Imperial College London
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ProfessorXiaodongZhang

Faculty of Medicine, Department of Infectious Disease

Professor of Macromolecular Structure and Function
 
 
 
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Contact

 

+44 (0)20 7594 3151xiaodong.zhang Website

 
 
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Assistant

 

Miss Kelly Butler +44 (0)20 7594 2763

 
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Location

 

104Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Danson:2019:10.1016/j.jmb.2019.04.022,
author = {Danson, A and Jovanovic, M and Buck, M and Zhang, X},
doi = {10.1016/j.jmb.2019.04.022},
journal = {Journal of Molecular Biology},
title = {Mechanisms of s54-dependent transcription initiation and regulation},
url = {http://dx.doi.org/10.1016/j.jmb.2019.04.022},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cellular RNA polymerase is a multi-subunit macromolecular assembly responsible for gene transcription, a highly regulated process conserved from bacteria to humans. In bacteria, sigma factors are employed to mediate gene-specific expression in response to a variety of environmental conditions. The major variant σ factor, σ54, has a specific role in stress responses. Unlike σ70-dependent transcription, which often can spontaneously proceed to initiation, σ54-dependent transcription requires an additional ATPase protein for activation. As a result, structures of a number of distinct functional states during the dynamic process of transcription initiation have been captured using the σ54 system with both x-ray crystallography and cryo electron microscopy, furthering our understanding of σ54-dependent transcription initiation and DNA opening. Comparisons with σ70 and eukaryotic polymerases reveal unique and common features during transcription initiation.
AU  - Danson,A
AU  - Jovanovic,M
AU  - Buck,M
AU  - Zhang,X
DO  - 10.1016/j.jmb.2019.04.022
PY  - 2019///
SN  - 0022-2836
TI  - Mechanisms of s54-dependent transcription initiation and regulation
T2  - Journal of Molecular Biology
UR  - http://dx.doi.org/10.1016/j.jmb.2019.04.022
UR  - http://hdl.handle.net/10044/1/70236
ER  -
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