Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3622x.didelot

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Séraphin:2018:10.4269/ajtmh.17-0700,
author = {Séraphin, MN and Didelot, X and Nolan, DJ and May, JR and Khan, MSR and Murray, ER and Salemi, M and Morris, JG and Lauzardo, M},
doi = {10.4269/ajtmh.17-0700},
journal = {American Journal of Tropical Medicine and Hygiene},
pages = {867--874},
title = {Genomic investigation of a mycobacterium tuberculosis outbreak involving prison and community cases in Florida, United States},
url = {http://dx.doi.org/10.4269/ajtmh.17-0700},
volume = {99},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We used whole-genome sequencing to investigate a tuberculosis outbreak involving U.S.-born persons in the prison system and both U.S.- and foreign-born persons in the community in Florida over a 7-year period (2009-2015). Genotyping by spacer oligonucleotide typing and 24-locus mycobacterial interspersed repetitive unit-variable number tandem repeat suggested that the outbreak might be clonal in origin. However, contact tracing could not link the two populations. Through a multidisciplinary approach, we showed that the cluster involved distinct bacterial transmission networks segregated by country of birth. The source strain is of foreign origin and circulated in the local Florida community for more than 20 years before introduction into the prison system. We also identified novel transmission links involving foreign and U.S.-born cases not discovered during contact investigation. Our data highlight the potential for spread of strains originating from outside the United States into U.S. "high-risk" populations (such as prisoners), with subsequent movement back to the general community.
AU  - Séraphin,MN
AU  - Didelot,X
AU  - Nolan,DJ
AU  - May,JR
AU  - Khan,MSR
AU  - Murray,ER
AU  - Salemi,M
AU  - Morris,JG
AU  - Lauzardo,M
DO  - 10.4269/ajtmh.17-0700
EP  - 874
PY  - 2018///
SN  - 0002-9637
SP  - 867
TI  - Genomic investigation of a mycobacterium tuberculosis outbreak involving prison and community cases in Florida, United States
T2  - American Journal of Tropical Medicine and Hygiene
UR  - http://dx.doi.org/10.4269/ajtmh.17-0700
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29987998
UR  - http://hdl.handle.net/10044/1/62359
VL  - 99
ER  -
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