Imperial College London

DrYanLiu

Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Research Fellow
 
 
 
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Contact

 

yan.liu06

 
 
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Location

 

Electrical EngineeringSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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25 results found

Liu Y, Pereira JL, Constandinou TG, 2018, Event-driven processing for hardware-efficient neural spike sorting, JOURNAL OF NEURAL ENGINEERING, Vol: 15, ISSN: 1741-2560

JOURNAL ARTICLE

Luan S, Williams I, Maslik M, Liu Y, De Carvalho F, Jackson A, Quiroga RQ, Constandinou TGet al., 2018, Compact standalone platform for neural recording with real-time spike sorting and data logging., J Neural Eng, Vol: 15

OBJECTIVE: Longitudinal observation of single unit neural activity from large numbers of cortical neurons in awake and mobile animals is often a vital step in studying neural network behaviour and towards the prospect of building effective brain-machine interfaces (BMIs). These recordings generate enormous amounts of data for transmission and storage, and typically require offline processing to tease out the behaviour of individual neurons. Our aim was to create a compact system capable of: (1) reducing the data bandwidth by circa 2 to 3 orders of magnitude (greatly improving battery lifetime and enabling low power wireless transmission in future versions); (2) producing real-time, low-latency, spike sorted data; and (3) long term untethered operation. APPROACH: We have developed a headstage that operates in two phases. In the short training phase a computer is attached and classic spike sorting is performed to generate templates. In the second phase the system is untethered and performs template matching to create an event driven spike output that is logged to a micro-SD card. To enable validation the system is capable of logging the high bandwidth raw neural signal data as well as the spike sorted data. MAIN RESULTS: The system can successfully record 32 channels of raw neural signal data and/or spike sorted events for well over 24 h at a time and is robust to power dropouts during battery changes as well as SD card replacement. A 24 h initial recording in a non-human primate M1 showed consistent spike shapes with the expected changes in neural activity during awake behaviour and sleep cycles. SIGNIFICANCE: The presented platform allows neural activity to be unobtrusively monitored and processed in real-time in freely behaving untethered animals-revealing insights that are not attainable through scheduled recording sessions. This system achieves the lowest power per channel to date and provides a robust, low-latency, low-bandwidth and verifiable outp

JOURNAL ARTICLE

Maslik M, Liu Y, Lande TS, Constandinou TGet al., 2018, Continuous-Time Acquisition of Biosignals Using a Charge-Based ADC Topology, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 12, Pages: 471-482, ISSN: 1932-4545

JOURNAL ARTICLE

Ramezani R, Liu Y, Dehkhoda F, Soltan A, Haci D, Zhao H, Firfilionis D, Hazra A, Cunningham MO, Jackson A, Constandinou TG, Degenaar Pet al., 2018, On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 12, Pages: 576-588, ISSN: 1932-4545

JOURNAL ARTICLE

Gao C, Ghoreishizadeh S, Liu Y, Constandinou Tet al., 2017, On-chip ID Generation for Multi-node Implantable Devices using SA-PUF, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 678-681, ISSN: 0271-4302

CONFERENCE PAPER

Ghoreishizadeh SS, Haci D, Liu Y, Constandinou TGet al., 2017, A 4-Wire Interface SoC for Shared Multi- Implant Power Transfer and Full-duplex Communication, 8th IEEE Latin American Symposium on Circuits & Systems (LASCAS), Publisher: IEEE

CONFERENCE PAPER

Ghoreishizadeh SS, Haci D, Liu Y, Donaldson N, Constandinou TGet al., 2017, Four-Wire Interface ASIC for a Multi-Implant Link, IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, Vol: 64, Pages: 3056-3067, ISSN: 1549-8328

JOURNAL ARTICLE

Haci D, Liu Y, Constandinou TG, 2017, 32-Channel Ultra-Low-Noise Arbitrary Signal Generation Platform for Biopotential Emulation, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 698-701, ISSN: 0271-4302

CONFERENCE PAPER

Liu Y, Luan S, Williams I, Rapeaux A, Constandinou TGet al., 2017, A 64-Channel Versatile Neural Recording SoC With Activity-Dependent Data Throughput, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 11, Pages: 1344-1355, ISSN: 1932-4545

JOURNAL ARTICLE

Luo J, Firfilionis D, Ramezani R, Dehkhoda F, Soltan A, Degenaar P, Liu Y, Constandinou TGet al., 2017, Live demonstration: a closed-loop cortical brain implant for optogenetic curing epilepsy, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Publisher: IEEE, Pages: 169-169

CONFERENCE PAPER

Maslik M, Liu Y, Lande TSB, Constandinou TGet al., 2017, A Charge-Based Ultra-Low Power Continuous-Time ADC for Data Driven Neural Spike Processing, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, ISSN: 0271-4302

CONFERENCE PAPER

Liu Y, Pereira JL, Constandinou TG, 2016, Clockless Continuous-Time Neural Spike Sorting: Method, Implementation and Evaluation, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 538-541, ISSN: 0271-4302

CONFERENCE PAPER

Luan S, Liu Y, Williams I, Constandinou TGet al., 2016, An Event-Driven SoC for Neural Recording, 12th IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 404-407, ISSN: 2163-4025

CONFERENCE PAPER

Ramezani R, Dehkhoda F, Soltan A, Degenaar P, Liu Y, Constandinou Tet al., 2016, An Optrode with built-in self-diagnostic and fracture sensor for cortical brain stimulation, 12th IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 392-395, ISSN: 2163-4025

CONFERENCE PAPER

Williams I, Rapeaux A, Liu Y, Luan S, Constandinou TGet al., 2016, A 32-Ch. Bidirectional Neural/EMG Interface with on-Chip Spike Detection for Sensorimotor Feedback, 12th IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 528-531, ISSN: 2163-4025

CONFERENCE PAPER

Dehkhoda F, Soltan A, Ramezani R, Zhao H, Liu Y, Constandinou T, Degenaar Pet al., 2015, Smart Optrode for Neural Stimulation and Sensing, 2015 IEEE SENSORS, Publisher: IEEE, Pages: 1965-1968, ISSN: 1930-0395

CONFERENCE PAPER

Zhao H, Dehkhoda F, Ramezani R, Sokolov D, Degenaar P, Liu Y, Constandinou Tet al., 2015, A CMOS-based Neural Implantable Optrode for Optogenetic Stimulation and Electrical Recording, 11th IEEE Annual Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 286-289, ISSN: 2163-4025

CONFERENCE PAPER

Barsakcioglu DY, Liu Y, Bhunjun P, Navajas J, Eftekhar A, Jackson A, Quiroga RQ, Constandinou TGet al., 2014, An Analogue Front-End Model for Developing Neural Spike Sorting Systems, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 8, Pages: 216-227, ISSN: 1932-4545

JOURNAL ARTICLE

Reverter F, Prodromakis T, Liu Y, Georgiou P, Nikolic K, Constandinou Tet al., 2014, Design Considerations for a CMOS Lab-on-Chip Microheater Array to Facilitate the in vitro Thermal Stimulation of Neurons, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 630-633, ISSN: 0271-4302

CONFERENCE PAPER

Hu Y, Liu Y, Toumazou C, Georgiou Pet al., 2012, A CMOS architecture allowing parallel DNA comparison for on-chip assembly, IEEE International Symposium on Circuits and Systems, Publisher: IEEE, Pages: 1544-1547, ISSN: 0271-4302

CONFERENCE PAPER

Sohbati M, Liu Y, Georgiou P, Toumazou Cet al., 2012, An ISFET Design Methodology Incorporating CMOS Passivation, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 65-68, ISSN: 2163-4025

CONFERENCE PAPER

Wang K, Liu Y, Toumazou C, Georgiou Pet al., 2012, A TDC Based ISFET Readout for Large-Scale Chemical Sensing Systems, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 176-179, ISSN: 2163-4025

CONFERENCE PAPER

Liu Y, Georgiou P, Prodromakis T, Constandinou TG, Toumazou Cet al., 2011, An Extended CMOS ISFET Model Incorporating the Physical Design Geometry and the Effects on Performance and Offset Variation, IEEE TRANSACTIONS ON ELECTRON DEVICES, Vol: 58, Pages: 4414-4422, ISSN: 0018-9383

JOURNAL ARTICLE

Prodromakis T, Liu Y, Toumazou C, 2011, A Low-Cost Disposable Chemical Sensing Platform Based on Discrete Components, IEEE ELECTRON DEVICE LETTERS, Vol: 32, Pages: 417-419, ISSN: 0741-3106

JOURNAL ARTICLE

Prodromakis T, Liu Y, Constandinou T, Georgiou P, Toumazou Cet al., 2010, Exploiting CMOS Technology to Enhance the Performance of ISFET Sensors, IEEE ELECTRON DEVICE LETTERS, Vol: 31, Pages: 1053-1055, ISSN: 0741-3106

JOURNAL ARTICLE

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