Dr Yuval Elani in an EPSRC Research Fellow working in the Department of Chemistry. His research centres on the development of microfluidic technologies for synthetic biology, specifically for the bottom up construction of artificial cells that resemble biological cells in form and function.
He is currently investigating how these artificial cells can be interfaced with living biological systems – organelles, cells, and tissues – to yield hybrid cellular bionic systems that are composed of living and synthetic components. In particular, Yuval’s research focusses on:
- How artificial cells can be used as cell mimics to probe basic biological phenomena (in particular membrane-based processes) in a simplified environment
- How artificial cells can engineered to perform bespoke and biotechnologically useful functions as synthetic soft-matter micromachines in a suite of industrial and clinical applications.
Yuval has published extensively in the areas of synthetic biology, biointerfaces, and soft-matter biotechnology, and his work has been recognised by the UK Parliamentary and Scientific committee who awarded him the Roscoe Medal and Gold Award in 2015, and by the World Economic Forum, who selected him to be part of their Young Scientist Community. He is also the recipient of the Lord Porter Prize for academic excellence, and holds a prestigious EPSRC Fellowship to conduct blue skies research.
Yuval’s academic training was at Cambridge University where he read Natural Sciences as an undergraduate, and at Imperial College London, where he completed a multidisciplinary MRes studying drug/membrane interactions and a PhD on developing microfluidic technologies for the generation of compartmentalised cell-mimetic microreactors. This was followed by a Doctoral Prize Fellowship, completed in 2016.
Yuval is affiliated with the CAPITALS programme, the Membrane Biophysics Platform, and the Institute of Chemical Biology, and is keen to explore collaborations across the physical and biological sciences, as well as with industry.
If you are a talented and dedicated scientist that is interested in joining the group as an MSci, MRes, UROP, or PhD student, please get in touch.
Salehi-Reyhani A, Ces O, Elani Y, 2017, Artificial cell mimics as simplified models for the study of cell biology, Experimental Biology and Medicine, Vol:242, ISSN:1535-3702, Pages:1309-1317
Elani Y, Law R, Ces O, Vesicle-based artificial cells: recent developments and prospects for drug delivery, Therapeutic Delivery, ISSN:2041-6008
et al., 2015, Measurements of the effect of membrane asymmetry on the mechanical properties of lipid bilayers, Chemical Communications, Vol:51, ISSN:1359-7345, Pages:6976-6979
et al., 2013, Engineering multi-compartment vesicle networks, Chemical Science, Vol:4, ISSN:2041-6520, Pages:3332-3338
Elani Y, Law RV, Ces O, 2015, Protein synthesis in artificial cells: using compartmentalisation for spatial organisation in vesicle bioreactors, Physical Chemistry Chemical Physics, Vol:17, ISSN:1463-9076, Pages:15534-15537
et al., 2012, Novel technologies for the formation of 2-D and 3-D droplet interface bilayer networks, Lab on a Chip, Vol:12, ISSN:1473-0197, Pages:3514-3520
Elani Y, Law RV, Ces O, 2014, Vesicle-based artificial cells as chemical microreactors with spatially segregated reaction pathways, Nature Communications, Vol:5, ISSN:2041-1723
et al., 2014, A droplet trapping microfluidic device for the study of mass-transport across droplet interface bilayers, Pages:1620-1622
Elani Y, Law R, Ces O, 2014, Microfluidic generation of networked droplet collections and lipid membrane constructs, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Pages:677-679, ISSN:1556-5904
et al., 2013, Manufacturing vesicles with internal bilayer partitions: a novel unit for synthetic biology, 9th European-Biophysical-Societies-Association Congress, SPRINGER, Pages:S55-S55, ISSN:0175-7571
Elani Y, 2015, Development of Microfluidic Technologies for the Construction of Multi-Compartment Vesicles and their Applications as Artificial Cells