Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3622x.didelot

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Whittles:2018:10.3390/antibiotics7030060,
author = {Whittles, L and White, PJ and Paul, J and Didelot, X},
doi = {10.3390/antibiotics7030060},
journal = {Antibiotics},
title = {Epidemiological trends of antibiotic resistant gonorrhoea in the United Kingdom},
url = {http://dx.doi.org/10.3390/antibiotics7030060},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gonorrhoea is one of the most common sexually-transmitted bacterial infections, globally and in the United Kingdom. The levels of antibiotic resistance in gonorrhoea reported in recent years represent a critical public health issue. From penicillins to cefixime, the gonococcus has become resistant to all antibiotics that have been previously used against it, in each case only a matter of years after introduction as a first-line therapy. After each instance of resistance emergence, the treatment recommendations have required revision, to the point that only a few antibiotics can reliably be prescribed to treat infected individuals. Most countries, including the UK, now recommend that gonorrhoea be treated with a dual therapy combining ceftriaxone and azithromycin. While this treatment is still currently effective for the vast majority of cases, there are concerning signs that this will not always remain the case, and there is no readily apparent alternative. Here, we review the use of antibiotics and epidemiological trends of antibiotic resistance in gonorrhoea from surveillance data over the past 15 years in the UK and describe how surveillance could be improved.
AU  - Whittles,L
AU  - White,PJ
AU  - Paul,J
AU  - Didelot,X
DO  - 10.3390/antibiotics7030060
PY  - 2018///
SN  - 2079-6382
TI  - Epidemiological trends of antibiotic resistant gonorrhoea in the United Kingdom
T2  - Antibiotics
UR  - http://dx.doi.org/10.3390/antibiotics7030060
UR  - http://hdl.handle.net/10044/1/62283
VL  - 7
ER  -
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