Imperial College London

ProfessorXiao-NingXu

Faculty of MedicineDepartment of Medicine

Chair in Human Immunology
 
 
 
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Contact

 

+44 (0)20 3315 6558x.xu

 
 
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Assistant

 

Mrs Julie James +44 (0)20 3315 8258

 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Publication Type
Year
to

76 results found

Kaslow DC, Kalil J, Bloom D, Breghi G, Colucci AM, De Gregorio E, Madhavan G, Meier G, Seabrook R, Xu Xet al., 2017, The role of vaccines and vaccine decision-making to achieve the goals of the Grand Convergence in public health., Vaccine, Vol: 35 Suppl 1, Pages: A10-A15

On 17 and 18 July 2015, a meeting in Siena jointly sponsored by ADITEC and GlaxoSmithKline (GSK) was held to review the goals of the Global Health 2035 Grand Convergence, to discuss current vaccine evaluation methods, and to determine the feasibility of reaching consensus on an assessment framework for comprehensively and accurately capturing the full benefits of vaccines. Through lectures and workshops, participants reached a consensus that Multi-Criteria-Decision-Analysis is a method suited to systematically account for the many variables needed to evaluate the broad benefits of vaccination, which include not only health system savings, but also societal benefits, including benefits to the family and increased productivity. Participants also agreed on a set of "core values" to be used in future assessments of vaccines for development and introduction. These values include measures of vaccine efficacy and safety, incident cases prevented per year, the results of cost-benefit analyses, preventable mortality, and the severity of the target disease. Agreement on this set of core assessment parameters has the potential to increase alignment between manufacturers, public health agencies, non-governmental organizations (NGOs), and policy makers (see Global Health 2035 Mission Grand Convergence [1]). The following sections capture the deliberations of a workshop (Working Group 4) chartered to: (1) review the list of 24 parameters selected from SMART vaccines (see the companion papers by Timmis et al. and Madhavan et al., respectively) to determine which represent factors (see Table 1) that should be taken into account when evaluating the role of vaccines in maximizing the success of the Global Health 2035 Grand Convergence; (2) develop 3-5 "core values" that should be taken into account when evaluating vaccines at various stages of development; and (3) determine how vaccines can best contribute to the Global Health 2035 Grand Convergence effort.

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Jonsson P, Southcombe JH, Santos AM, Huo J, Fernandes RA, McColl J, Lever M, Evans EJ, Hudson A, Chang VT, Hanke T, Godkin A, Dunne PD, Horrocks MH, Palayret M, Screaton GR, Petersen J, Rossjohn J, Fugger L, Dushek O, Xu X-N, Davis SJ, Klenerman Det al., 2016, Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 5682-5687, ISSN: 0027-8424

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Wang Q, Yang H, Liu X, Dai L, Ma T, Qi J, Wong G, Peng R, Liu S, Li J, Li S, Song J, Liu J, He J, Yuan H, Xiong Y, Liao Y, Li J, Yang J, Tong Z, Griffin BD, Bi Y, Liang M, Xu X, Qin C, Cheng G, Zhang X, Wang P, Qiu X, Kobinger G, Shi Y, Yan J, Gao GFet al., 2016, Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus, SCIENCE TRANSLATIONAL MEDICINE, Vol: 8, ISSN: 1946-6234

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Chen Y, Li N, Zhang T, Huang X, Cai F, Vandergrift N, Xin R, Meng Z, Zhang X, Jiang C, Xu X, Montefiori DC, Gao F, Wu Het al., 2015, Comprehensive Characterization of the Transmitted/Founder env Genes From a Single MSM Cohort in China, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 69, Pages: 403-412, ISSN: 1525-4135

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Armitage AE, Stacey AR, Giannoulatou E, Marshall E, Sturges P, Chatha K, Smith NMG, Huang X, Xu X, Pasricha S-R, Li N, Wu H, Webster C, Prentice AM, Pellegrino P, Williams I, Norris PJ, Drakesmith H, Borrow Pet al., 2014, Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 12187-12192, ISSN: 0027-8424

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Gao S, Yang C, Jiang S, Xu X-N, Lu X, He Y-W, Cheung A, Wang Het al., 2014, Applications of RNA interference high-throughput screening technology in cancer biology and virology, PROTEIN & CELL, Vol: 5, Pages: 805-815, ISSN: 1674-800X

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Huang K-YA, Li CK-F, Clutterbuck E, Chui C, Wilkinson T, Gilbert A, Oxford J, Lambkin-Williams R, Lin T-Y, McMichael AJ, Xu X-Net al., 2014, Virus-Specific Antibody Secreting Cell, Memory B-cell, and Sero-Antibody Responses in the Human Influenza Challenge Model, JOURNAL OF INFECTIOUS DISEASES, Vol: 209, Pages: 1354-1361, ISSN: 0022-1899

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Huang X, Lodi S, Fox Z, Li W, Phillips A, Porter K, Lutsar I, Kelleher A, Li N, Xu X, Wu H, Johnson AMet al., 2013, Rate of CD4 Decline and HIV-RNA Change Following HIV Seroconversion in Men Who Have Sex With Men: A Comparison Between the Beijing PRIMO and CASCADE Cohorts, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 62, Pages: 441-446, ISSN: 1525-4135

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Johri AK, Lata H, Yadav P, Dua M, Yang Y, Xu X, Homma A, Barocchi MA, Bottomley MJ, Saul A, Klugman KP, Black Set al., 2013, Epidemiology of Group B Streptococcus in developing countries, VACCINE, Vol: 31, Pages: D43-D45, ISSN: 0264-410X

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Li CK-F, Rappuoli R, Xu X-N, 2013, Correlates of protection against influenza infection in humans - on the path to a universal vaccine?, CURRENT OPINION IN IMMUNOLOGY, Vol: 25, Pages: 470-476, ISSN: 0952-7915

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Li W-H, Li C-Y, Yang H-B, Zhang H-P, Zhang X, Kong L-S, Xu X-N, Lu S-C, Yan H-Pet al., 2013, Human leucocyte antigen-Bw4 and Gag-specific T cell responses are associated with slow disease progression in HIV-1B-infected anti-retroviral therapy-naive Chinese, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 171, Pages: 298-306, ISSN: 0009-9104

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Zhang X, Huang X, Xia W, Li W, Zhang T, Wu H, Xu X, Yan Het al., 2013, HLA-B star 44 Is Associated with a Lower Viral Set Point and Slow CD4 Decline in a Cohort of Chinese Homosexual Men Acutely Infected with HIV-1, CLINICAL AND VACCINE IMMUNOLOGY, Vol: 20, Pages: 1048-1054, ISSN: 1556-6811

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Zhou D, Zhang X, Li W, Xu X, Goonetilleke N, Yang H, Dong T, Yan Het al., 2013, Short Communication Broader T Cell Responses Directed Against Human Immunodeficiency Virus Type 1 in Infected Chinese Individuals Through Blood-Borne Transmission in Comparison with Mucosal Transmission, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 29, Pages: 89-93, ISSN: 0889-2229

JOURNAL ARTICLE

Li D, Hong A, Lu Q, Gao GF, Jin B, Screaton GR, Xu X-Net al., 2012, A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-like transcript 4, INTERNATIONAL IMMUNOLOGY, Vol: 24, Pages: 729-737, ISSN: 0953-8178

JOURNAL ARTICLE

Perkins MR, Ryschkewitsch C, Liebner JC, Monaco MCG, Himelfarb D, Ireland S, Roque A, Edward HL, Jensen PN, Remington G, Abraham T, Abraham J, Greenberg B, Kaufman C, LaGanke C, Monson NL, Xu X, Frohman E, Major EO, Douek DCet al., 2012, Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7374

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Rajapaksa US, Li D, Peng Y-C, McMichael AJ, Dong T, Xu X-Net al., 2012, HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 13353-13358, ISSN: 0027-8424

JOURNAL ARTICLE

Wilkinson TM, Li CKF, Chui CSC, Huang AKY, Perkins M, Liebner JC, Lambkin-Williams R, Gilbert A, Oxford J, Nicholas B, Staples KJ, Dong T, Douek DC, McMichael AJ, Xu X-Net al., 2012, Preexisting influenza-specific CD4(+) T cells correlate with disease protection against influenza challenge in humans, NATURE MEDICINE, Vol: 18, Pages: 274-280, ISSN: 1078-8956

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Yang H, Wu H, Hancock G, Clutton G, Sande N, Xu X, Yan H, Huang X, Angus B, Kuldanek K, Fidler S, Denny TN, Birks J, McMichael A, Dorrell Let al., 2012, Antiviral Inhibitory Capacity of CD8+ T cells Predicts the Rate of CD4+ T-Cell Decline in HIV-1 Infection, JOURNAL OF INFECTIOUS DISEASES, Vol: 206, Pages: 552-561, ISSN: 0022-1899

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Haig NA, Guan Z, Li D, McMichael A, Raetz CRH, Xu X-Net al., 2011, Identification of Self-lipids Presented by CD1c and CD1d Proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 37692-37701, ISSN: 0021-9258

JOURNAL ARTICLE

Wu J, Zhong X, Li CK-F, Zhou J-F, Lu M, Huang K-Y, Dong M, Liu Y, Luo F-J, Du N, Chui C, Liu L-Q, Smith NMG, Li B, Shi N-M, Song L-F, Gao Y, Wang D-Y, Wang X, Zhu W-F, Yan Y, Li Z, Chen J-T, McMichael AJ, Yin W-D, Xu X-N, Shu Yet al., 2011, Optimal vaccination strategies for 2009 pandemic H1N1 and seasonal influenza vaccines in humans, VACCINE, Vol: 29, Pages: 1009-1016, ISSN: 0264-410X

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Zhang Y, Peng Y, Yan H, Xu K, Saito M, Wu H, Chen X, Ranasinghe S, Kuse N, Powell T, Zhao Y, Li W, Zhang X, Feng X, Li N, Leligdowicz A, Xu X, John M, Takiguchi M, McMichael A, Rowland-Jones S, Dong Tet al., 2011, Multilayered Defense in HLA-B51-Associated HIV Viral Control, JOURNAL OF IMMUNOLOGY, Vol: 187, Pages: 684-691, ISSN: 0022-1767

JOURNAL ARTICLE

Freundt EC, Yu L, Goldsmith CS, Welsh S, Cheng A, Yount B, Liu W, Frieman MB, Buchholz UJ, Screaton GR, Lippincott-Schwartz J, Zaki SR, Xu X-N, Baric RS, Subbarao K, Lenardo MJet al., 2010, The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death, JOURNAL OF VIROLOGY, Vol: 84, Pages: 1097-1109, ISSN: 0022-538X

JOURNAL ARTICLE

Hong H, Gu Y, Zhang H, Simon AK, Chen X, Wu C, Xu X-N, Jiang Set al., 2010, Depletion of CD4+CD25+regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 159, Pages: 93-99, ISSN: 0009-9104

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Liu W, de Vlas SJ, Tang F, Ma M-J, Wei M-T, Liu L-J, Li Z-D, Zhang L, Xin Z-T, Tong Y-G, Jiang T, Zhang X-A, He C, Li C, Xu X-N, Yang H, Richardus JH, Cao W-Cet al., 2010, Clinical and Immunological Characteristics of Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection after Vaccination, CLINICAL INFECTIOUS DISEASES, Vol: 51, Pages: 1028-1032, ISSN: 1058-4838

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Shu Y, Li CK-F, Li Z, Gao R, Liang Q, Zhang Y, Dong L, Zhou J, Dong J, Wang D, Wen L, Wang M, Bai T, Li D, Dong X, Yu H, Yang W, Wang Y, Feng Z, McMichael AJ, Xu X-Net al., 2010, Avian Influenza A(H5N1) Viruses Can Directly Infect and Replicate in Human Gut Tissues, JOURNAL OF INFECTIOUS DISEASES, Vol: 201, Pages: 1173-1177, ISSN: 0022-1899

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Bangs SC, Baban D, Cattan HJ, Li CK-F, McMichael AJ, Xu X-Net al., 2009, Human CD4(+) Memory T Cells Are Preferential Targets for Bystander Activation and Apoptosis, JOURNAL OF IMMUNOLOGY, Vol: 182, Pages: 1962-1971, ISSN: 0022-1767

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Dharmapatni AASSK, Smith MD, Findlay DM, Holding CA, Evdokiou A, Ahern MJ, Weedon H, Chen P, Screaton G, Xu XN, Haynes DRet al., 2009, Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium, ARTHRITIS RESEARCH & THERAPY, Vol: 11, ISSN: 1478-6354

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Dong T, Zhang Y, Xu K, Yan H, James I, Peng Y, Blais M, Gaudieri S, Chen X, Lun W, Wu H, Qu W, Zhao C, Li N, Mao Y, Rostron T, Mallal S, Xu X, McMichael A, John M, Rowland-Jones Set al., 2009, Extensive HLA-driven viral diversity following a single-source HIV-1 outbreak in rural China, RETROVIROLOGY, Vol: 6, ISSN: 1742-4690

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Fan S, Gao Y, Shinya K, Li CK, Li Y, Shi J, Jiang Y, Suo Y, Tong T, Zhong G, Song J, Zhang Y, Tian G, Guan Y, Xu X-N, Bu Z, Kawaoka Y, Chen Het al., 2009, Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366

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Freundt EC, Yu L, Park E, Lenardo MJ, Xu X-Net al., 2009, Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein, JOURNAL OF VIROLOGY, Vol: 83, Pages: 6631-6640, ISSN: 0022-538X

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