Publications
89 results found
Iversen AKN, Stewart-Jones G, Learn GH, et al., 2006, Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope, NATURE IMMUNOLOGY, Vol: 7, Pages: 179-189, ISSN: 1529-2908
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- Citations: 78
Chan VSF, Chan KYK, Chen Y, et al., 2006, Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection., Nat Genet, Vol: 38, Pages: 38-46
Ch'en PFT, Xu XG, Liu XS, et al., 2005, Characterisation of monoclonal antibodies to the TNF and TNF receptor families, CELLULAR IMMUNOLOGY, Vol: 236, Pages: 78-85, ISSN: 0008-8749
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- Citations: 13
Daniels RA, Turley H, Kimberley FC, et al., 2005, Expression of TRAIL and TRAIL receptors in normal and malignant tissues, CELL RESEARCH, Vol: 15, Pages: 430-438, ISSN: 1001-0602
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- Citations: 127
Drakesmith H, Chen N, Ledermann H, et al., 2005, HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis, Proc Natl Acad Sci U S A, Vol: 102, Pages: 11017-11022, ISSN: 0027-8424
Dong T, Stewart-Jones G, Chen N, et al., 2004, HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor, Journal of Experimental Medicine, Vol: 200, Pages: 1547-1557, ISSN: 0022-1007
HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease progression we identified Vβ13.2 T cell receptors (TCRs) with very similar and unusually long β-chain complementarity determining region 3 (CDR3) regions in CTL specific for the immunodominant human histocompatibility leukocyte antigens (HLA)-B8–restricted human immunodeficiency virus-1 (HIV-1) nef epitope, FLKEKGGL (FL8). CTL expressing Vβ13.2 TCRs tolerate naturally arising viral variants in the FL8 epitope that escape recognition by other CTL. In addition, they expand efficiently in vitro and are resistant to apoptosis, in contrast to FL8–specific CTL using other TCRs. Selection of Vβ13.2 TCRs by some patients early in the FL8-specific CTL response may be linked with better clinical outcome.
Nkolola JP, Wee EGT, Im EJ, et al., 2004, Engineering RENTA, a DNA prime-MVA boost HIV vaccine tailored for eastern and central Africa, GENE THERAPY, Vol: 11, Pages: 1068-1080, ISSN: 0969-7128
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- Citations: 33
Mongkolsapaya J, Dejnirattisai W, Xu XN, et al., 2003, Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever, NATURE MEDICINE, Vol: 9, Pages: 921-927, ISSN: 1078-8956
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- Citations: 615
Xu XN, Screaton GR, 2002, MHC/peptide tetramer-based studies of T cell function, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 268, Pages: 21-28, ISSN: 0022-1759
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- Citations: 20
Xu XN, Screaton GR, McMichael AJ, 2001, Virus infections: Escape, resistance, and counterattack, IMMUNITY, Vol: 15, Pages: 867-870, ISSN: 1074-7613
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- Citations: 58
Xu XN, Screaton G, 2001, HIV-1 Nef: negative effector of Fas?, NATURE IMMUNOLOGY, Vol: 2, Pages: 384-385, ISSN: 1529-2908
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- Citations: 7
Simon AK, Williams O, Mongkolsapaya J, et al., 2001, Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: Sensitivity of human thymocytes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 98, Pages: 5158-5163, ISSN: 0027-8424
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- Citations: 55
Simon AK, Williams O, Mongkolsapaya J, et al., 2001, Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: sensitivity of human thymocytes., Proc Natl Acad Sci U S A, Vol: 98, Pages: 5158-5163, ISSN: 0027-8424
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of the tumor necrosis factor cytokine superfamily. TRAIL has been shown to induce apoptosis in various tumor cell lines, whereas most primary cells seem to be resistant. These observations have raised considerable interest in the use of TRAIL in tumor therapy. Yet little is known about the physiological function of TRAIL. This is particularly the case in the immune system, where TRAIL has been suggested by some to be involved in target cell killing and lymphocyte death. We have developed a panel of mAbs and soluble proteins to address the role of TRAIL in lymphocyte development. These studies demonstrate activation-induced sensitization of thymocytes to TRAIL-mediated apoptosis and expression of the apoptosis-inducing TRAIL receptors. However, with the use of several model systems, our subsequent experiments rule out the possibility that TRAIL plays a major role in antigen-induced deletion of thymocytes. In contrast to thymocytes, there is no up-regulation of TRAIL receptors in peripheral T cells on activation, which remain resistant to TRAIL. Thus, susceptibility to TRAIL-induced apoptosis is controlled differently by central and peripheral T cells.
Xu XN, Purbhoo MA, Chen N, et al., 2001, A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha three domain mutants of MHC class I/peptide complex, Immunity, Vol: 14, Pages: 591-602, ISSN: 1074-7613
Screaton G, Xu XN, 2000, T cell life and death signalling via TNF-receptor family members, CURRENT OPINION IN IMMUNOLOGY, Vol: 12, Pages: 316-322, ISSN: 0952-7915
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- Citations: 90
Brodie D, Collins AV, Iaboni A, et al., 2000, LICOS, a primordial costimulatory ligand?, CURRENT BIOLOGY, Vol: 10, Pages: 333-336, ISSN: 0960-9822
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- Citations: 105
Mongkolsapaya J, Grimes JM, Chen N, et al., 1999, Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation, NATURE STRUCTURAL BIOLOGY, Vol: 6, Pages: 1048-1053, ISSN: 1072-8368
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- Citations: 223
Xu XN, Laffert B, Screaton GR, et al., 1999, Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor ζ chain, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 189, Pages: 1489-1496, ISSN: 0022-1007
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- Citations: 211
Tan RS, Xu XN, Ogg GS, et al., 1999, Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome, BLOOD, Vol: 93, Pages: 1506-1510, ISSN: 0006-4971
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- Citations: 105
Mongkolsapaya J, Cowper AE, Xu XN, et al., 1998, Cutting edge: Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): A new receptor protecting lymphocytes from the death ligand TRAIL, JOURNAL OF IMMUNOLOGY, Vol: 160, Pages: 3-6, ISSN: 0022-1767
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- Citations: 123
Screaton GR, Mongkolsapaya J, Xu XN, et al., 1997, TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL, CURRENT BIOLOGY, Vol: 7, Pages: 693-696, ISSN: 0960-9822
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- Citations: 277
McMichael A, Goulder P, Rowland-Jones S, et al., 1997, Escape from immune control by HIV, FASEB JOURNAL, Vol: 11, Pages: A1003-A1003, ISSN: 0892-6638
Xu XN, Screaton GR, Gotch FM, et al., 1997, Evasion of cytotoxic T lymphocyte (CTL) responses by Nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 186, Pages: 7-16, ISSN: 0022-1007
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- Citations: 161
Screaton GR, Xu XN, Olsen AL, et al., 1997, LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 94, Pages: 4615-4619, ISSN: 0027-8424
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- Citations: 179
XU XN, BECKMAN I, AHERN M, et al., 1993, A COMPREHENSIVE ANALYSIS OF PERIPHERAL-BLOOD LYMPHOCYTES IN HEALTHY AGED HUMANS BY FLOW-CYTOMETRY, IMMUNOLOGY AND CELL BIOLOGY, Vol: 71, Pages: 549-557, ISSN: 0818-9641
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- Citations: 60
XU XN, BECKMAN I, BRADLEY J, 1993, AGE-RELATED-CHANGES IN THE EXPRESSION OF IL-2 AND HIGH-AFFINITY IL-2-BINDING SITES, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol: 102, Pages: 224-231, ISSN: 1018-2438
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- Citations: 12
XU XN, BECKMAN I, DIMOPOULOS K, et al., 1992, AGE-RELATED-CHANGES IN THE EXPRESSION OF T-CELL ACTIVATION ANTIGENS FOLLOWING PHYTOHEMAGGLUTININ STIMULATION, EXPERIMENTAL AND CLINICAL IMMUNOGENETICS, Vol: 9, Pages: 203-211, ISSN: 0254-9670
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- Citations: 23
BECKMAN I, DIMOPOULOS K, XU XN, et al., 1991, AGE-RELATED-CHANGES IN THE ACTIVATION REQUIREMENTS OF HUMAN CD4+ T-CELL SUBSETS, CELLULAR IMMUNOLOGY, Vol: 132, Pages: 17-25, ISSN: 0008-8749
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- Citations: 39
BECKMAN I, DIMOPOULOS K, XU XN, et al., 1990, T-CELL ACTIVATION IN THE ELDERLY - EVIDENCE FOR SPECIFIC DEFICIENCIES IN T-CELL ACCESSORY CELL-INTERACTIONS, MECHANISMS OF AGEING AND DEVELOPMENT, Vol: 51, Pages: 265-276, ISSN: 0047-6374
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- Citations: 50
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