These signals have two applications, firstly in artificial ventilator systems and as a diagnostic tool for health professionals. © 2008 IEEE.

Conference paper

Alty SR, Man WD-C, Moxham J, Lee KCet al., 2008, Denoising of Diaphragmatic Electromyogram Signals for Respiratory Control and Diagnostic Purposes, 2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8, Pages: 5560-+, ISSN: 1557-170X

Journal article

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