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@article{Dai:2009:2009/162824,
author = {Dai, W and Sheikh, MA and Milenkovic, O and Baraniuk, RG},
doi = {2009/162824},
journal = {Eurasip Journal on Bioinformatics and Systems Biology},
pages = {12 pages--12 pages},
title = {Compressive Sensing DNA Microarrays},
url = {http://dx.doi.org/10.1155/2009/162824},
volume = {2009},
year = {2009}
}

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TY  - JOUR
AB  - Compressive sensing microarrays (CSMs) are DNA-based sensors that operate using group testing and compressive sensing (CS)principles. In contrast to conventional DNA microarrays, in which each genetic sensor is designed to respond to a single target,in a CSM, each sensor responds to a set of targets. We study the problem of designing CSMs that simultaneously account forboth the constraints from CS theory and the biochemistry of probe-target DNA hybridization. An appropriate cross-hybridizationmodel is proposed for CSMs, and several methods are developed for probe design and CS signal recovery based on the new model.Lab experiments suggest that in order to achieve accurate hybridization profiling, consensus probe sequences are required to havesequence homology of at least 80% with all targets to be detected. Furthermore, out-of-equilibrium datasets are usually as accurateas those obtained from equilibrium conditions. Consequently, one can use CSMs in applications in which only short hybridizationtimes are allowed.
AU  - Dai,W
AU  - Sheikh,MA
AU  - Milenkovic,O
AU  - Baraniuk,RG
DO  - 2009/162824
EP  - 12
PY  - 2009///
SN  - 1687-4153
SP  - 12
TI  - Compressive Sensing DNA Microarrays
T2  - Eurasip Journal on Bioinformatics and Systems Biology
UR  - http://dx.doi.org/10.1155/2009/162824
UR  - http://hdl.handle.net/10044/1/28335
VL  - 2009
ER  -

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