Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3622x.didelot

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fountain-Jones:2020:ve/veaa082,
author = {Fountain-Jones, NM and Appaw, RC and Carver, S and Didelot, X and Volz, E and Charleston, M},
doi = {ve/veaa082},
journal = {Virus Evol},
title = {Emerging phylogenetic structure of the SARS-CoV-2 pandemic.},
url = {http://dx.doi.org/10.1093/ve/veaa082},
volume = {6},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Since spilling over into humans, SARS-CoV-2 has rapidly spread across the globe, accumulating significant genetic diversity. The structure of this genetic diversity and whether it reveals epidemiological insights are fundamental questions for understanding the evolutionary trajectory of this virus. Here, we use a recently developed phylodynamic approach to uncover phylogenetic structures underlying the SARS-CoV-2 pandemic. We find support for three SARS-CoV-2 lineages co-circulating, each with significantly different demographic dynamics concordant with known epidemiological factors. For example, Lineage C emerged in Europe with a high growth rate in late February, just prior to the exponential increase in cases in several European countries. Non-synonymous mutations that characterize Lineage C occur in functionally important gene regions responsible for viral replication and cell entry. Even though Lineages A and B had distinct demographic patterns, they were much more difficult to distinguish. Continuous application of phylogenetic approaches to track the evolutionary epidemiology of SARS-CoV-2 lineages will be increasingly important to validate the efficacy of control efforts and monitor significant evolutionary events in the future.
AU  - Fountain-Jones,NM
AU  - Appaw,RC
AU  - Carver,S
AU  - Didelot,X
AU  - Volz,E
AU  - Charleston,M
DO  - ve/veaa082
PY  - 2020///
SN  - 2057-1577
TI  - Emerging phylogenetic structure of the SARS-CoV-2 pandemic.
T2  - Virus Evol
UR  - http://dx.doi.org/10.1093/ve/veaa082
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33335743
UR  - https://academic.oup.com/ve/article/6/2/veaa082/5970506
UR  - http://hdl.handle.net/10044/1/85695
VL  - 6
ER  -
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