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  • Journal article
    Lally PJ, Price DL, Pauliah SS, Bainbridge A, Kurien J, Sivasamy N, Cowan FM, Balraj G, Ayer M, Satheesan K, Ceebi S, Wade A, Swamy R, Padinjattel S, Hutchon B, Vijayakumar M, Nair M, Padinharath K, Zhang H, Cady EB, Shankaran S, Thayyil Set al., 2014,

    Neonatal encephalopathic cerebral injury in south india assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome

    , PLOS One, Vol: 9, ISSN: 1932-6203

    Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South India.MethodsWe recruited consecutive term or near term infants with evidence of perinatal asphyxia and a Thompson encephalopathy score ≥6 within 6 h of birth, over 6 months. We performed conventional MR imaging, diffusion tensor MR imaging and thalamic proton MR spectroscopy within 3 weeks of birth. We computed group-wise differences in white matter fractional anisotropy (FA) using tract based spatial statistics. We allocated Sarnat encephalopathy stage aged 3 days, and evaluated neurodevelopmental outcomes aged 3½ years using Bayley III.ResultsOf the 54 neonates recruited, Sarnat staging was mild in 30 (56%); moderate in 15 (28%) and severe in 6 (11%), with no encephalopathy in 3 (6%). Six infants died. Of the 48 survivors, 44 had images available for analysis. In these infants, imaging indicated perinatal rather than established antenatal origins to injury. Abnormalities were frequently observed in white matter (n = 40, 91%) and cortex (n = 31, 70%) while only 12 (27%) had abnormal basal ganglia/thalami. Reduced white matter FA was associated with Sarnat stage, deep grey nuclear injury, and MR spectroscopy N-acetylaspartate/choline, but not early Thompson scores. Outcome data were obtained in 44 infants (81%) with 38 (79%) survivors examined aged 3½ years; of these, 16 (42%) had adverse neurodevelopmental outcomes.ConclusionsNo infants had evidence for established brain lesions, suggesting potentially treatable perinatal origins. White matter injury was more common than deep brain nuclei injury. Our results support the need for rigorous evaluation of the efficacy of rescue

  • Journal article
    Robertson NJ, Thayyil S, Cady EB, Raivich Get al., 2014,

    Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.

    , Curr Pediatr Rev, Vol: 10, Pages: 37-47

    Neonatal brain injury remains a devastating condition, with poor outcomes despite the institution of an effective neuroprotective strategy of therapeutic hypothermia. There is an urgent need to develop additional neuroprotective strategies and to tailor our clinical predictive ability for families and their infants. Such goals could be more readily achieved if reliable early clinical indicators or biomarkers existed. This review will explore the relation between magnetic resonance (MR) imaging biomarkers and the degree of brain pathology observed in our translational piglet model of perinatal asphyxia. We also suggest biomarker relevance at a cellular level. The review will describe the development needed to optimize and simplify the use of biomarkers to speed up future trials of neuroprotection.

  • Journal article
    Thayyil S, Sebire NJ, Chitty LS, 2013,

    Erratum: Post-mortem MRI versus conventional autopsy in fetuses and children: A prospective validation study (Lancet (2013) 382 (223-233))

    , The Lancet, Vol: 382, ISSN: 0140-6736
  • Journal article
    Thayyil S, Sebire NJ, Chitty LS, 2013,

    Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study (vol 382, pg 223, 2013)

    , LANCET, Vol: 382, Pages: 1980-1980, ISSN: 0140-6736
  • Journal article
    Thayyil S, Sebire NJ, Chitty LS, 2013,

    Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study (vol 382, pg 223, 2013)

    , LANCET, Vol: 382, Pages: 208-208, ISSN: 0140-6736
  • Journal article
    Thayyil S, Sebire NJ, Chitty LS, 2013,

    Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study (vol 382, pg 223, 2013)

    , LANCET, Vol: 382, Pages: 208-208, ISSN: 0140-6736
  • Journal article
    Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong WK, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, De Vita E, Robertson NJ, Taylor AMet al., 2013,

    Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study

    , LANCET, Vol: 382, Pages: 223-233, ISSN: 0140-6736
  • Journal article
    Arthurs OJ, Thayyil S, Wade A, Chong WK, Sebire NJ, Taylor AMet al., 2013,

    Normal ascent of the conus medullaris: a post-mortem foetal MRI study

    , JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 26, Pages: 697-702, ISSN: 1476-7058
  • Journal article
    Thayyil S, Shankaran S, Wade A, Cowan FM, Ayer M, Satheesan K, Sreejith C, Eyles H, Taylor AM, Bainbridge A, Cady EB, Robertson NJ, Price D, Balraj Get al., 2013,

    Whole-body cooling in neonatal encephalopathy using phase changing material

    , ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 98, Pages: F280-F281, ISSN: 1359-2998
  • Journal article
    Ben-Sasi K, Chitty LS, Franck LS, Thayyil S, Judge-Kronis L, Taylor AM, Sebire NJet al., 2013,

    Acceptability of a minimally invasive perinatal/paediatric autopsy: healthcare professionals' views and implications for practice

    , PRENATAL DIAGNOSIS, Vol: 33, Pages: 307-312, ISSN: 0197-3851

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