Imperial College London
Alternate

ProfessorZoltanTakats

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Analytical Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 2760z.takats

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Varshavi:2018:10.3389/fmolb.2018.00028,
author = {Varshavi, D and Scott, FH and Varshavi, D and Veeravalli, S and Phillips, IR and Veselkov, K and Strittmatter, N and Takats, Z and Shephard, EA and Everett, JR},
doi = {10.3389/fmolb.2018.00028},
journal = {Frontiers in Molecular Biosciences},
title = {Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice},
url = {http://dx.doi.org/10.3389/fmolb.2018.00028},
volume = {5},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male, wild-type C57BL/6J and Fmo5-/- (FMO5 KO) mice back-crossed onto the C57BL/6J background. The aim of this study was to identify metabolic signatures that are associated with ageing in both these mouse lines and to characterize the age-related differences in the metabolite profiles between the FMO5 KO mice and their wild-type counterparts at equivalent time points. We identified a range of age-related biomarkers in both urine and plasma. Some metabolites, including urinary 6-hydroxy-6-methylheptan-3-one (6H6MH3O), a mouse sex pheromone, showed similar patterns of changes with age, regardless of genetic background. Others, however, were altered only in the FMO5 KO, or only in the wild-type mice, indicating the impact of genetic modifications on mouse ageing. Elevated concentrations of urinary taurine represent a distinctive, ageing-related change observed only in wild-type mice.
AU  - Varshavi,D
AU  - Scott,FH
AU  - Varshavi,D
AU  - Veeravalli,S
AU  - Phillips,IR
AU  - Veselkov,K
AU  - Strittmatter,N
AU  - Takats,Z
AU  - Shephard,EA
AU  - Everett,JR
DO  - 10.3389/fmolb.2018.00028
PY  - 2018///
SN  - 2296-889X
TI  - Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice
T2  - Frontiers in Molecular Biosciences
UR  - http://dx.doi.org/10.3389/fmolb.2018.00028
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29686991
UR  - http://hdl.handle.net/10044/1/62254
VL  - 5
ER  -
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