Imperial College London
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ProfessorXiaodongZhang

Faculty of Medicine, Department of Infectious Disease

Professor of Macromolecular Structure and Function
 
 
 
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Contact

 

+44 (0)20 7594 3151xiaodong.zhang Website

 
 
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Assistant

 

Miss Kelly Butler +44 (0)20 7594 2763

 
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Location

 

104Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Williams:2020:10.1016/j.sbi.2019.12.010,
author = {Williams, R and Yates, L and Zhang, X},
doi = {10.1016/j.sbi.2019.12.010},
journal = {Current Opinion in Structural Biology},
pages = {98--105},
title = {Structures and regulations of ATM and ATR, master kinases in genome integrity},
url = {http://dx.doi.org/10.1016/j.sbi.2019.12.010},
volume = {61},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Homologous recombination (HR) is a faithful repair mechanism for double stranded DNA breaks. Two highly homologous master kinases, the tumour suppressors ATM and ATR (Tel1 and Mec1 in yeast), coordinate cell cycle progression with repair during HR. Despite their importance, our molecular understanding of these apical coordinators has been limited, in part due to their large sizes. With the recent development in cryo-electron microscopy, significant advances have been made in structural characterisation of these proteins in the last two years. These structures, combined with new biochemical studies, now provide a more detailed understanding of how a low basal activity is maintained and how activation may occur. In this review, we summarize recent advances in the structural and molecular understanding of these key components in HR, compare the common and distinct features of these kinases and suggest aspects of structural components that are likely to be involved in regulating its activity.
AU  - Williams,R
AU  - Yates,L
AU  - Zhang,X
DO  - 10.1016/j.sbi.2019.12.010
EP  - 105
PY  - 2020///
SN  - 0959-440X
SP  - 98
TI  - Structures and regulations of ATM and ATR, master kinases in genome integrity
T2  - Current Opinion in Structural Biology
UR  - http://dx.doi.org/10.1016/j.sbi.2019.12.010
UR  - http://hdl.handle.net/10044/1/76396
VL  - 61
ER  -
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