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@article{Nolan:2018:10.1183/13993003.01186-2018,
author = {Nolan, CM and Maddocks, M and Maher, TM and Banya, W and Patel, S and Barker, RE and Jones, SE and George, P and Cullinan, P and Man, WD-C},
doi = {10.1183/13993003.01186-2018},
journal = {European Respiratory Journal},
pages = {1--10},
title = {Gait speed and prognosis in patients with idiopathic pulmonary fibrosis: a prospective cohort study},
url = {http://dx.doi.org/10.1183/13993003.01186-2018},
volume = {53},
year = {2018}
}

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TY  - JOUR
AB  - The four metre gait speed (4MGS), a simple physical performance measure and surrogate marker of frailty, consistently predicts adverse prognosis in older adults. We hypothesised that 4MGS could predict all-cause mortality and non-elective hospitalisation in patients with idiopathic pulmonary fibrosis (IPF).4MGS and lung function were measured at baseline in 130 outpatients newly diagnosed with IPF. Survival status and non-elective hospital admissions were recorded over one year. We assessed the predictive value of 4MGS (as a continuous variable and as a binary variable: slow versus preserved 4MGS) by calculating hazard ratios (HR) using Cox proportional regression, adjusting for potential confounding variables. Receiver Operating Characteristic curves assessed discrimination between the multivariable regression models and established prognostic indices.Continuous 4MGS and slow 4MGS were independent predictors of all-cause mortality (4MGS: HR 0.03 (0.01-0.31), p=0.004; slow 4MGS: 2.63 (1.01-6.87), p=0.049) and hospitalisation (4MGS: HR 0.02 (0.01-0.14), p<0.001; slow 4MGS: 2.76 (1.16-6.58), p=0.02). Multivariable models incorporating 4MGS or slow 4MGS had better discrimination for predicting mortality than either the Gender Age Physiology index or Composite Physiologic Index.In patients with IPF, 4MGS is an independent predictor of all-cause mortality and non-elective hospitalisation.
AU  - Nolan,CM
AU  - Maddocks,M
AU  - Maher,TM
AU  - Banya,W
AU  - Patel,S
AU  - Barker,RE
AU  - Jones,SE
AU  - George,P
AU  - Cullinan,P
AU  - Man,WD-C
DO  - 10.1183/13993003.01186-2018
EP  - 10
PY  - 2018///
SN  - 0903-1936
SP  - 1
TI  - Gait speed and prognosis in patients with idiopathic pulmonary fibrosis: a prospective cohort study
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.01186-2018
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30487200
UR  - https://erj.ersjournals.com/content/53/2/1801186
UR  - http://hdl.handle.net/10044/1/64866
VL  - 53
ER  -

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