Prof. William Wisden F. Med. Sci.

Osten P, Wisden W, Sprengel R, 2007, Molecular mechanisms of synaptic function in the hippocampus: neurotransmitter exocytosis, glutamatergic, GABAergic and cholinergic transmission., The hippocampus book, Editors: Andersen, Morris, Amaral, Bliss, O'Keefe, Publisher: Oxford University Press, USA, Pages: 243-295, ISBN: 9780195100273

The Hippocampus Book is destined to take a central place on every neuroscientist'sbookshelf.

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Goetz T, Arslan A, Wisden W, Wulff Pet al., 2007, GABA_A receptors:: structure and function in the basal ganglia, GABA AND THE BASAL GANGLIA: FROM MOLECULES TO SYSTEMS, Vol: 160, Pages: 21-41, ISSN: 0079-6123

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• Citations: 83

Linden AM, Aller MI, Leppä E, Vekovischeva O, Aitta-Aho T, Veale EL, Mathie A, Rosenberg P, Wisden W, Korpi ERet al., 2006, The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the α₂ adrenergic sedative dexmedetomidine, and cannabinoid agonists, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 317, Pages: 615-626, ISSN: 0022-3565

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• Citations: 69

Meuth SG, Aller MI, Munsch T, Schuhmacher T, Seidenbecher T, Meuth P, Kleinschnitz C, Pape HC, Wiendl H, Wisden W, Budde Tet al., 2006, The contribution of TWIK-related acid-sensitive K<SUP>+</SUP>-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons, MOLECULAR PHARMACOLOGY, Vol: 69, Pages: 1468-1476, ISSN: 0026-895X

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• Citations: 55

Aller MI, Veale EL, Linden AM, Sandu C, Schwaninger M, Evans LJ, Korpi ER, Mathie A, Wisden W, Brickley SGet al., 2005, Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons, JOURNAL OF NEUROSCIENCE, Vol: 25, Pages: 11455-11467, ISSN: 0270-6474

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• Citations: 116

Cope DW, Halbsguth C, Karayannis T, Wulff P, Ferraguti F, Hoeger H, Leppä E, Linden AM, Oberto A, Ogris W, Korpi ER, Sieghart W, Somogyi P, Wisden W, Capogna Met al., 2005, Loss of zolpidem efficacy in the hippocampus of mice with the GABA_A receptor γ2 F77I point mutation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 21, Pages: 3002-3016, ISSN: 0953-816X

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• Citations: 30

Merlo D, Di Stasi AMM, Bonini P, Mollinari C, Cardinale A, Cozzolino F, Wisden W, Garaci Eet al., 2005, DNA repair in post-mitotic neurons: a gene-trapping strategy, CELL DEATH AND DIFFERENTIATION, Vol: 12, Pages: 307-309, ISSN: 1350-9047

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• Citations: 20

Leppä E, Vekovischeva OY, Lindén AM, Wulff P, Oberto A, Wisden W, Korpi ERet al., 2005, Agonistic effects of the β-carboline DMCM revealed in GABA_A receptor γ2 subunit F77I point-mutated mice, NEUROPHARMACOLOGY, Vol: 48, Pages: 469-478, ISSN: 0028-3908

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• Citations: 20

Wulff P, Wisden W, 2005, Dissecting neural circuitry by combining genetics and pharmacology, TRENDS IN NEUROSCIENCES, Vol: 28, Pages: 44-50, ISSN: 0166-2236

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• Citations: 22

Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart Wet al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit., Biochem Pharmacol, Vol: 68, Pages: 1621-1629, ISSN: 0006-2952

The benzodiazepine binding site of GABA(A) receptors is located at the interface of the alpha and gamma subunits. Certain point mutations in these subunits have been demonstrated to dramatically reduce the affinity of benzodiazepine binding site ligands for these receptors. Recently, mice were generated with a phenylalanine (F) to isoleucine (I) substitution at position 77 in the gamma2 subunit of GABA(A) receptors. Here we tested the potency of 24 benzodiazepine binding site ligands from 16 different structural classes for inhibition of [(3)H]flunitrazepam binding to brain membranes of these gamma2F77I mice. Results indicate that the potency of the classical 1,4-benzodiazepines, of the 1,4-thienodiazepine clotiazepam, the 1,5-benzodiazepine clobazam, or the pyrazoloquinoline CGS 9896 is only 2-7-fold reduced by this gamma2F77I point mutation. The potency of the imidazopyrimidines Ru 32698, Ru 33203, and Ru 33356, of the imidazoquinoline Ru 31719, or the pyrazolopyridine CGS 20625 is reduced 10-20-fold, whereas the potency of some imidazobenzodiazepines, beta-carbolines, cyclopyrrolones, imidazopyridines, triazolopyridazines, or quinolines is 100-1000-fold reduced. Interestingly, the extent of potency reduction induced by the gamma2F77I point mutation varied within the structural classes of compounds. Results support and significantly extend previous observations indicating that the residue gamma2F77 is important for high affinity binding of some, but not all benzodiazepine site ligands.

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Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart Wet al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA_A receptor γ2 subunit, 6th Decades of GABA Conference, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 1621-1629, ISSN: 0006-2952

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• Citations: 38

Sinkkonen ST, Vekovischeva OY, Möykkynen T, Ogris W, Sieghart W, Wisden W, Korpi ERet al., 2004, Behavioural correlates of an altered balance between synaptic and extrasynaptic GABA_Aergic inhibition in a mouse model, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 20, Pages: 2168-2178, ISSN: 0953-816X

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• Citations: 21

Lauder AJ, Jolin HE, Smith P, van den Berg JG, Jones A, Wisden W, Smith KGC, Dasvarma A, Fallon PG, McKenzie ANJet al., 2004, Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 113-122, ISSN: 0022-1767

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• Citations: 13

Cope DW, Wulff P, Oberto A, Aller MI, Capogna M, Ferraguti F, Halbsguth C, Hoeger H, Jolin HE, Jones A, Mckenzie ANJ, Ogris W, Poeltl A, Sinkkonen ST, Vekovischeva OY, Korpi ER, Sieghart W, Sigel E, Somogyi P, Wisden Wet al., 2004, Abolition of zolpidem sensitivity in mice with a point mutation in the GABA_A receptor γ2 subunit, NEUROPHARMACOLOGY, Vol: 47, Pages: 17-34, ISSN: 0028-3908

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• Citations: 60

Aller MI, Jones A, Merlo D, Paterlini M, Meyer AH, Arntmann U, Brickley S, Jolin HE, McKenzie ANJ, Monyer H, Farrant M, Wisden Wet al., 2003, Cerebellar granule cell Cre recombinase expression, GENESIS, Vol: 36, Pages: 97-103, ISSN: 1526-954X

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• Citations: 38

Wisden W, Cope D, Klausberger T, Hauer B, Sinkkonen ST, Tretter V, Lujan R, Jones A, Korpi ER, Mody I, Sieghart W, Somogyi Pet al., 2002, Ectopic expression of the GABA_A receptor α6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition, NEUROPHARMACOLOGY, Vol: 43, Pages: 530-549, ISSN: 0028-3908

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• Citations: 60

Wisden W, Morris BJ, 2002, In situ hybridization protocols for the brain -second edition, Publisher: Academic Pr, ISBN: 9780123668479

This volume of the International Review of Neurobiology was written to assist researchers without any previous experience with in situ hybridization, allowing ...

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Wisden B, Morris B, 2002, Acknowledgements, International Review of Neurobiology, Vol: 47, ISSN: 0074-7742

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Wisden W, Morris BJ, 2002, Introduction: studying gene expression in neural tissues by in situ hybridization., Int Rev Neurobiol, Vol: 47, Pages: xvii-xxi, ISSN: 0074-7742

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Wisden W, Farrant M, 2002, Insights into GABA-A receptor complexity from the study of cerebellar granule cells: synaptic and extrasynaptic receptors., Glutamate and GABA receptors and transporters, Editors: Egebjerg, Krogsgaard-Larsen, Schousboe, Publisher: CRC, Pages: 189-201, ISBN: 9780748408818

This book conveys recent discoveries in a framework of the basic concepts in the fieldof glutamate and GABA receptor research.

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Wisden W, Morris BJ, 2002, Introduction:: Studying gene expression in neural tissues by <i>in situ</i> hybridization, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: XVII-XXI, ISSN: 0074-7742

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• Citations: 1

Wisden W, Morris BJ, 2002, <i>In situ</i> hybridization with oligonucleotide probes, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: 3-59, ISSN: 0074-7742

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• Citations: 29

Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, Wisden W, Triller A, Smart TG, Moss SJet al., 2001, GABA_A receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1, NATURE NEUROSCIENCE, Vol: 4, Pages: 908-916, ISSN: 1097-6256

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• Citations: 187

Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant Met al., 2001, Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance, NATURE, Vol: 409, Pages: 88-92, ISSN: 0028-0836

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• Citations: 454

Campos ML, De Cabo C, Wisden W, Juiz JM, Merlo Det al., 2001, Expression of GABA_A receptor subunits in rat brainstem auditory pathways:: Cochlear nuclei, superior olivary complex and nucleus of the lateral lemniscus, NEUROSCIENCE, Vol: 102, Pages: 625-638, ISSN: 0306-4522

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• Citations: 42

Wisden W, Seeburg PH, Monyer H, 2000, Chapter IV AMPA, kainate and NMDA ionotropic glutamate receptor expression-an in situ hybridization atlas, Handbook of Chemical Neuroanatomy, Vol: 18, Pages: 99-143, ISSN: 0924-8196

Most rat neocortical neurons have Ca2+-impermeable AMPA receptors containing GluR-A/B, heteromeric receptors will be least numerous in layer IV cells (Fig. 11) (discussed by Conti et al., 1994a). Most GABAergic interneurons have Ca2+-permeable AMPA receptors made from GluR-A/D subunits; these receptors will have fast kinetics and high single-channel conductance. © 2000 Elsevier B.V. All rights reserved.

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• Citations: 21

Wisden W, Seeburg PH, Monyer H, 2000, AMPA, kainate and NMDA ionotropic glutamate receptor expression: an in situ hybridization atlas., Glutamate, Editors: Ottersen, Storm-Mathisen, Publisher: Elsevier Science Ltd, Pages: 99-143, ISBN: 9780444502865

The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment.

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Jones A, Paterlini M, Wisden W, Merlo Det al., 2000, Transgenic methods for directing gene expression to specific neuronal types: cerebellar granule cells., Progress in Brain Resaerch: Cerebellar modules: molecules, morphology and function, Editors: Gerrits, Ruigrok, De Zeeuw, Pages: 69-80, ISBN: 9780444801043

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Jones A, Paterlini M, Wisden W, Merlo Det al., 2000, Transgenic methods for directing gene expression to specific neuronal types: cerebellar granule cells, 2nd Symposium on Cerebellar Modules, Publisher: ELSEVIER SCIENCE BV, Pages: 69-80, ISSN: 0079-6123

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• Citations: 5

Wisden W, 2000, Technical workshop: Ligand-gated ion channel diversity, Publisher: BLACKWELL SCIENCE LTD, Pages: 382-382, ISSN: 0953-816X

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