Imperial College London
Alternate

Professor Xiao Yun Xu

Faculty of Engineering, Department of Chemical Engineering

Professor, Biofluid Mechanics & Director of Graduate School
 
 
 
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Contact

 

yun.xu Website

 
 
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Location

 

407ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Armour:2020:10.1177/1526602820917962,
author = {Armour, C and Menichini, C and Milinis, K and Gibbs, R and Xu, X},
doi = {10.1177/1526602820917962},
journal = {Journal of Endovascular Therapy},
pages = {396--404},
title = {The location of re-entry tears affects false lumen thrombosis in aortic dissection following TEVAR},
url = {http://dx.doi.org/10.1177/1526602820917962},
volume = {27},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose. Thoracic  endovascular  aortic  repair (TEVAR) has  been shown  to  be  an  effective  treatment method for acute type B aortic dissection. However, it remains unclear which factors determine false lumen thrombosis (FLT) after TEVAR. In this study we assess the influence of the distance between the distal end of the stent graft and first re-entry tear (SG-FET)on the progression of FLT.Methods.Three post-operative patient-specific models were reconstructed from computed tomography scans. Two additional models  were created byartificially changing the  SG-FET distance in patient 1 and 2. In all five models, computational fluid dynamics simulations coupled with thrombus formation modelling were performed  at  physiological  flow  conditions.Predicted  FLT was  compared  with follow-up scans.Results.Ourresults  showed  reduced false  lumen flow  and  low  time-averaged  wall  shear  stress (TAWSS) inpatients withlarge  SG-FET  distances. Predicted  thrombus formation  and  growth  were consistent with follow-up scansfor all patients. Reducingthe SG-FET distanceby 30 mm in patient 1 increased  flowandTAWSS in  the  upper  abdominal false  lumen,  reducing the thrombus  volume  by 9.6%. Increasingthe SG-FET distance inpatient 2 resulted in fasterthoracic thrombosis and increased total thrombus volume.Conclusion.The  location  of re-entry  tears can influencethe  progression  of FLT following  TEVAR. The more distal the re-entry tear in the aorta the more likely FLTis. Hence, the distal landing zone of the stent graft should be chosen carefully to ensure a sufficient SG-FET distance.
AU  - Armour,C
AU  - Menichini,C
AU  - Milinis,K
AU  - Gibbs,R
AU  - Xu,X
DO  - 10.1177/1526602820917962
EP  - 404
PY  - 2020///
SN  - 1074-6218
SP  - 396
TI  - The location of re-entry tears affects false lumen thrombosis in aortic dissection following TEVAR
T2  - Journal of Endovascular Therapy
UR  - http://dx.doi.org/10.1177/1526602820917962
UR  - http://hdl.handle.net/10044/1/77665
VL  - 27
ER  -
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