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@article{Zhang:2021:10.1111/acel.13291,
author = {Zhang, Z and He, C and Gao, Y and Zhang, L and Song, Y and Zhu, T and Zhu, K and Lv, D and Wang, J and Tian, X and Ma, T and Ji, P and Cui, W and Liu, G},
doi = {10.1111/acel.13291},
journal = {Aging Cell},
pages = {1--15},
title = {alpha-ketoglutarate delays age-related fertility decline in mammals},
url = {http://dx.doi.org/10.1111/acel.13291},
volume = {20},
year = {2021}
}

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TY  - JOUR
AB  - The fecundity reduction with aging is referred as the reproductive aging which comes earlier than that of chronological aging. Since humans have postponed their childbearing age, to prolong the reproductive age becomes urgent agenda for reproductive biologists. In the current study, we examined the potential associations of αketoglutarate (αKG) and reproductive aging in mammals including mice, swine, and humans. There is a clear tendency of reduced αKG level with aging in the follicle fluids of human. To explore the mechanisms, mice were selected as the convenient animal model. It is observed that a long term of αKG administration preserves the ovarian function, the quality and quantity of oocytes as well as the telomere maintaining system in mice. αKG suppresses ATP synthase and alterations of the energy metabolism trigger the nutritional sensors to downregulate mTOR pathway. These events not only benefit the general aging process but also maintain ovarian function and delay the reproductive decline. Considering the safety of the αKG as a naturally occurring molecule in energy metabolism, its utility in reproduction of large mammals including humans deserves further investigation.
AU  - Zhang,Z
AU  - He,C
AU  - Gao,Y
AU  - Zhang,L
AU  - Song,Y
AU  - Zhu,T
AU  - Zhu,K
AU  - Lv,D
AU  - Wang,J
AU  - Tian,X
AU  - Ma,T
AU  - Ji,P
AU  - Cui,W
AU  - Liu,G
DO  - 10.1111/acel.13291
EP  - 15
PY  - 2021///
SN  - 1474-9718
SP  - 1
TI  - alpha-ketoglutarate delays age-related fertility decline in mammals
T2  - Aging Cell
UR  - http://dx.doi.org/10.1111/acel.13291
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000607735000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/acel.13291
UR  - http://hdl.handle.net/10044/1/85989
VL  - 20
ER  -

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